Hydroxypropylcellulose (HPC) ni intungamubiri ikomoka kuri selile, polymer karemano iboneka mu nkuta z’ibimera. Umusaruro wa hydroxypropylcellulose urimo guhindura imiti ya selile ukoresheje urukurikirane rwibisubizo. Ihinduka ritanga selile yihariye ituma iba ingirakamaro mubikorwa bitandukanye byinganda na farumasi.
Imiterere ya hydroxypropylcellulose:
Hydroxypropylcellulose ni hydroxyalkyl ikomoka kuri selile aho itsinda rya hydroxypropyl rifatanije numugongo wa selile. Umugongo wa selile ubwayo ni urunigi rw'umurongo wa glucose uhujwe na β-1,4-glycosidic. Amatsinda ya Hydroxypropyl atangizwa no gukora selile hamwe na oxyde ya propylene imbere ya catalizike ya alkaline.
Urwego rwo gusimbuza (DS) ni ikintu cy'ingenzi gisobanura imiterere ya hydroxypropylcellulose. Yerekana impuzandengo yimibare ya hydroxypropyl kumatsinda ya glucose murwego rwa selile. DS irashobora kugenzurwa mugihe cya synthesis, itanga umusaruro wa hydroxypropylcellulose hamwe nintera zitandukanye zo gusimbuza kugirango zuzuze ibisabwa byihariye.
Synthesis ya hydroxypropylcellulose:
Synthesis ya hydroxypropylcellulose ikubiyemo reaction hagati ya selile na okiside ya propylene. Iyi reaction isanzwe ikorwa imbere ya catalizator yibanze nka sodium hydroxide. Imisemburo ya alkaline iteza imbere gufungura impeta ya epoxy muri okiside ya propylene, bigatuma hiyongeraho amatsinda ya hydroxypropyl kumurongo wa selile.
Ubusanzwe reaction ikorwa mumashanyarazi kandi ubushyuhe nigihe cyo kubyitwaramo bigenzurwa neza kugirango ugere kurwego rwifuzwa rwo gusimburwa. Nyuma yo kubyitwaramo, ibicuruzwa mubisanzwe bisukurwa binyuze mubikorwa nko gukaraba no kuyungurura kugirango ukureho reagent zose zidakozwe cyangwa ibicuruzwa.
Ibiranga Hydroxypropyl Cellulose:
Gukemura: Hydroxypropylcellulose irashonga mumashanyarazi atandukanye, harimo amazi, Ethanol, hamwe ninshi mumashanyarazi. Iyi mitungo ya solubility ituma ikwiranye na progaramu zitandukanye.
Viscosity: Ongeramo hydroxypropyl matsinda muri selile yongerera imbaraga kandi ihindura imitekerereze ya polymer. Ibi bituma hydroxypropylcellulose ifite agaciro mumiti ya farumasi, akenshi nkumubyimba cyangwa geli.
Imiterere ya Firime: Hydroxypropylcellulose irashobora gukora firime yoroheje kandi ikorera mu mucyo, bigatuma ikwirakwizwa, firime kandi nkumuhuza mugutegura ibinini.
Ubushyuhe bwa Thermal: Hydroxypropylcellulose ifite ituze ryiza ryumuriro, ryemerera gukoreshwa mubikorwa bitandukanye byinganda nta kwangirika gukomeye.
Guhuza: Irahujwe nizindi polymers zitandukanye hamwe nibisohoka, byongera akamaro kayo mumiti yimiti no kwisiga.
Porogaramu ya Hydroxypropyl Cellulose:
Imiti ya farumasi: Hydroxypropylcellulose ikoreshwa cyane munganda zimiti nkumuhuza mugutegura ibinini, uhindura viscosity muburyo bwa dosiye, hamwe numukozi ukora firime mubitambaro kumpapuro zifata umunwa.
Ibicuruzwa byita ku muntu ku giti cye: Mu mavuta yo kwisiga hamwe n’ibicuruzwa byita ku muntu ku giti cye, hydroxypropylcellulose ikoreshwa nk'umubyimba, stabilisateur ndetse nogukora firime mubicuruzwa nka cream, amavuta yo kwisiga hamwe no gutunganya umusatsi.
Inganda zikoreshwa mu nganda: Bitewe no gukora firime no gufatira hamwe, hydroxypropylcellulose irashobora gukoreshwa mubikorwa bitandukanye byinganda, harimo ibifuniko, ibifunga kandi nkibikoresho byo gukora ibintu bibumbabumbwe.
Inganda z’ibiribwa: Mu nganda z’ibiribwa, hydroxypropylcellulose irashobora gukoreshwa nkibyimbye hamwe na stabilisateur mu biryo bimwe na bimwe.
Inganda z’imyenda: Hydroxypropyl selulose irashobora gukoreshwa mu nganda z’imyenda hamwe nogukora firime no gufatira hamwe kugirango ifashe kurangiza imyenda.
Hydroxypropyl selulose ni selile yahinduwe ikoreshwa cyane muri farumasi, ibicuruzwa byita ku muntu, hamwe n’inganda zitandukanye zikoreshwa mu nganda bitewe no gukemuka kwayo, ibintu bihindura viscosity, ubushobozi bwo gukora firime, no guhuza nibindi bikoresho bikoreshwa. Guhinduranya kwinshi hamwe no kugenzura bigizwe na polymer ifite agaciro mubikorwa bitandukanye.
Igihe cyo kohereza: Ukuboza-26-2023