Ni izihe ngaruka ubushyuhe bugira ku bwiza bwumuti wamazi wa HPMC?

Hydroxypropyl Methylcellulose (HPMC) ni polymer yingenzi ibora amazi ikoreshwa cyane muri farumasi, ibiryo, ibifuniko, ibikoresho byubaka nizindi nzego. Igisubizo cyibisubizo bya HPMC nikintu cyingenzi kigira ingaruka kumikorere no kuyishyira mubikorwa, kandi ubushyuhe bugira ingaruka zikomeye kumyuka yumuti wamazi wa HPMC.

1. Ibiranga Viscosity biranga igisubizo cya HPMC
HPMC ni ibikoresho bya polymer hamwe nubushyuhe bwo guhindagurika. Iyo HPMC yashongeshejwe mumazi, igisubizo cyamazi cyakozwe kigaragaza ibiranga amazi atari Newtonian, ni ukuvuga ko ibisubizo byijimye bihinduka hamwe nihinduka ryikigereranyo. Ku bushyuhe busanzwe, ibisubizo bya HPMC mubisanzwe bitwara nkamazi ya pseudoplastique, ni ukuvuga ko afite ubukonje bwinshi ku gipimo gito cyogosha, kandi ubukonje bukagabanuka uko igipimo cyogosha cyiyongera.

2. Ingaruka yubushyuhe ku bwiza bwumuti wa HPMC
Imihindagurikire yubushyuhe ifite uburyo bubiri bwingenzi bugira ingaruka kumyuka ya HPMC ibisubizo byamazi: kongera ubushyuhe bwumuriro wumunyururu wa molekile hamwe nimpinduka mubikorwa.

(1) Ubushuhe bwubushyuhe bwiminyururu ya molekile iriyongera
Iyo ubushyuhe bwiyongereye, umuvuduko wubushyuhe wa HPMC urunigi rwiyongera, ibyo bigatuma imiyoboro ya hydrogène hamwe na van der Waals imbaraga hagati ya molekile zigabanuka kandi amazi yumuti yiyongera. Ubukonje bwigisubizo buragabanuka bitewe no kugabanuka kwifata no guhuza umubiri guhuza iminyururu ya molekile. Kubwibyo, HPMC ibisubizo byamazi byerekana ububobere buke mubushyuhe bwinshi.

(2) Impinduka mubikorwa byo gukemura
Imihindagurikire yubushyuhe irashobora kugira ingaruka kumyuka ya molekile ya HPMC mumazi. HPMC ni polymer ifite imiterere ya thermogelling, kandi gukomera kwayo mumazi guhinduka cyane hamwe nubushyuhe. Ubushyuhe bwo hasi, amatsinda ya hydrophilique kumurongo wa molekile ya HPMC akora hydrogène ihamye hamwe na molekile zamazi, bityo bikomeza gushonga neza hamwe nubukonje bwinshi. Nyamara, iyo ubushyuhe buzamutse kurwego runaka, imikoranire ya hydrophobi hagati yiminyururu ya molekile ya HPMC irazamurwa, bigatuma habaho imiterere yimiterere yibice bitatu cyangwa gelation mubisubizo, bigatuma ubukonje bwibisubizo bwiyongera muburyo butunguranye mubihe bimwe na bimwe. Iyi phenomenon yitwa Ni "ubushyuhe bwa gel".

3. Kwihweza ubushakashatsi bwubushyuhe kuri HPMC igisubizo cyiza
Ubushakashatsi bwakozwe bwerekanye ko mubushyuhe busanzwe (urugero, 20 ° C kugeza 40 ° C), ubwiza bwibisubizo byamazi ya HPMC bigenda bigabanuka buhoro buhoro hamwe nubushyuhe bwiyongera. Ni ukubera ko ubushyuhe bwo hejuru bwongera imbaraga za kinetic zumunyururu wa molekile kandi bikagabanya imikoranire hagati yimitsi, bityo bikagabanya guterana imbere kwumuti. Nyamara, iyo ubushyuhe bukomeje kwiyongera kugeza kuri gel yumuriro wa HPMC (mubisanzwe hagati ya 60 ° C na 90 ° C, bitewe nurwego rwo gusimbuza nuburemere bwa molekile ya HPMC), ubukonje bwumuti bwiyongera gitunguranye. Ibibaho byibi bintu bifitanye isano no guterana no kwegeranya iminyururu ya HPMC.

4. Isano iri hagati yubushyuhe na HPMC ibipimo byubaka
Umuti wibisubizo bya HPMC ntabwo uterwa nubushyuhe gusa, ahubwo ufitanye isano rya hafi nimiterere ya molekile. Kurugero, urwego rwo gusimbuza (urugero, ibirimo hydroxypropyl na methyl insimburangingo) hamwe nuburemere bwa molekuline ya HPMC bigira ingaruka zikomeye kumyitwarire ya gel yumuriro. HPMC ifite urwego rwo hejuru rwo gusimbuza igumana ubukonje buke mu bipimo by'ubushyuhe bwagutse bitewe n’amatsinda menshi ya hydrophilique, mu gihe HPMC ifite urwego ruto rwo gusimbuza birashoboka cyane gukora gele yumuriro. Byongeye kandi, HPMC ibisubizo bifite uburemere buke bwa molekuline birashoboka cyane kwiyongera mubwiza bwubushyuhe bwinshi.

5. Ibitekerezo byinganda ningamba zifatika
Mubikorwa bifatika, ubwoko bwa HPMC bukwiye gutoranywa ukurikije ubushyuhe bwihariye. Kurugero, mubihe byubushyuhe bwo hejuru, HPMC hamwe nubushyuhe bwo hejuru ikeneye guhitamo kugirango wirinde ubushyuhe bwumuriro. Mugihe cy'ubushyuhe buke, gukemura no gukomera kwa HPMC bigomba kwitabwaho.

Ingaruka yubushyuhe ku bwiza bwa HPMC igisubizo cyamazi gifite akamaro gakomeye. Mu rwego rwa farumasi, HPMC ikoreshwa nkibikoresho bisohora-bitegura imiti, kandi ibiranga ububobere bwayo bigira ingaruka ku buryo bwo kurekura ibiyobyabwenge. Mu nganda z’ibiribwa, HPMC ikoreshwa mu kunoza imiterere n’ibicuruzwa, kandi ubushyuhe bushingiye ku bushyuhe bw’ibisubizo byabwo bigomba guhinduka ukurikije ubushyuhe bwo gutunganya. Mu bikoresho byubwubatsi, HPMC ikoreshwa nkibikoresho byiyongera kandi bigumana amazi, kandi ibiranga ubwiza bwayo bigira ingaruka kumikorere yubwubatsi nimbaraga zibintu.

Ingaruka yubushyuhe ku bwiza bwumuti wamazi wa HPMC ninzira igoye irimo umuvuduko wubushyuhe bwurunigi rwa molekile, imikoranire yumuti, hamwe nimiterere ya polymer. Muri rusange, ubwiza bwibisubizo byamazi ya HPMC muri rusange bigabanuka hamwe nubushyuhe bwiyongera, ariko mubushuhe bumwe na bumwe, ubushyuhe bwumuriro burashobora kubaho. Gusobanukirwa ibi biranga bifite akamaro gakomeye kayobora kubikorwa bifatika no gutezimbere HPMC.