Hydroxypropyl cellulose, mushonga wemishonga, yakakamurwa kuita yakaderera-inotsiva hydroxypropyl cellulose (L-HPC) uye yakakwirira-inotsiva hydroxypropyl cellulose (H-HPC) zvinoenderana nezvirimo mune inotsiva hydroxypropoxy. L-HPC inoputika kuita colloidal solution mumvura, ine zvinhu zvekunamatira, kuumbwa kwemafirimu, emulsification, nezvimwewo, uye inonyanya kushandiswa sechinhu chinoparadza uye binder; nepo H-HPC ichinyungudika mumvura uye zvakasiyana siyana organic zvinonyungudutsa pakamuri tembiricha, uye ine yakanaka thermoplasticity. , kubatana uye firimu-kugadzira zvinhu, iyo yakaumbwa firimu yakaoma, inopenya, uye yakazara elastic, uye inonyanya kushandiswa semafirimu ekugadzira zvinhu uye kuvhara zvinhu. Iko kushandiswa kweiyo hydroxypropyl cellulose mukugadzirira kwakasimba iko zvino kwakatangwa.
1. Sechipopori chekugadzirira kwakasimba semapiritsi
Nzvimbo yepasi-yakatsiviwahydroxypropyl cellulosecrystalline particles haina kuenzana, ine zviri pachena mamiriro edombo-sechimiro. Ichi chakakasharara chimiro chepamusoro hachiite chete kuti ive nenzvimbo yakakura yepasi, asi zvakare kana yakadzvanywa muhwendefa pamwe chete nemishonga uye zvimwe zvinobatsira, akawanda ma pores uye capillaries anoumbwa muiyo piritsi core, kuitira kuti piritsi core riwedzere hunyoro. chiyero chekunyura uye Kunyura kweMvura kunowedzera kuzvimba. Kushandisa L-HPC sechinhu chinobatsira kunogona kuita kuti piritsi racho rikurumidze kuparara kuva yunifomu yehupfu, uye inovandudza zvakanyanya kuparara, kupera uye bioavailability yehwendefa. Semuenzaniso, kushandiswa kweL-HPC kunogona kukurumidzira kuparara kwemapiritsi eparacetamol, mapiritsi e-aspirin, uye mapiritsi e-chlorpheniramine, uye kuvandudza kuparara kwehuwandu. Kuparadzana uye kunyungudutswa kwemishonga isinganyungudika isina kunyungudika yakadai semapiritsi eofloxacin ane L-HPC seanoparadza aive nani pane ayo ane PVPP yakabatana, CMC-Na uye CMS-Na seanoparadza. Kushandisa L-HPC sechinhu chemukati chinoparadzanisa magranules mu capsules inobatsira kuparara kwegranules, inowedzera nzvimbo yekubatana pakati pemishonga uye kuputika kwepakati, inokurudzira kupera kwemishonga, uye inovandudza bioavailability. Kurumidza-kuburitswa kwakasimba gadziriro dzinomiririrwa nekukasira-kuparara kwegadziriro dzakasimba uye nekukasira-kunyunguduka kwakasimba gadziriro dzine kukurumidza-kuparara, nekukasira-kunyungudika, kukurumidza-kuita mhedzisiro, yakakwirira bioavailability, kuderedzwa kwezvinodhaka kutsamwa kune esophagus uye gastrointestinal turakiti, uye zviri nyore kutora. uye uve nekuteerera kwakanaka. uye zvimwe zvakanakira, kutora chinzvimbo chakakosha mumunda wemishonga. L-HPC yakave imwe yezvinonyanya kukosha zvekugadzirira-kusunungurwa kwakasimba gadziriro nekuda kwesimba rayo hydrophilicity, hygroscopicity, expansibility, pfupi hysteresis nguva yekusvetwa kwemvura, kukurumidza kunyura kwemvura, uye kukurumidza kunyura kwemvura. Iyo yakanaka disintegrant kune nemuromo disintegrated mapiritsi. Paracetamol nemuromo disintegrating mapiritsi akagadzirirwa neL-HPC seanoparadzana, uye mahwendefa akaparara nokukurumidza mukati me20s. L-HPC inoshandiswa se disintegrant yemapiritsi, uye muyero wayo mukuru ndeye 2% kusvika 10%, kazhinji 5%.
2. Sebhainda rekugadzirira zvakadai semapiritsi uye granules
Iyo yakakasharara chimiro cheL-HPC zvakare inoita kuti ive yakakura mosaic mhedzisiro nemishonga uye zvimedu, izvo zvinowedzera dhigirii rekubatana, uye ine yakanaka yekumanikidza kuumba kuita. Mushure mekudzvinyirirwa mumapiritsi, inoratidza kuoma kwakawanda uye kupenya, nokudaro kuvandudza Hunhu hwekuonekwa kwehwendefa. Kunyanya kumapiritsi ayo asiri nyore kuumba, akasununguka kana nyore kufukunura, kuwedzera L-HPC kunogona kuvandudza maitiro. Iyo ciprofloxacin hydrochloride piritsi ine kusasimba kwakashata, nyore kupatsanura uye kunamira, uye iri nyore kuumba mushure mekuwedzera L-HPC, nekuoma kwakakodzera, kutaridzika kwakanaka, uye chiyero chekunyungudika chinosangana nemhando yezvinodiwa. Mushure mekuwedzera L-HPC mupiritsi rinoparara, chitarisiko chayo, friability, kupararira kufanana uye zvimwe zvinhu zvinogadziridzwa zvakanyanya uye zvinovandudzwa. Mushure mokunge starch muzvinyorwa zvepakutanga zvakatsiviwa neL-HPC, kuoma kwehwendefa yeazithromycin inopararira yakawedzerwa, friability yakagadziridzwa, uye matambudziko ekushayikwa kwemakona nemapendero akaora epiritsi yepakutanga akagadziriswa. L-HPC inoshandiswa sebhainda remapiritsi, uye chiyero che5% kusvika 20%; nepo H-HPC ichishandiswa sebhainda remapiritsi, magranules, nezvimwewo, uye muyero mukuru i1% kusvika 5% yegadziriro.
3. Kushandiswa mukuputira firimu uye kutsigirwa uye kudzorwa kusunungurwa gadziriro
Parizvino, zvinhu zvinonyunguduka nemvura zvinowanzoshandiswa mukuputira firimu zvinosanganisira hydroxypropylmethylcellulose (HPMC), hydroxypropylcellulose, polyethylene glycol (PEG) nezvimwe zvakadaro. Hydroxypropyl cellulose inowanzoshandiswa semugadziri wekugadzira firimu mune firimu coating premixing zvinhu nekuda kweiyo yakaoma, elastic uye inopenya firimu. Kana hydroxypropyl cellulose yakasanganiswa nemamwe tembiricha-inodzivirira coating agents, kuita kwekupfeka kwayo kunogona kuvandudzwa.
Kushandisa maexcipient akakodzera uye matekiniki ekuita kuti mushonga uve matrix mahwendefa, gastric inoyangarara mahwendefa, akawanda-layer mahwendefa, akavharidzirwa mahwendefa, osmotic pombi mapiritsi uye mamwe anononoka uye anodzorwa mahwendefa ekuburitsa, kukosha kuri mu: kuwedzera dhigirii rekutora zvinodhaka uye kudzikama. mushonga uri muropa. Kuisa pfungwa, kuderedza kuita kwakashata, kuderedza kuwanda kwemishonga, uye kuedza kukwidziridza kurapa nedosi diki, uye kuderedza maitiro asina kunaka. Hydroxypropyl cellulose ndechimwe chezvinhu zvakakosha zvekugadzirira kwakadaro. Kuparara uye kusunungurwa kwe diclofenac sodium mapiritsi kunodzorwa nekushandisa hydroxypropyl cellulose uye ethyl cellulose sechinhu chakabatana uye skeleton. Mushure mekutonga nemuromo uye kusangana negastric muto, pamusoro pe diclofenac sodium inosimudzira-kuburitsa mahwendefa anozoiswa hydrate mu gel. Kuburikidza nekuparara kwegel uye kuparadzirwa kwemamorekuru ezvinodhaka mugeji rejelisi, chinangwa chekunonoka kuburitswa kwemamorekuru emishonga chinowanikwa. Hydroxypropyl cellulose inoshandiswa seThe controlled-release matrix yepiritsi, kana zviri mukati me blocker ethyl cellulose zvinogara, zvirimo muhwendefa zvinotarisa zvakananga kuburitswa kwemushonga, uye mushonga kubva pahwendefa ine yakakwirira yemukati. yehydroxypropyl cellulose Kuburitswa kunononoka. Mapeti akavharidzirwa akagadzirwa nekushandisa L-HPC uye chimwe chikamu cheHPMC sechigadziro chekuputira chekuputira sechidzitiro chekuzvimba, uye seyakadzora-kuburitsa layer yekuputira ne ethyl cellulose aqueous dispersion. Kana iyo yekuzvimba layer yekuraira uye dosi yakagadziriswa, nekudzora ukobvu hweiyo inodzorwa yekuburitsa layer, iyo yakavharwa pellets inogona kuburitswa panguva dzakasiyana dzinotarisirwa. Mhando dzinoverengeka dzemapellets akavharidzirwa ane huremu hwakasiyana hweiyo inodzorwa yekuburitsa layer inosanganiswa kugadzira Shuxiong inosimudzira-kuburitsa capsules. Munzvimbo yekunyungudutsa, akasiyana-siyana akaputirwa pellets anogona kuburitsa zvinodhaka zvakateerana panguva dzakasiyana, kuitira kuti zvikamu zvine akasiyana emuviri nemakemikari zvimiro Kuburitswa panguva imwe chete kunowanikwa panguva imwechete sekusunungurwa kwakasimba.
Nguva yekutumira: Zvita-28-2022