Hydroxypropyl methylcellulose (HPMC) ni ether ya selile ikomeye, ikoreshwa cyane mubwubatsi, ubuvuzi, ibiryo, imiti ya buri munsi nizindi nzego. HPMC ni polymer yamazi yabonetse yabonetse muguhindura imiti ya selile naturel, hamwe nibintu byinshi byiza byumubiri nubumara.
1. Imiterere yumubiri
Kugaragara na morphologie: Ubusanzwe HPMC ni ifu yera cyangwa nkeya yumuhondo, impumuro nziza, uburyohe, kandi ifite amazi meza. Irashobora gukora firime imwe cyangwa gel ikoresheje uburyo butandukanye bwo gutunganya, bigatuma ikora neza mubikorwa byinshi.
Gukemura: HPMC irashobora gushonga byoroshye mumazi akonje, ariko ntigashonga mumazi ashyushye. Iyo ubushyuhe bugeze kurwego runaka (mubisanzwe 60-90 ℃), HPMC itakaza imbaraga zo mumazi ikora gel. Uyu mutungo urawushoboza gutanga ingaruka zibyibushye iyo zishyushye, hanyuma ugasubira mubisubizo byamazi byamazi nyuma yo gukonja. Mubyongeyeho, HPMC irashonga igice mumashanyarazi kama nka Ethanol.
Viscosity: Ubukonje bwibisubizo bya HPMC nimwe mubintu byingenzi bifatika. Ubukonje buterwa nuburemere bwa molekuline hamwe nubushakashatsi bwibisubizo. Muri rusange, uko uburemere bwa molekile nini, niko ubwiza bwibisubizo. HPMC ifite ubunini bwinshi kandi irashobora guhindurwa ukurikije ibisabwa byihariye bisabwa, bigatuma ikoreshwa cyane mubwubatsi, imiti, imiti ya buri munsi nizindi nganda.
Umutungo wo gukora firime: HPMC ifite umutungo mwiza wo gukora film. Irashobora gukora firime ibonerana kandi ikomeye nyuma yo gushonga mumazi cyangwa kumashanyarazi. Filime ifite amavuta meza hamwe n’ibinure, bityo ikoreshwa kenshi nkibikoresho byo gutwikira mu biribwa no mu bya farumasi. Byongeye kandi, firime ya HPMC ifite kandi imbaraga zo kurwanya ubushuhe kandi irashobora kurinda neza ibintu byimbere imbere.
Ubushyuhe bwumuriro: HPMC ifite ubushyuhe bwiza bwumuriro. Nubwo itakaza imbaraga kandi igakora gel ku bushyuhe bwo hejuru, ifite ubushyuhe buhebuje bwumuriro mugihe cyumye kandi irashobora kwihanganira ubushyuhe bwo hejuru butabora. Iyi mikorere itanga akarusho mugutunganya ubushyuhe bwo hejuru.
2. Imiterere yimiti
Imiti ihamye: HPMC ifite imiti ihamye yubushyuhe bwicyumba kandi irahagaze neza kuri acide, alkalis nu munyu. Kubwibyo, muburyo bwinshi bwimiti cyangwa sisitemu yo gukora, HPMC irashobora kubaho nka stabilisateur kandi ntabwo byoroshye kubyitwaramo nibindi bintu.
pH itajegajega: HPMC ikomeza guhagarara neza murwego rwa pH 2-12, bigatuma ikoreshwa mubidukikije bitandukanye bya pH. HPMC ntizigera ihura na hydrolysis cyangwa iyangirika mubihe bya acide cyangwa alkaline, bigatuma ikoreshwa cyane mubiribwa, ubuvuzi, no kwisiga.
Biocompatibilité and non-toxicity: HPMC ifite biocompatibilité nziza kandi irashobora gukoreshwa neza mubuvuzi, ibiryo ndetse nizindi nzego zifite ibisabwa cyane mubuzima bwabantu. HPMC ntabwo ari uburozi kandi ntigutera uburakari, kandi ntizacika mo molekile ntoya na enzymes zifungura umubiri, bityo irashobora gukoreshwa nkigikoresho cyo kurekura ibiyobyabwenge cyangwa kubyimbye ibiryo.
Guhindura imiti: HPMC ikubiyemo umubare munini wamatsinda ya hydroxyl mumiterere yayo, ishobora kunozwa cyangwa igahabwa imitungo mishya muguhindura imiti. Kurugero, mugukora hamwe na aldehydes cyangwa acide organic, HPMC irashobora gutegura ibicuruzwa bifite ubushyuhe bwinshi cyangwa birwanya amazi. Mubyongeyeho, HPMC irashobora kandi kuvangwa nizindi polymers cyangwa inyongeramusaruro kugirango ikore ibikoresho byinshi kugirango ihuze ibyifuzo bya porogaramu zihariye.
Ubushuhe bwa adsorption: HPMC ifite hygroscopique ikomeye kandi irashobora gukuramo ubuhehere buturuka mu kirere. Uyu mutungo wemerera HPMC kubyimba no kugenzura ubuhehere bwibicuruzwa mubisabwa bimwe. Nubwo bimeze bityo ariko, hamwe na hamwe, kwinjiza cyane kurenza urugero bishobora kugira ingaruka ku bicuruzwa bihagaze neza, bityo rero ingaruka z’ubushuhe bw’ibidukikije ku mikorere ya HPMC zigomba kwitabwaho igihe uyikoresheje.
3. Gusaba imirima nibyiza
Bitewe nimiterere yihariye yumubiri nubumashini, HPMC ifite intera nini yo gukoresha mubikorwa byinshi. Kurugero, mumurima wubwubatsi, HPMC ikoreshwa nkibikoresho byongera amazi kandi bigumana amazi kubikoresho bishingiye kuri sima kugirango bitezimbere ubwubatsi nigihe kirekire cyibikoresho byubaka; murwego rwa farumasi, HPMC ikoreshwa nkibikoresho bifata ibinini, igenzura irekura, hamwe nibikoresho bya capsule; mu murima wibiryo, ikoreshwa nkibyimbye, emulisiferi, na stabilisateur kugirango itezimbere uburyohe nibiribwa.
Hydroxypropyl methylcellulose igira uruhare rudasubirwaho mu nganda nyinshi kubera imiterere myiza yumubiri n’imiti. Imikorere idasanzwe mu gukemura amazi, ibintu bikora firime, imiterere yimiti, nibindi bituma HPMC ari ibikoresho byingirakamaro mubikorwa byinshi mubikorwa byinganda nubuzima bwa buri munsi.
Igihe cyo kohereza: Kanama-22-2024