Hydroxypropyl methylcellulose (HPMC) ni ibikoresho bya polymer bikunze gukoreshwa mugutegura imiti.Bitewe nubwiza buhebuje bwumubiri nubumashini, bigira uruhare runini mugukora ibinini.HPMC irashobora gukoreshwa nka firime yahoze, igenzurwa nogusohora, gufatira, kubyimba, nibindi, guha ibinini imiterere n'imikorere.
1. Filime yambere
Uruhare rwa HPMC nka firime yambere rugaragarira cyane cyane hejuru yubuso bwibisohoka bigenzurwa.Ipitingi ya tablet ikorwa hagamijwe kugenzura igipimo cyo kurekura ibiyobyabwenge, kurinda ibiyobyabwenge ingaruka z’ibidukikije, no kunoza isura y’ibiyobyabwenge.Mu myiteguro yo gusohora igenzurwa, firime yakozwe na HPMC irashobora guhindura igipimo cyo gusohora imiti, ikemeza ko imiti irekurwa mubice bimwe na bimwe byigifu, kandi ikagera ku ngaruka nziza zo kuvura.
Uburyo bwibikorwa: Filime yakozwe na firime ya HPMC yambere irashobora kugera kurekurwa kugenzura ibiyobyabwenge mugucunga ibyinjira no gusesa ibiyobyabwenge.Umubyimba hamwe nibigize firime birashobora guhindura igipimo cyo guseswa kugirango byuzuze ibisabwa byo gusohora imiti itandukanye.
Ingaruka: Ibinini bifashisha HPMC nk'umuntu ukora firime birashobora gushonga buhoro mu gifu, birinda kurekura ibiyobyabwenge bitunguranye, kunoza ikoreshwa ry'ibiyobyabwenge, no kugabanya uburakari bw'ibiyobyabwenge mu nzira ya gastrointestinal.
2. Kugenzura umukozi wo kurekura
HPMC ikoreshwa nkibikoresho bya matrix mububiko bugenzurwa-kurekura kugirango igabanye igipimo cyo gusohora imiti ikora inzitizi ya gel.Uruhare rwumukozi urekura-kurekura ni ukureba niba ibiyobyabwenge bisohoka mu gihe runaka kugira ngo ibiyobyabwenge bigabanuke neza mu mubiri, kugabanya inshuro zifata, no kunoza iyubahirizwa ry’abarwayi.
Uburyo bwibikorwa: Mubitangazamakuru byamazi, HPMC irashobora guhita ihindura kandi igakora imiyoboro ihuza imiyoboro, igenzura ikwirakwizwa ryikwirakwizwa ryibiyobyabwenge.Iyo tablet ihuye namazi, HPMC ikurura amazi ikabyimba kugirango igire urwego rwa gel, aho ibiyobyabwenge bitandukana mumubiri, kandi igipimo cyo kurekura giterwa nubunini nubucucike bwurwego rwa gel.
Ingaruka: HPMC nk'umukozi ugenzurwa-urekura irashobora guhagarika igipimo cyo kurekura ibiyobyabwenge, kugabanya ihindagurika ry’imiti y’amaraso, kandi bigatanga ingaruka zihamye zo kuvura, cyane cyane ku miti yo kuvura indwara zidakira.
3. Binders
Muburyo bwo gutegura ibinini, HPMC ikoreshwa kenshi nka binder kugirango yongere imbaraga zumukanishi wibinini kandi urebe neza ubusugire bwibinini mugihe cyo kubika, gutwara no kuyobora.
Uburyo bwibikorwa: HPMC, nkumuhuza, irashobora gukora ubumwe bukomeye hagati yuduce, kuburyo ifu cyangwa ibice byahujwe bigakorwa mububiko bukomeye.Ubu buryo busanzwe bukorwa hifashishijwe ikoranabuhanga rya granulation wet, aho HPMC ishonga mugisubizo cyamazi kugirango kibe igisubizo kiboneye, kandi kigakora ibinini bihamye nyuma yo kumisha.
Ingaruka: Ihuza rya HPMC rirashobora kunoza imbaraga zo gukomeretsa no gukomera kwa tableti, kugabanya ibyago byo gusenyuka cyangwa gucikamo ibice, bityo bikazamura ubwiza nuburinganire bwibinini.
4. Inkoko
HPMC irashobora kandi gukoreshwa nkibyimbye mumyiteguro yamazi kugirango ihindure imiterere ya rheologiya yimyiteguro no kongera ububobere.
Uburyo bwibikorwa: HPMC ifite ubukonje bwinshi mumazi kandi irashobora kongera neza ububobere bwamazi, kunoza ihagarikwa ryimiterere nibiyobyabwenge, kandi ikarinda imyanda.
Ingaruka: Kongera HPMC kumiti yamazi birashobora kunoza uburinganire bwibiyobyabwenge, bigatuma ibice byibiyobyabwenge bigabanywa neza mugihe cyo kwitegura, kandi bigatanga urugero rwiza buri gihe.
Ibiranga Hydroxypropyl Methylcellulose
1. Ibyiza byumubiri nubumara
HPMC ni selile ya nonionic selulose ether ifite amazi meza hamwe nubushyuhe bwumuriro.Irashonga vuba mumazi akonje kugirango ikore igisubizo kiboneye, mugihe iyo gishyushye, igisubizo gihinduka gel.
2. Biocompatibilité
HPMC ifite biocompatibilité n'umutekano byiza, kandi ntabwo ikunda gutera ubudahangarwa bw'umubiri cyangwa ingaruka z'uburozi, bityo ikoreshwa cyane mubijyanye na farumasi n'ibiribwa.
3. Ihungabana ry’ibidukikije
HPMC ifite umutekano muke kubintu bidukikije nkubushyuhe nagaciro ka pH, kandi ntabwo ikunda kwangirika cyangwa gutandukana, ibyo bigatuma imiti ihagarara neza mugihe cyo kubika.
Ingero za Porogaramu ya HPMC muri Tableti
1. Kugenzura ibinini bisohora
Kurugero, muri nifedipine ikomeza-kurekura ibinini bikoreshwa mu kuvura hypertension, HPMC ikoreshwa nkibikoresho bya matrix kugirango igenzure buhoro buhoro ibiyobyabwenge, bigabanye inshuro z’ubuyobozi, kandi binonosore kubahiriza abarwayi.
2. Ibinini byanditseho
Mu binyobwa bisizwe na enterinike ya proton pompe inhibitor (nka omeprazole), HPMC ikora nka firime ikora firime kugirango irinde ibiyobyabwenge kurimburwa na aside gastricike kandi urebe ko imiti irekurwa neza mumara.
3. Ibinini byihuta cyane
Mu binini byihuta cyane mu kanwa kugirango bivure indwara ya rinite ya allergique, HPMC ikora nk'ibyimbye kandi bifata kugirango itange vuba kandi irekure kimwe, itezimbere uburyohe no gufata uburambe bwibiyobyabwenge.
Hydroxypropyl methylcellulose ikoreshwa cyane mugutegura ibinini bitandukanye kubera gukora firime nziza, gusohora kugenzurwa, gufatana hamwe no kubyimba.HPMC ntishobora gusa kunoza imiterere yumubiri no gutuza kwa tableti, ariko kandi irashobora guhindura uburyo bwo kuvura imiti muguhindura igipimo cyibiyobyabwenge.Hamwe niterambere ryikoranabuhanga rya farumasi, ikoreshwa rya HPMC rizagenda ritandukana, ritange amahirwe menshi yo guhanga udushya twateguwe.
Igihe cyo kohereza: Jun-27-2024