Hydroxypropyl methylcellulose HPMC o se ituaiga e le-ionic cellulose fefiloi eter. E ese mai le ionic methyl carboxymethyl cellulose mixed ether, e le tali atu i metala mamafa. Ona o le eseesega o fua faatatau o le methoxyl anotusi ma le hydroxypropyl anotusi i le hydroxypropyl methylcellulose ma viscosities eseese, e tele ituaiga ma meatotino eseese, mo se faataitaiga, maualuga methoxyl anotusi ma maualalo hydroxypropyl anotusi O lona faatinoga e latalata i le methyl cellulose, ae o le faatinoga o mea maualalo methoxy ma maualuga hydroxypropyl anotusi e latalata i le hydroxypropyl methyl cellulose. Ae ui i lea, i ituaiga taʻitasi, e ui lava naʻo se vaega itiiti o le hydroxypropyl group poʻo se vaega itiiti o le methoxyl group o loʻo i ai, o le solubility i solvents organic poʻo le vevela o le flocculation i le vai vaifofo e matua ese lava.
1. Le solubility o le hydroxypropyl methylcellulose
①Solubility o le hydroxypropyl methylcellulose i totonu o le vai Hydroxypropyl methylcellulose o le mea moni lava o se ituaiga o methylcellulose suia e propylene oxide (methoxypropylene), o lea o loʻo i ai pea mea tutusa e pei o le methyl cellulose O le cellulose e iai uiga tutusa o le vai malulu ma le vai vevela. Ae ui i lea, ona o le suiga o le hydroxypropyl vaega, o lona vevela gelation i le vai vevela e sili atu le maualuga nai lo le methyl cellulose. Mo se faʻataʻitaʻiga, o le viscosity o le hydroxypropyl methylcellulose solution vai ma le 2% methoxy content substitution degree DS=0.73 ma le hydroxypropyl content MS=0.46 o se oloa o le 500 mpa?s i le 20 ° C, ma lona vevela gel E mafai ona latalata ile 100° C, a'o le methyl cellulose i le vevela tutusa e na'o le 55°C. Ae o lona faʻamavaeina i le vai, ua matua faʻaleleia atili. Mo se faʻataʻitaʻiga, o le pulverized hydroxypropyl methylcellulose (o se oloa e iai le tele o le 0.2 ~ 0.5mm ma le 4% vaifofo viscosity o 2pa?s i le 20 ° C e mafai ona faʻatau i I le vevela o le potu, e faigofie ona solu i le vai e aunoa ma le malulu. .
②Solubility o le hydroxypropyl methylcellulose i solu faʻalaʻau O le solubility o le hydroxypropyl methylcellulose i solu faʻaola e sili atu foi nai lo le methylcellulose. Mo oloa i luga ole 2.1,maualuga-viscosity hydroxypropyl methylcelluloseo loʻo i ai le hydroxypropyl MS = 1.5 ~ 1.8 ma le methoxy DS = 0.2 ~ 1.0, faʻatasi ai ma se tikeri atoa o le sui i luga aʻe o le 1.8, e mafai ona soluble i anhydrous methanol ma ethanol solutions Medium, ma thermoplastic ma vai-soluble. E mafai foi ona solu i totonu o le chlorinated hydrocarbons e pei ole methylene chloride ma le chloroform, ma solvents organic pei ole acetone, isopropanol ma le diacetone alcohol. O lona solubility i soluble organic e sili atu nai lo le solubility i le vai.
2. O mea e aafia ai le viscosity o le hydroxypropyl methylcellulose
Mea e A'afia ai le Viscosity o le Hydroxypropyl Methyl Cellulose O le fa'ai'uga masani ole viscosity o le hydroxypropyl methyl cellulose e tutusa ma isi cellulose ethers. E fuaina i le 20°C ma le 2% vaifofo vai e fai ma tulaga masani. O le viscosity o le oloa lava e tasi e faateleina i le faateleina o le faʻatonuga. Mo oloa e eseese mole mole mamafa i le faʻatonuga tutusa, o le oloa e tele mole mamafa mamafa e maualuga atu le viscosity. O lona sootaga ma le vevela e tutusa ma le methyl cellulose. A oʻo i luga le vevela, e amata ona faʻaitiitia le viscosity, ae a oʻo i se vevela, faʻafuaseʻi ona oso aʻe le viscosity ma tupu ai le gelation. O le vevela gel o oloa maualalo-viscosity e maualuga atu. e maualuga. O lona tulaga gel e le gata e fesoʻotaʻi ma le viscosity o le ether, ae e fesoʻotaʻi foi ma le fua faatatau o le methoxyl group ma le hydroxypropyl group i le ether ma le tele o le aofaʻi o le tikeri sui. E tatau ona maitauina o le hydroxypropyl methylcellulose o le pseudoplastic foi, ma o lona fofo e mautu i le vevela o le potu e aunoa ma se faʻaleagaina i le viscosity sei vagana ai le avanoa e faʻaleagaina ai le enzymatic.
3. Hydroxypropyl methylcellulose e tetee i le acid ma alkali
Hydroxypropyl methylcellulose acid ma alkali tetee Hydroxypropyl methylcellulose e masani ona mautu i acids ma alkalis, ma e le aafia i le tele o pH 2 ~ 12. E mafai ona tatalia se aofaiga faapitoa o le acid malamalama, E pei o le formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, ma isi. Ae o le acid concentrated ei ai le aafiaga o le faaitiitia o le viscosity. Alkalis pei o le suka, caustic potash ma le lime vai e leai se aoga i ai, ae e mafai ona faʻateleina le viscosity o le vaifofo, ona faʻaitiitia malie ai lea.
4. Le miscibility o le hydroxypropyl methylcellulose
Fa'aliga ole hydroxypropyl methylcellulose Hydroxypropyl methylcellulose solution e mafai ona fa'afefiloi ma vai-soluble polymer compounds ina ia avea ma se vaifofo toniga ma manino ma maualuga le viscosity. O nei polymer compound e aofia ai le polyethylene glycol, polyvinyl acetate, polysilicone, polymethylvinylsiloxane, hydroxyethyl cellulose, ma le methyl cellulose. O mea fa'alenatura maualuga mole mole e pei o le gum arabic, locust bean gum, karaya gum, ma isi mea e lelei foi le fetaui ma lona fofo. Hydroxypropyl methylcellulose e mafai foi ona faʻafefiloi ma le mannitol ester poʻo le sorbitol ester o le stearic acid poʻo le palmitic acid, ma e mafai foi ona faʻafefiloi ma le glycerin, sorbitol ma le mannitol, ma e mafai ona faʻaaogaina nei mea e pei o le hydroxypropyl methylcellulose Plasticizer mo cellulose.
5. Insolubilization ma vai solubility o le hydroxypropyl methylcellulose
O ethers cellulose e le mafai ona solu i le vai o le hydroxypropyl methylcellulose e mafai ona faʻafesoʻotaʻi faʻatasi ma aldehydes i luga o le fogaeleele, ina ia faʻafefeteina nei ethers soluble vai i le vaifofo ma avea ma mea e le mafai ona faʻafefe i le vai. O aldehydes e faʻaaogaina ai le hydroxypropyl methylcellulose e le mafai ona faʻaaogaina e aofia ai formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, ma isi. Pe a faʻaaogaina formaldehyde, e tatau ona gauai faʻapitoa i le tau o le pH o le vaifofo, lea e tali vave ai le glyoxal, o le mea lea e masani ona faʻaogaina ai le glyoxal e pei o se crosslink. sooupu i le gaosiga o alamanuia. O le aofaʻi o lenei ituaiga o fesoʻotaʻiga fesoʻotaʻiga i le fofo o le 0.2% ~ 10% o le tele o le eter, sili 7% ~ 10%, mo se faʻataʻitaʻiga, 3.3% ~ 6% o le glyoxal e sili ona talafeagai. Ole vevela ole togafitiga lautele ole 0 ~ 30℃, ma ole taimi ole 1~120min. E mana'omia ona faia le fa'agasologa o feso'ota'iga i lalo ole tulaga fa'ama'i. E masani lava, o le vaifofo e muamua faʻaopoopoina i le inorganic malosi acid poʻo le organic carboxylic acid e faʻafetaui ai le pH o le vaifofo i le 2 ~ 6, sili i le va o le 4 ~ 6, ona faʻaopopo lea o aldehydes e faʻatino ai le fesoʻotaʻiga fesoʻotaʻiga. O le vailaʻau faʻaaogaina o loʻo i ai le suka hydrochloric, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxyacetic acid, succinic acid poʻo le citric acid ma isi, lea e fautuaina ai le formic acid poʻo le acetic acid, ma le formic acid e sili ona lelei. O le acid ma le aldehyde e mafai foi ona faʻaopoopoina i le taimi e tasi e faʻataga ai le vaifofo e oʻo i se fesoʻotaʻiga fesoʻotaʻiga i totonu o le pH manaʻomia. O lenei tali e masani ona faʻaaogaina i le faʻagasologa o togafitiga mulimuli i le sauniuniga o le cellulose ethers. A maeʻa le cellulose ether e le mafai ona faʻaaogaina, e faigofie ona fufulu ma faʻamamā i le vai ile 20 ~ 25 ° C. A faʻaaogaina le oloa, e mafai ona faʻaopopo mea alkaline i le vaifofo o le oloa e faʻafetaui ai le pH o le vaifofo e avea ma alkaline, ma o le a faʻamavae vave le oloa i le fofo. O lenei metotia e faʻaoga foi i le togafitiga o le ata pe a uma ona faia le cellulose ether solution i totonu o se ata tifaga e avea ai ma ata e le mafai ona faʻaaogaina.
6. Enzyme tetee o hydroxypropyl methylcellulose
O le tetee o le enzyme o le hydroxypropyl methylcellulose o loʻo maua mai i le cellulose, e pei o vaega taʻitasi anhydroglucose, pe afai o loʻo i ai se vaega faʻapipiʻi mautu, e le faigofie ona aʻafia i meaola ninii, ae o le mea moni o le oloa maeʻa Pe a sili atu le tau suitulaga i le 1, e o le a faʻaleagaina foʻi e enzymes, o lona uiga o le tikeri o le sui o vaega taʻitasi i luga o le filifili cellulose e le lava le tutusa, ma e mafai e microorganisms ona faʻaumatia i luga o le vaega anhydroglucose unsubstituted e fai sugars , e avea ma meaʻai mo microorganisms e mitiia. O le mea lea, afai o le tikeri o le etherification suitulaga o le cellulose faateleina, o le a faateleina foi le tetee i le tafia enzymatic o cellulose ether. E tusa ai ma lipoti, i lalo o tulaga pulea, o le hydrolysis taunuuga o enzymes, o le viscosity totoe o le hydroxypropyl methylcellulose (DS = 1.9) o le 13.2%, methylcellulose (DS = 1.83) o le 7.3%, methylcellulose (DS = 1.66) o le 3.8%, ma le hydroxyethyl cellulose e 1.7%. E mafai ona iloa o le hydroxypropyl methylcellulose o loʻo i ai se malosi malosi e tetee atu ai i le enzyme. O le mea lea, o le sili atu o le enzyme teteʻe o le hydroxypropyl methylcellulose, faʻatasi ma lona dispersibility lelei, mafiafia ma ata-fausia meatotino, e faʻaaogaina i vai-emulsion coatings, ma isi, ma e masani lava e le manaʻomia le faʻaopoopoina o mea faʻasao. Ae ui i lea, mo le teuina mo se taimi umi o le fofo poʻo le faʻaleagaina mai fafo, e mafai ona faʻapipiʻi mea faʻasao e fai ma puipuiga, ma e mafai ona fuafua le filifiliga e tusa ai ma manaoga mulimuli o le fofo. Phenylmercuric acetate ma manganese fluorosilicate o ni puipuiga lelei, ae o loʻo i ai uma le Toxicity, e tatau ona gauai atu i le taotoga. E masani lava, 1 ~ 5mg o le phenylmercury acetate e mafai ona faʻaopopo i le fofo ile lita ole fua.
7. Faʻatinoga o le membrane hydroxypropyl methylcellulose
O le faatinoga o le hydroxypropyl methylcellulose film Hydroxypropyl methylcellulose o loʻo i ai mea sili ona lelei e fai ata tifaga. O lona vaifofo vai po'o se vaifofo fa'ameaola e ufiufi i luga o se ipu tioata, ma e le lanu ma manino pe a uma ona fa'agogo. Ma ata tifaga faigata. E lelei le susū e tete'e ma tumau mausali i le vevela maualuga. Afai e faʻaopoopoina le plasticizer hygroscopic, e mafai ona faʻaleleia lona faʻalauteleina ma le fetuutuunai. I tulaga o le faʻaleleia atili o le fetuutuunai, o mea faʻapipiʻi e pei o le glycerin ma le sorbitol e sili ona talafeagai. E masani lava, o le fofo o le 2% ~ 3%, ma le aofaʻi o le plasticizer o le 10% ~ 20% o le cellulose ether. Afai e maualuga tele le mea o loʻo i totonu o le plasticizer, o le a faʻaitiitia le faʻamamago colloidal i le maualuga o le susu. O le malosi faʻamalosi o le ata faʻapipiʻi faʻatasi ma le plasticizer e sili atu le tele nai lo le leai o se faʻaopoopoga, ma faʻateleina i le faʻaopoopoga o le aofaʻi faaopoopo, ma o le hygroscopicity o le ata e faʻateleina foi i le faʻaopoopoga o le aofaʻi o le plasticizer.
Taimi meli: Tes-19-2022