Hydroxypropylmethylcellulose (HPMC) ni polymer yimikorere myinshi ikomoka kuri selile ikoreshwa cyane mubikorwa bitandukanye kubera imiterere yihariye. Uruvange rwinjizwamo binyuze murukurikirane rwo guhindura imiti kuri selile, polymer karemano iboneka murukuta rwibimera.
ibikoresho fatizo:
Inkomoko: Cellulose ni ibikoresho nyamukuru bya HPMC, byuzuye muri kamere kandi bivanwa mu bimera. Ibiti by'ibiti hamwe n'ipamba ni isoko ya selile.
Kwigunga: Igikorwa cyo gukuramo kirimo gusenya urukuta rw'ibimera no gutandukanya fibre selile. Uburyo butandukanye bwimiti nubukanishi burashobora gukoreshwa kubwiyi ntego.
Okiside ya propylene:
Inkomoko: Oxyde ya Propylene ni organic organic ikomoka kuri peteroli.
Imikorere: Okiside ya Propylene ikoreshwa mugutangiza amatsinda ya hydroxypropyl muri molekile ya selile mugihe cyo guhuza, kongera imbaraga zamazi no guhindura imiterere yumubiri wa HPMC.
Methyl chloride:
Inkomoko: Methyl chloride ni hydrocarubone ya chlorine ishobora guhurizwa muri methanol.
Imikorere: Methyl chloride ikoreshwa mugutangiza amatsinda ya methyl muri molekile ya selile, bigira uruhare muri hydrophobicity muri HPMC.
Hydroxide ya Sodium (NaOH):
Inkomoko: Sodium hydroxide, izwi kandi nka soda ya caustic, ni ishingiro rikomeye kandi iraboneka mubucuruzi.
Imikorere: NaOH ikoreshwa muguhagarika reaction no guhindura pH agaciro ka reaction ivanze mugihe cya synthesis.
Synthesis:
Synthesis ya HPMC ikubiyemo intambwe nyinshi, kandi gahunda yo kubyitwaramo irashobora kuvunagurwa muburyo bukurikira:
Alkalizing:
Cellulose ivurwa na hydroxide ya sodium kugirango itange selile ya alkaline.
Alkali selulose noneho ikorwa na oxyde ya propylene kugirango itangire hydroxypropyl.
Methylation:
Hydroxypropylated selulose irongera ikorwa na methyl chloride kugirango itangire amatsinda ya methyl.
Iyi ntambwe itanga polymer yinyongera ituje hamwe na hydrophobicity.
Kutabogama no kuyungurura:
Uruvangitirane rwa reaction rwabangamiwe kugirango rukureho ishingiro rirenze.
Filtration yakozwe kugirango itandukanya selile yahinduwe.
Gukaraba no gukama:
Ibicuruzwa bitandukanijwe byogejwe hanyuma byumishwa kugirango ubone hydroxypropyl methylcellulose mubifu cyangwa muburyo bwa granular.
Ibiranga ibisubizo bya HPMC:
HPMC irashobora gushonga amazi kandi imbaraga zayo zirashobora guhinduka ukurikije urwego rwo gusimbuza hydroxypropyl na methyl.
Ubushobozi bwo gukora film:
HPMC ikora firime yoroheje, ibonerana ikwiranye ninganda zikora imiti n’ibiribwa.
Viscosity:
Ubukonje bwibisubizo bya HPMC burashobora kugenzurwa kandi bukoreshwa kenshi nkibintu byabyimbye kandi byera muburyo butandukanye.
Ubushyuhe bwa Thermal:
Ibyiciro bimwe bya HPMC byerekana imiterere ya thermogelling, ikora gel iyo ishyushye ikagaruka kubisubizo iyo bikonje.
Igikorwa cyo hejuru:
HPMC irashobora gukoreshwa nka surfactant, kandi ibikorwa byayo byo hejuru bigira ingaruka kurwego rwo gusimburwa.
Imiti ikoreshwa ya HPMC:
HPMC ikoreshwa cyane mubikorwa bya farumasi nka binders, disintegrants, hamwe nubushakashatsi bugenzurwa muri tableti na capsules.
Inganda zubaka:
Mu rwego rwubwubatsi, HPMC ikoreshwa nkibyimbye mubicuruzwa bishingiye kuri sima nka minisiteri hamwe na tile.
inganda z'ibiribwa:
HPMC ikoreshwa mu nganda zibiribwa nkibibyimbye, emulisiferi na stabilisateur mubicuruzwa bitandukanye, birimo isosi, desert na ice cream.
Ibicuruzwa byita ku muntu:
Mu mavuta yo kwisiga hamwe n’ibicuruzwa byita ku muntu ku giti cye, HPMC ikoreshwa mu kwisiga nka cream, amavuta yo kwisiga hamwe na shampo kubera kubyimbye no gutuza.
Irangi hamwe n'ibifuniko:
HPMC yongewe kumarangi no gutwikira kugirango igenzure neza, itezimbere imikoreshereze kandi itezimbere imiterere ya firime.
Ibisubizo by'amaso:
HPMC ikoreshwa mubitonyanga byamaso n'amarira yubukorikori bitewe na biocompatibilité hamwe na mucoadhesive.
mu gusoza:
Hydroxypropylmethylcellulose (HPMC) ni polymer idasanzwe ikomatanyirijwe hamwe na selile ishobora kuvugururwa. Imiterere yimikorere myinshi hamwe nuburyo bwinshi bwo kuyikoresha bituma iba ingenzi mu nganda zinyuranye, kuva muri farumasi kugeza mubwubatsi n'ibiribwa. Muguhitamo neza ibikoresho fatizo no kugenzura ibipimo bya synthesis, HPMCs ifite imitungo yihariye irashobora kubyara kugirango ihuze ibyifuzo byihariye bya porogaramu zitandukanye. Mugihe ikoranabuhanga nibikenewe bikomeje kugenda bitera imbere, HPMC irashobora gukomeza kugira uruhare runini mu guhanga udushya no guteza imbere ibicuruzwa birambye mu nganda.
Igihe cyo kohereza: Ukuboza-18-2023