1. Nhanganyaya kuHPMC
Hydroxypropyl Methylcellulose (HPMC) isiri-ionic cellulose ether inoshandiswa zvakanyanya mukuvaka zvinhu, machira, mishonga, zvizorwa, chikafu uye mamwe minda. Nekuda kwekunyungudika kwayo kwemvura, gelling uye kukora zvivakwa, HPMC inowanzoshandiswa seyakakora, stabilizer uye gelling agent. Kunyungudika kwemvura kweHPMC ndeimwe yeayo akakosha zvivakwa mumashandisirwo anoshanda, asi nguva yekunyungudika kwayo inosiyana nekuda kwezvinhu zvakawanda.
2. Dissolution process yeHPMC
HPMC ine mvura yakanaka solubility, asi panguva yekunyungudika, inoda kutora mvura uye kuzvimba kutanga, uye zvishoma nezvishoma inonyungudika. Iyi nzira inowanzogoverwa mumatanho anotevera:
Kutorwa kwemvura nekuzvimba: HPMC inotanga kutora mvura mumvura, uye mamorekuru ecellulose anotanga kuzvimba.
Dispersion mixing: HPMC yakaparadzirwa zvakaenzana mumvura nekukuchidzira kana dzimwe nzira dzemuchina kudzivirira kusangana.
Dissolution kugadzira mhinduro: Pasi pemamiriro akakodzera, HPMC mamorekuru anonyururwa zvishoma nezvishoma uye kunyungudika mumvura kuti agadzire yakagadzikana colloidal mhinduro.
3. Kuparara nguva yeHPMC
Iyo nguva yekuparara kweHPMC haina kugadzikiswa, kazhinji kubva pamaminitsi gumi nemashanu kusvika kumaawa akati wandei, uye nguva yakatarwa zvinoenderana nezvinotevera zvinhu:
Type uye viscosity giredhi yeHPMC: Iyo molecular uremu uye viscosity giredhi yeHPMC ine yakakosha mhedzisiro panguva yekuparara. HPMC ine high viscosity inotora nguva yakareba kuti iparadze, nepo HPMC ine yakaderera viscosity inonyungudika nekukurumidza. Semuenzaniso, 4000 cps HPMC inogona kutora nguva yakareba kuti inyunguduke, nepo 50 cps HPMC inogona kunyungudika zvachose mukati memaminitsi gumi nemashanu.
Tembiricha yemvura: Tembiricha chinhu chakakosha chinokanganisa nguva yekuparara kweHPMC. Kazhinji kutaura, HPMC inotora mvura nekuzvimba nekukurumidza mumvura inotonhora, asi inonyungudika zvishoma nezvishoma; mumvura inopisa (sepamusoro pe60°C), HPMC ichaita yenguva isinganyungudika nyika. Naizvozvo, iyo "mvura inotonhora uye inopisa kaviri kunyungudika nzira" yekutanga kupararira nemvura inotonhora uyezve kupisa kumusoro kunowanzo shandiswa kukurumidza kuparara.
Dissolution nzira: Iyo nzira yekumisa zvakare ine simba guru panguva yekuparara kweHPMC. Nzira dzakajairwa dzekunyungudutsa dzinosanganisira mechanical inosimudzira, ultrasonic kurapwa kana kushandiswa kwepamusoro-kushevedzera michina. Mechanical inobvongodza inogona kunyatso wedzera chiyero chekunyungudika, asi kana ikasashandiswa nemazvo, inogona kugadzira mapundu uye kukanganisa kushanda kwekupera. Kushandisa high-speed stirrer kana homogenizer kunogona kupfupisa zvakanyanya nguva yekuparara.
HPMC particle size: Iwo madiki madiki, anokurumidza kukurumidza kunyungudika. Fine-particle HPMC iri nyore kuparadzira uye kunyungudika zvakaenzana, uye inowanzo shandiswa mumamiriro ekushandisa ane yakakwira dissolution rate zvinodiwa.
Solvent medium: Kunyangwe HPMC ichinyanya kunyungudika mumvura, inogona zvakare kunyungudika mune zvimwe organic zvinonyungudutsa, senge ethanol uye propylene glycol aqueous mhinduro. Different solvent systems inokanganisa chiyero chekuparara. Kune organic solvents, nguva yekunyungudika inowanzoreba kupfuura iri mumvura.
4. Matambudziko akajairika mukuparara kweHPMC
Agglomeration phenomenon: HPMC inowanzoita mapundu kana yanyungudutswa mumvura, kunyanya kana tembiricha yemvura yakakwira kana kubvongodza kusina kukwana. Izvi zvinodaro nekuti pamusoro peHPMC inotora mvura uye inowedzera nekukurumidza, uye mukati haisati yasangana nemvura, zvichikonzera kunonoka kunyungudika kwezvinhu zvemukati. Naizvozvo, mukushanda chaiko, inowanzoshandiswa zvishoma nezvishoma uye zvakaenzanirana kumwaya HPMC mumvura inotonhora kutanga, uye kuizunza zvakakodzera kudzivirira kusangana.
Kuparara kusina kukwana: Dzimwe nguva mhinduro yeHPMC inotaridzika yakafanana, asi chaizvoizvo chikamu che cellulose hachina kunyungudika zvachose. Panguva ino, zvakakosha kuwedzera nguva yekukurudzira, kana kukurudzira kuparara kuburikidza nekutonga kwakakodzera kwekushisa uye nzira dzemagetsi.
5. Nzira yekugadzirisa sei nguva yekuparara kweHPMC
Shandisa nzira yekuparadzira mvura inotonhora: dzvanya zvishoma nezvishoma HPMC mumvura inotonhora kudzivirira kuungana kunokonzerwa nekutorwa kwemvura nekukurumidza uye kuwedzera. Mushure mokunge HPMC yapararira zvachose, kupisa kusvika 40-60°C kukurudzira kuparara kwakazara kweHPMC.
Sarudzo yemidziyo inosimudzira: Kune zviratidziro zvine yakakwira dissolution kumhanya zvinodikanwa, unogona kusarudza kushandisa yakakwirira-yekusheya musanganiswa, homogenizers uye mimwe michina kuwedzera chiyero chekukurudzira uye kushanda nesimba uye kupfupisa nguva yekunyungudika.
Kudzora tembiricha: Tembiricha kutonga ndiyo kiyi yekupedza HPMC. Dzivisa kushandisa mvura inopisa ine tembiricha yakanyanya kunyungudutsa HPMC zvakananga, asi shandisa mvura inotonhora yekuparadzira uye wozodziya. Kune akasiyana masisitimu ekushandisa, unogona kusarudza yakakodzera kupisa tembiricha zvinoenderana nezvaunoda.
Iyo nguva yekuparara kweHPMC inzira ine simba inobatwa nezvinhu zvakawanda. Kazhinji kutaura, nguva yekuparara kwemaminetsi gumi nemashanu kusvika kumaawa akati wandei yakajairika, asi nguva yekunyungudika inogona kupfupikiswa zvakanyanya nekugadzirisa nzira yekunyungudutsa, kukurumidza kukurumidza, saizi yechikamu uye tembiricha kutonga.
Nguva yekutumira: Oct-25-2024