Ni irihe tandukaniro riri hagati ya methylcellulose na hydroxypropylmethylcellulose?

Methyl selulose (MC) na hydroxypropyl methyl selulose (HPMC) ni ibikomoka kuri selile ebyiri zikoreshwa cyane mu nganda, mu bwubatsi, mu bya farumasi, mu biribwa no mu zindi nzego. Nubwo bisa muburyo, bifite imitungo itandukanye kandi Hariho itandukaniro rikomeye mubikorwa no mubikorwa.

1. Itandukaniro ryimiterere yimiti

Methylcellulose (MC) na hydroxypropylmethylcellulose (HPMC) byombi bikomoka kuri selile karemano kandi byahinduwe na chimique ya selile ya ether. Ariko itandukaniro ryabo ahanini riri mubwoko n'umubare w'amatsinda asimbuye.

Methyl selulose (MC)
MC ikorwa mugusimbuza hydroxyl matsinda kuri selile hamwe na methyl matsinda (ni ukuvuga -OCH₃). Imiterere yimiti ya MC igizwe ahanini na methyl insimburangingo ya methyl kumurongo wingenzi wa selile, kandi igipimo cyayo cyo kuyisimbuza kigira ingaruka kumyuka no mumiterere. MC muri rusange ibora mumazi akonje ariko ntabwo iri mumazi ashyushye.

Hydroxypropyl methylcellulose (HPMC)
HPMC yongeye guhindurwa hashingiwe kuri methylcellulose, mugusimbuza igice cyamatsinda ya hydroxyl na methyl (-CH₃) na hydroxypropyl (-CH₂CH (OH) CH₃). Ugereranije na MC, imiterere ya molekuline ya HPMC iraruhije, hydrophilicity na hydrophobicity iringaniye neza, kandi irashobora gukemuka mumazi akonje kandi ashyushye.

2. Itandukaniro mumiterere yumubiri na chimique solubilité

MC: Methylcellulose muri rusange ifite imbaraga zo gukemura neza mumazi akonje, ariko izakora gel mugihe ubushyuhe buzamutse. Mu mazi ashyushye, MC ihinduka idashonga, ikora gel yumuriro.
HPMC: Hydroxypropyl methylcellulose irashobora gushonga kimwe mumazi akonje kandi ashyushye, ifite ubushyuhe bwinshi bwo gushonga, kandi gukomera kwayo guhamye kuruta MC.

Ubushyuhe bwumuriro
MC: MC ifite imiterere ikomeye yubushyuhe. Iyo ubushyuhe buzamutse kurwego runaka, buzakora gel kandi butakaza imbaraga. Ibi biranga bituma ikoresha bidasanzwe mubikorwa byubwubatsi n’imiti.
HR Ugereranije na MC, imiterere ya gel ya HPMC ya HPMC irashobora kugenzurwa bityo ikaba nziza cyane mubisabwa bisaba ubushyuhe bwo hejuru.

Igikorwa cyo hejuru
MC: MC ifite ibikorwa byo hasi. Nubwo ishobora gukoreshwa nka emulisiferi runaka cyangwa ikabyimbye mubikorwa bimwe na bimwe, ingaruka ntabwo zikomeye nka HPMC.
HPMC: HPMC ifite ibikorwa byubuso bukomeye, cyane cyane kwinjiza itsinda rya hydroxypropyl, ryoroshya kwigana, guhagarika no kubyimba mubisubizo. Kubwibyo, ikoreshwa cyane nkinyongera mubitambaro nibikoresho byubaka.

Kwihanganira umunyu no gutuza kwa pH
MC: Methylcellulose ifite kwihanganira umunyu muke kandi ikunda kugwa imvura ahantu h'umunyu mwinshi. Ifite umutekano muke muri aside na alkali ibidukikije kandi bigira ingaruka byoroshye kubiciro bya pH.
HPMC: Bitewe na hydroxypropyl insimburangingo, kwihanganira umunyu wa HPMC biruta cyane MC, kandi birashobora gukomeza gukomera no gutuza neza mugace ka pH, bityo rero birakwiriye kubidukikije bitandukanye.

3. Itandukaniro mubikorwa byumusaruro

Umusaruro wa MC
Methylcellulose ikorwa binyuze muri methylation reaction ya selile, mubisanzwe ikoresha methyl chloride kugirango ikore hamwe na selile ya alkaline kugirango isimbuze amatsinda ya hydroxyl muri molekile ya selile. Iyi nzira isaba kugenzura uko ibintu byifashe kugirango harebwe urwego rukwiye rwo gusimburwa, bigira ingaruka ku gukemuka hamwe nindi miterere yumubiri wibicuruzwa byanyuma.

Umusaruro wa HPMC
Umusaruro wa HPMC ushingiye kuri methylation kandi wongeraho hydroxypropylation reaction. Ni ukuvuga, nyuma ya methylation reaction ya methyl chloride, okiside ya propylene ikora hamwe na selile kugirango itange hydroxypropyl insimburangingo. Itangizwa ryitsinda rya hydroxypropyl ritezimbere ubushobozi bwa solubilité na hydrata ya HPMC, nayo ituma inzira yumusaruro igorana kandi igiciro gito ugereranije na MC.

4. Itandukaniro mubice byo gusaba

Umwanya wo kubaka ibikoresho
MC: MC ikoreshwa kenshi mubikoresho byubwubatsi, cyane cyane kubyimbye, kubika amazi no gufatisha mumashanyarazi yumye hamwe nifu ya putty. Ariko, kubera imiterere yubushyuhe bwumuriro, MC irashobora kunanirwa mubushyuhe bwo hejuru.
HPMC: HPMC ikoreshwa cyane mubikorwa byubwubatsi. Kuberako ifite kandi ituze ryiza mubushyuhe bwo hejuru, birakwiriye cyane kuri ssenariyo isaba kwihanganira ubushyuhe burenze urugero, nk'ibiti bifata tile, minisiteri yo kubitsa hamwe na etage hasi. .

Imirima yimiti nibiribwa
MC: Methylcellulose ikunze gukoreshwa nkigabanuka kandi ikabyimbye kubinini byateguwe na farumasi. Irakoreshwa kandi mubiribwa bimwe na bimwe byongera umubyimba wa fibre.
HPMC: HPMC ifite ibyiza byinshi murwego rwa farumasi. Kuberako irushijeho gukomera hamwe na biocompatibilité nziza, ikoreshwa kenshi mubikoresho bya firime bikomeza-bisohoka hamwe na capsule shell kubiyobyabwenge. Byongeye kandi, HPMC ikoreshwa cyane mu nganda z’ibiribwa, cyane cyane mu gukora capsules zikomoka ku bimera.

Imyenda yo gusiga amarangi
MC: MC ifite ingaruka nziza zo kubyimba no gukora firime, ariko ituze ryayo hamwe nubushobozi bwo guhindura ibishishwa mubisubizo ntabwo ari byiza nka HPMC.
HR . Ingaruka.

5. Kurengera ibidukikije n'umutekano

MC na HPMC zombi zahinduwe ziva muri selile karemano kandi zifite ibinyabuzima byiza kandi birinda ibidukikije. Byombi ntabwo ari uburozi kandi ntacyo bitwaye mugukoresha kandi byubahiriza ibisabwa byo kurengera ibidukikije, bityo rero ni byiza cyane gukoreshwa mubiribwa, imiti n’imiti yo kwisiga.

Nubwo methylcellulose (MC) na hydroxypropylmethylcellulose (HPMC) bisa muburyo bwimiti, kubera amatsinda atandukanye asimburana, ibisubizo byayo, ubushyuhe bwumuriro, ibikorwa byubutaka, ibikorwa byumusaruro no kubishyira mu bikorwa biratandukanye. Hariho itandukaniro rigaragara mubice nibindi bice. MC ikwiranye nubushyuhe buke hamwe nubushuhe bworoshye hamwe nibisabwa byo gufata amazi, mugihe HPMC ikwiranye ninganda zinganda, imiti n’ubwubatsi bitewe no gukemuka neza hamwe nubushyuhe bwumuriro.