HPMC (Hydroxypropyl Methylcellulose) ni ibikoresho byinshi bikoreshwa cyane muri farumasi, ibiryo, ibikoresho byubaka nizindi nzego. Ibicuruzwa bya HPMC birashobora kugabanywamo ibice byinshi ukurikije ibisabwa bitandukanye bisabwa, muribyo bikunze kugaragara ni K ikurikirana na E. Nubwo byombi ari HPMC, bifite itandukaniro runaka muburyo bwa shimi, imiterere yumubiri hamwe nimirima ikoreshwa.
1. Itandukaniro ryimiterere yimiti
Methoxy yibirimo: Itandukaniro nyamukuru hagati yuruhererekane rwa K na E urukurikirane rwa HPMC nibirimo byimikorere. Imikorere ya metxyxy ya E seriyeri HPMC iri hejuru (muri rusange 28-30%), mugihe ibikorerwa muburyo bwa K bikurikirana ni bike (hafi 19-24%).
Hydroxypropoxy ibirimo: Ibinyuranye, hydroxypropoxy yibigize K ikurikirana (7-12%) irarenze iy'uruhererekane rwa E (4-7.5%). Iri tandukaniro mubigize imiti biganisha ku itandukaniro mubikorwa no gushyira mubikorwa hagati yombi.
2. Itandukaniro mumiterere yumubiri
Gukemura: Bitewe no gutandukanya imikorere ya hydroxypropoxy, solubilité ya K ya HPMC iri munsi gato ugereranije na E, cyane cyane mumazi akonje. Urukurikirane rwa E rushobora gushonga cyane mumazi akonje bitewe nubunini bwarwo.
Ubushyuhe bwa Gel: Ubushyuhe bwa gel bwa seri ya K burenze ubw'uruhererekane rwa E. Ibi bivuze ko mubihe bimwe, biragoye cyane K K HPMC gukora gel. Ubushyuhe bwa geli ya E iri hasi, kandi mubikorwa bimwe byihariye, nkibikoresho bya termosensitif gel, E serie irashobora gukora neza.
Viscosity: Nubwo viscosity ahanini iterwa nuburemere bwa molekuline ya HPMC, mubihe bimwe, ubwiza bwuruhererekane rwa E HPMC mubusanzwe burenze ubw'uruhererekane rwa K. Itandukaniro ryijimye rifite ingaruka zikomeye kumiterere ya rheologiya mugihe cyo kwitegura, cyane cyane iyo ikoreshejwe kuri coatings no guhagarikwa.
3. Itandukaniro mubice byo gusaba
Bitewe nuburyo butandukanye mumiterere yimiti nimiterere yumubiri ya K ikurikirana na E serie HPMC, ibyifuzo byabo mubice bitandukanye nabyo biratandukanye.
Umwanya wa farumasi: Mu myiteguro yimiti, E serie HPMC ikoreshwa nkibintu byingenzi byimyiteguro irambye. Ibi biterwa nubushyuhe buke bwa gelation hamwe nubukonje bwinshi, butuma igenzura neza igipimo cyo gusohora ibiyobyabwenge mugihe ikora firime ikomeza-gusohora. Urukurikirane rwa K rukoreshwa cyane mubinini byometse kuri enteric kandi nkibikoresho byurukuta rwa capsule, kubera ko ubushyuhe bwabyo bwo hejuru bwa gelation bubuza irekurwa ryibiyobyabwenge mumitobe ya gastrica, bifasha kurekura ibiyobyabwenge mumara.
Umurima wibiribwa: Mu nganda zibiribwa, E serie HPMC ikoreshwa nkibyimbye, stabilisateur na emulifier. Bitewe no gukomera kwinshi hamwe nubukonje bukwiye, birashobora gutatana neza no gushonga mubiryo. Urukurikirane rwa K rukoreshwa cyane mubiribwa bikeneye kugumya gutuza mubihe byubushyuhe bwinshi, nkibicuruzwa bitetse, bitewe nubushyuhe bwacyo bwinshi.
Umwanya wo kubaka ibikoresho: Mubikoresho byubwubatsi, K seri ya HPMC isanzwe ikoreshwa mumashanyarazi yumye hamwe nifu ya putty, ikora nkigumana amazi kandi ikabyimbye, cyane cyane mubihe bigomba kubakwa mubushyuhe bwinshi. Urukurikirane rwa E rurakwiriye cyane kubikoresho bifite imiterere-karemano ya rheologiya nko gusiga irangi hasi no gutwikira bitewe n'ubushyuhe buke bwa gelation hamwe n'ubukonje bwinshi.
4. Ibindi bintu bigira ingaruka
Usibye itandukaniro ryavuzwe haruguru, imikoreshereze yihariye yuruhererekane rwa HPMC irashobora kandi guterwa nimpamvu nkuburemere bwa molekile, urugero rwo gusimburwa, no gutandukana. Mubyongeyeho, mubikorwa bifatika, guhitamo HPMC nabyo bigomba gutekereza kubihuza nibindi bikoresho n'ingaruka zabyo kumikorere yibicuruzwa byanyuma.
Nubwo urukurikirane rwa K na E urukurikirane rwa HPMC byombi hydroxypropyl methylcellulose, byerekana itandukaniro rigaragara mumiterere yumubiri hamwe n’ahantu hashyirwa mubikorwa bitewe nibintu bitandukanye bigize methoxy na hydroxypropoxy. Gusobanukirwa itandukaniro nibyingenzi muguhitamo ubwoko bwiza bwa HPMC mubikorwa bifatika.
Igihe cyo kohereza: Kanama-13-2024