Hydroxypropylmethylcellulose isimbuwe cyane (L-HPMC) ni polymer zitandukanye, zitandukanye kandi zikoreshwa mubikorwa bitandukanye, harimo imiti, ibiryo, ubwubatsi, no kwisiga. Uru ruganda rukomoka kuri selile, polymer karemano iboneka murukuta rw'ibimera. Kugira ngo usobanukirwe na hydroxypropyl methylcellulose, umuntu agomba gusenya izina rye akanashakisha imiterere, imikoreshereze, synthesis, n'ingaruka ku nganda zitandukanye.
1. Gusobanukirwa amazina:
Hydroxypropyl methylcellulose (HPMC):
Cellulose ni karubone nziza igizwe na glucose kandi ni igice cyingenzi cyinkuta za selile.
Hydroxypropyl methylcellulose nuburyo bwahinduwe bwa selile yavuwe muburyo bwo kumenyekanisha hydroxypropyl na methyl. Ihinduka ryongerera imbaraga hamwe nibindi bintu byifuzwa.
Gusimburwa hasi:
Yerekeza ku kigero cyo hasi cyo gusimburwa ugereranije n’ibindi bikomoka kuri selile, nkibikomoka cyane cyane nka hydroxyethyl selulose (HEC).
2. Imikorere:
Gukemura:
L-HPMC irashonga cyane mumazi kuruta selile.
Viscosity:
Ubwiza bwibisubizo bya L-HPMC burashobora kugenzurwa muguhindura urwego rwo gusimbuza, bigatuma bikwiranye nurwego runini rwa porogaramu.
Gushinga firime:
L-HPMC irashobora gukora firime yoroheje, ikagira akamaro muburyo butandukanye bwo gutwikira.
Ubushyuhe bukabije:
Muri rusange polymer yerekana neza ubushyuhe bwumuriro, bigira uruhare muburyo butandukanye mubikorwa bitandukanye.
3. Synthesis:
Etherification:
Synthesis ikubiyemo etherification ya selile hamwe na okiside ya propylene kugirango itangize amatsinda ya hydroxypropyl.
Methylation ikurikiraho hamwe na methyl chloride yongera amatsinda ya methyl mumugongo wa selile.
Urwego rwo gusimbuza rushobora kugenzurwa mugihe cya synthesis kugirango ubone ibintu wifuza.
4. Gusaba:
A. Inganda zimiti:
Guhambira no gutandukana:
Byakoreshejwe nkibihuza muburyo bwa tablet kugirango uhuze ibikoresho hamwe.
Ibikorwa nkibidahwitse kugirango duteze imbere gusenya ibinini muri sisitemu yo kurya.
Kurekurwa kuramba:
L-HPMC ikoreshwa muburyo bugenzurwa-kurekura, bigatuma imiti irekurwa buhoro buhoro mugihe runaka.
Imyiteguro yibanze:
Biboneka mu mavuta, geles n'amavuta, bitanga ubwiza kandi bitezimbere ikwirakwizwa rya formula.
B. Inganda zibiribwa:
Thickener:
Yongera ubwiza bwibiryo kandi atezimbere ubwiza numunwa.
stabilisateur:
Kuzamura ituze rya emulisiyo no guhagarikwa.
Gushinga firime:
Filime ziribwa zo gupakira ibiryo.
C. Inganda zubaka:
Mortar na sima:
Ikoreshwa nkibikoresho bigumana amazi mubikoresho bishingiye kuri sima.
Kunoza imikorere no gufatira minisiteri.
D. Amavuta yo kwisiga:
Ibicuruzwa byita ku muntu:
Biboneka muri cream, amavuta yo kwisiga hamwe na shampo kugirango bifashe kunoza imiterere no gutuza.
Ikoreshwa nkumukozi ukora firime mumavuta yo kwisiga.
5. Kugenzura:
FDA Yemejwe:
L-HPMC muri rusange izwi nk’umutekano (GRAS) n’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA).
Kubahiriza ibipimo ngenderwaho ni ngombwa mu gukoresha imiti n'ibiribwa.
6. Ibibazo hamwe nigihe kizaza:
Ibinyabuzima bigabanuka:
Nubwo polimeri ishingiye kuri selile isanzwe ifatwa nkibinyabuzima, urugero rwibinyabuzima biva mu ngirabuzimafatizo byahinduwe bisaba ko hakorwa iperereza rindi.
Kuramba:
Isoko rirambye ryibikoresho fatizo nuburyo bwangiza ibidukikije nuburyo bukomeza kwibandwaho.
7. Umwanzuro:
Hydroxypropyl methylcellulose isimbuwe nkeya yerekana ubuhanga bwo guhindura imiti mugukoresha imiterere ya polymers karemano. Porogaramu zinyuranye mu nganda zitandukanye zigaragaza akamaro kazo mu nganda zigezweho. Nkuko iterambere ryikoranabuhanga hamwe no kuramba bifata umwanya wambere, gukomeza gushakisha no gutunganya L-HPMC nibindi bisa bishobora guhindura ejo hazaza hibikoresho siyanse nibikorwa byinganda.
Igihe cyo kohereza: Ukuboza-26-2023