Mea'ai Fa'afoma'i Fa'apitoa Cellulose Eter

O le cellulose ether masani o se faaupuga lautele mo se faasologa omea e maua mai i le cellulosegaosia e ala ile tali ole alkali cellulose ma etherifying agent i lalo o nisi tulaga. O se oloa lea o vaega o le hydroxyl i luga o cellulose macromolecules o loʻo suia atoa pe suia atoa e vaega ether. Cellulose ethers e faʻaaogaina lautele i fanua o suauʻu, mea faufale, paʻu, meaʻai, vailaʻau, ma vailaʻau i aso uma. I matā'upu 'ese'ese, o mea tau vaila'au o lo'o i totonu o le ogatotonu ma le maualuga pito i luga ole alamanuia, fa'atasi ai ma le maualuga o le tau fa'aopoopo. Ona o manaoga faʻapitoa, o le gaosiga o vailaʻau-grade cellulose ether e faigata foi. E mafai ona fa'apea o le tulaga lelei o vaila'au-va'aiga oloa e mafai ona fa'atusalia le malosi fa'apitoa o le cellulose ether pisinisi. E masani ona faʻaopoopoina le cellulose ether e fai ma poloka, mea matrix ma mafiafia e fai ai matrix matrix matrix, mea faʻapipiʻi gatric-soluble, mea faʻapipiʻi microcapsule tuʻuina atu, mea faʻapipiʻi faʻamaʻi faʻamaʻi, ma isi.

Sodium carboxymethyl cellulose:

Carboxymethyl cellulose sodium (CMC-Na) o le cellulose ether ituaiga ma le tele o gaosiga ma taumafa i le fale ma fafo. O se ionic cellulose ether e faia mai le cotton ma fafie e ala i le alkalization ma le etherification i le chloroacetic acid. CMC-Na ose vaila'au fa'aaoga masani. E masani ona faʻaaogaina e avea o se mea e faʻapipiʻi mo sauniuniga faʻamalosi, o se mea faʻafefeteina, o se mea faʻapipiʻi, ma se mea faʻapipiʻi mo sauniuniga vai. E mafai foi ona faʻaaogaina e avea o se matrix soluble vai ma mea e fai ata tifaga. E masani ona fa'aogaina e fai ma mea e fa'asa'o fa'ama'i fa'ama'i ma vaila'au fa'ama'i fa'amatu'u fa'asa'o i sauniuniga fa'asa'o (pulea).

I le faaopoopo atu i le sodium carboxymethylcellulose e avea o se vailaʻau faʻapitoa, e mafai foi ona faʻaaogaina le sodium croscarmellose e avea o se vailaʻau faʻapitoa. Croscarmellose sodium (CCMC-Na) o se mea e le mafai ona faʻaaogaina i le vai o le carboxymethylcellulose e tali atu ma se sui faʻafesoʻotaʻi i se vevela faapitoa (40-80 ° C) i lalo o le gaioiga a se faʻamaʻi faʻamaʻi ma faʻamamaina. I le avea ai ma sui faʻafesoʻotaʻi, propylene glycol, succinic anhydride, maleic anhydride ma adipic anhydride e mafai ona faʻaaogaina. Croscarmellose sodium o loʻo faʻaaogaina e avea o se faʻamaʻi mo papa, capsules ma granules i sauniuniga tautala. E fa'alagolago i a'afiaga capillary ma fula e malepe ai. E i ai le compressibility lelei ma le malosi disintegration malosi. O suʻesuʻega ua faʻaalia ai o le fulafula o le sodium croscarmellose i totonu o le vai e sili atu nai lo mea faʻamaʻi masani e pei o le sodium carmellose low-substituted ma hydrated microcrystalline cellulose.

Methylcellulose:

Methyl cellulose (MC) o se mea e le ionic cellulose eter e tasi e faia mai le cotton ma laupapa e ala i alkalization ma methyl chloride etherification. Methylcellulose e sili ona lelei le solubility vai ma e mautu i le va o le pH2.0 ~ 13.0. E masani ona faʻaaogaina i vailaʻau faʻapitoa, ma e faʻaaogaina i sublingual tablets, intramuscular injections, ophthalmic preparations, oral capsules, oral suspensions, oral tablets and topical preparations. E le gata i lea, i sauniuniga faʻasaʻo faʻamalolo, e mafai ona faʻaaogaina le MC e pei o le hydrophilic gel matrix sustained-release sauniuniga, gastric-soluble mea faʻapipiʻi, faʻapipiʻi faʻamalolo microcapsule mea faʻapipiʻi, faʻamalologa-faʻamalolo mea ata tifaga, ma isi.

Hydroxypropyl methyl cellulose:

Hydroxypropyl methylcellulose (HPMC) o se non-ionic cellulose fefiloi eter faia mai le cotton ma laupapa e ala i alkalization, propylene oxide ma methyl chloride etherification. E leai se manogi, leai se tofo, e le o'ona, solu ile vai malulu ma fa'alili ile vai vevela. Hydroxypropyl methylcellulose o se cellulose fefiloi ether ituaiga o lona gaosiga, fua ma le lelei ua vave ona faateleina i Saina i le 15 tausaga talu ai. O se tasi foi o vailaʻau faʻapitoa e sili ona faʻaaogaina i le fale ma fafo. tausaga o talafaasolopito. I le taimi nei, o le faʻaogaina o le HPMC o loʻo faʻaalia i vaega nei e lima:

O le tasi e pei o se fusifusia ma fa'amavae. I le avea ai o se mea fa'apipi'i, e mafai e le HPMC ona fa'afaigofie ona susu le vaila'au, ma e mafai ona fa'alautele fa'aselau taimi pe a uma ona mitiia le vai, ina ia mafai ai ona fa'aleleia atili le fua fa'amavae po'o le fa'asa'olotoina o le laulau. O le HPMC e malosi le viscosity, lea e mafai ona faʻaleleia ai le viscosity vaega ma faʻaleleia le faʻapipiʻiina o mea mataʻutia ma le maʻaleʻale poʻo le malepelepe. O le HPMC e maualalo le viscosity e mafai ona fa'aoga e pei o le fusifusia ma le fa'amavae, ma oi latou e maualuga le viscosity e mafai ona fa'aaogaina e fai ma fusi.

O le lona lua o se mea e fa'asa'olotoina ma fa'atonutonu mo sauniuniga tu'u. O le HPMC ose mea e masani ona fa'aogaina hydrogel matrix i sauniuniga fa'asa'oloto. E mafai ona fa'aogaina le HPMC e fai ma fusifusia, viscosifier ma le fa'amautu le sui, ma le maualuga-viscosity grade (4000-100000mPa·s) e mafai ona fa'aogaina le HPMC e saunia ai mea fa'afefiloi Blocking agent mo capsules, hydrogel matrix. papa'a fa'alaua'itele. E mafai ona solu le HPMC i le vai gastrointestinal, o loʻo i ai le lelei o le faʻapipiʻiina lelei, lelei le suavai, malosi le utaina o vailaʻau, ma uiga faʻamalolo e le afaina i le PH. O se mea e sili ona taua e ave ai le hydrophilic i faiga sauniuni fa'asa'o ma e masani ona fa'aaogaina e pei o le Hydrophilic gel matrix ma mea fa'apipi'i mo sauniuniga fa'asa'oloto, fa'apea fo'i ma mea fa'aopoopo mo tapenaga fa'a'a'a'e ma tapenaga ata tifaga vaila'au fa'asao.

O le lona tolu e avea o se mea e ufiufi ai ata tifaga. O le HPMC o lo'o iai mea lelei e fai ai ata. O le ata na faia e ia e toniga, manino ma faigata, ma e le faigofie ona pipii i le taimi o le gaosiga. Aemaise lava mo vailaʻau e faigofie ona faʻafefe le susu ma e le mautu, faʻaaogaina e avea o se vaega tuʻufua e mafai ona faʻaleleia atili ai le mautu o le vailaʻau ma puipuia O le ata e suia le lanu. O le HPMC e iai le tele o fa'amatalaga viscosity. Afai e filifilia lelei, o le lelei ma foliga vaaia o laupepa ufiufi e sili atu nai lo isi mea. Ole fa'atonuga masani ole 2% ile 10%.

O lona fa e pei o se mea capsule. I tausaga talu ai nei, faʻatasi ai ma faʻalavelave faʻafuaseʻi o faʻamaʻi manu i le lalolagi, pe a faʻatusatusa i capsules gelatin, o fualaau faisua ua avea ma pele fou o falemaʻi ma meaʻai. Pfizer o le Iunaite Setete ua fa'amanuiaina le HPMC mai la'au fa'anatura ma saunia VcapTM fualaau faisua capsules. Pe a faatusatusa i capsules gaogao gelatin masani, capsules laau ei ai le lelei o le fetuutuunai lautele, leai se tulaga lamatia o felafolafoaiga tali ma maualuga mautu. Ole fua ole fa'amalolo ole vaila'au e fai si mautu, ma e la'ititi le eseesega o tagata ta'ito'atasi. A maeʻa le faʻamavaeina i totonu o le tino o le tagata, e le faʻafefe ma mafai ona faʻaumatia O le mea e alu ese mai le tino. I tulaga o le teuina, pe a maeʻa le tele o suʻega, e toetoe lava a le faʻavaivai i lalo o tulaga maualalo maualalo, ma o meatotino o le atigi pusa o loʻo tumau pea i lalo o tulaga maualuga maualuga, ma o faʻailoga o pusa laau e le afaina i lalo o le teuina tele. tulaga. Faatasi ai ma le malamalama o tagata i pusa laau ma le suiga o mataupu tau vailaau lautele i totonu ma fafo, o le manaoga maketi mo capsules laau o le a vave ona tupu.

O le lona lima e avea o se sooupu le tumau. O le tapenaga o le vai fa'agata fa'agata o se fa'aoga masani fa'asoifua maloloina, ose faiga ta'ape eseese lea e fa'asalalauina ai vaila'au mafiafia e le mafai ona fa'afefeteina i totonu o se ala fa'asalalau vai. O le mautu o le faiga e fuafua ai le tulaga lelei o le sauniuniga o le suavai faʻamalolo. HPMC colloidal solution e mafai ona faʻaitiitia ai le faʻalavelave faʻafefe-suavai, faʻaitiitia le malosi saoloto o luga ole vaega malo, ma faʻamautu le faiga faʻasalalau heterogeneous. Ose so'o fa'amalolo lelei. O le HPMC o loʻo faʻaaogaina e avea o se mafiafia mo mataʻu mata, faʻatasi ai ma le anotusi o le 0.45% i le 1.0%.

Hydroxypropyl Cellulose:

O le Hydroxypropyl cellulose (HPC) o se ether e le'o ionic cellulose e faia mai le cotton ma fafie e ala i le alkalization ma le propylene oxide etherification. E masani ona solu le HPC i le vai i lalo ole 40 ° C ma se numera tele o polar solvents, ma o lona faʻatinoga e fesoʻotaʻi ma le anotusi o le hydroxypropyl group ma le tikeri o le polymerization. E mafai ona fetaui le HPC ma vailaʻau eseese ma e lelei le inertia.

O le hydroxypropyl cellulose (L-HPC) e faʻaaogaina e faʻaaogaina e pei o le faʻamavaeina ma le fusifusia. -HPC e mafai ona faʻaleleia le maaa ma le susulu o le laulau, ma e mafai foi ona faʻaumatia vave le laulau, faʻaleleia le lelei o totonu o le laulau, ma faʻaleleia le togafitiga.

Ole hydroxypropyl cellulose (H-HPC) sili ona suitulaga e mafai ona faʻaaogaina e fai ma fusi mo papa, granules, ma granules lelei i totonu o vailaʻau. O le H-HPC o loʻo iai ni mea e sili ona lelei e fai ai ata, ma o le ata na maua e faigata ma faʻamalosi, lea e mafai ona faʻatusatusa i plasticizers. O le faʻatinoga o le ata e mafai ona faʻaleleia atili e ala i le faʻafefiloi ma isi mea faʻapipiʻi faʻapipiʻi susu, ma e masani ona faʻaaogaina e fai ma mea faʻapipiʻi ata mo papa. E mafai fo'i ona fa'aogaina le H-HPC e fai ma mea fa'ata'oto e saunia ai matrix sustained-release tablets, sustained-release pellets ma fa'alua fa'apalapala fa'amau-fa'asa'o.

Hydroxyethyl cellulose

O le Hydroxyethyl cellulose (HEC) o se ether e le o ni ionic cellulose e faia mai le cotton ma fafie e ala i le alkalization ma le etherification o le ethylene oxide. I le fanua o vailaʻau, HEC e masani ona faʻaaogaina e avea o se mafiafia, colloidal protective agent, faʻapipiʻi, dispersant, stabilizer, suspending agent, film-forming agent and supported-release material, ma e mafai ona faʻaaogaina i luga ole emulsions, suauʻu, mata matau, Suavai tu'ugutu, papama'a malo, capsule ma isi fomu fua. Hydroxyethyl cellulose ua fa'amauina i le US Pharmacopoeia/US National Formulary ma le European Pharmacopoeia.

Ethyl cellulose:

O le Ethyl cellulose (EC) o se tasi o mea e sili ona fa'aaogaina i le vai e le mafai ona fa'afefeteina. O le EC e le oona, mautu, e le mafai ona solu i le vai, vai po'o se vaifofo alkali, ma solu i solu fa'aola pei ole ethanol ma methanol. Ole solvent masani ole toluene/ethanol e pei ole 4/1 (mamafa) ole solvent fefiloi. E tele faʻaoga a le EC i vailaʻau faʻasaʻo faʻamalolo, faʻaaogaina lautele e avea ma avefeʻau, microcapsules, ma faʻapipiʻiina mea faʻapipiʻi ata mo sauniuniga faʻasaʻo faʻamalosi, e pei o poloka poloka, faʻapipiʻi, ma mea faʻapipiʻi ata, faʻaaogaina e fai ma ata tifaga e saunia ai. ituaiga eseese o matrix sustained-release tablets, faʻaaogaina e fai ma mea faʻafefiloi e saunia ai sauniuniga faʻapipiʻi faʻapipiʻiina, pellets faʻapipiʻiina, ma faʻaaogaina e fai ma mea faʻapipiʻi fesoasoani e saunia ai microcapsules faʻamalolo; e mafai foi ona faʻaaogaina lautele e avea o se mea e feaveaʻi Mo le sauniuniga o faʻasalalauga malosi; fa'aaogaina lautele i tekinolosi fa'afoma'i e pei o se mea e fai ai ata tifaga ma le ufiufi puipui, fa'apea fo'i ma fa'amau ma fa'atumu. I le avea ai ma ufiufi puipui o le laulau, e mafai ona faʻaitiitia le lagona o le laulau i le susu ma puipuia ai le vailaʻau mai le aʻafia i le susu, faʻaleagaina ma faʻaleagaina; e mafai fo'i ona fa'atupuina se fa'agasolo fa'asa'o fa'agesegese o le gel, microencapsulate le polymer, ma mafai ai ona fa'asa'olotoina le a'afiaga o vaila'au.