Hydroxypropyl Methylcellulose (HPMC) ni selile ya nonionic selile ikoreshwa cyane mu nganda nk'ubwubatsi, ubuvuzi, ibiryo, kwisiga no gutwikira. Ubwinshi bwabwo buturuka kumiterere yihariye ya fiziki ya chimique nko kubyimba, guhuza, gukora firime, kubika amazi no gusiga. Ibyiciro bitandukanye bya HPMC bishyirwa mubyiciro ukurikije urwego rwabasimbuye (DS) hamwe na mikorobe hamwe na hydroxypropyl, hiyongereyeho ubwiza bwabyo, ingano yubunini nubuziranenge. Aya manota atandukanye ya HPMC afite imiterere itandukanye yo gukoresha no gukoresha.
1. Ibirimo Methoxy nibirimo hydroxypropyl
Imikorere ya hydroxypropyl yibigize HPMC nikintu cyingenzi kigena imikorere yacyo. Muri rusange, ibivugwa muri HPMC biri hagati ya 19% na 30%, naho hydroxypropyl iri hagati ya 4% na 12%. HPMC ifite ibintu byinshi byo mu rwego rwo hejuru muri rusange ifite uburyo bwiza bwo gukemura no gukora firime, mugihe HPMC ifite hydroxypropyl yo hejuru ifite elastique nziza no kubika amazi. Ibipimo bigira ingaruka kumikoreshereze ya HPMC. Kurugero, mubikorwa byubwubatsi, ibintu byinshi bya mikorobe bifasha kunoza gufata neza amazi nubwubatsi bwa minisiteri; murwego rwa farumasi, hydroxypropyl iri hejuru ifasha kunoza imiterere no kurekura imiti.
Icyiciro cya Viscosity
HPMC irashobora kugabanywamo ibice bike, ubukonje buciriritse hamwe n amanota yo hejuru cyane ukurikije ubwiza bwigisubizo cyacyo. Viscosity numutungo wingenzi wumubiri wa HPMC, mubisanzwe bipimwa nubwiza bugaragara bwumuti wa 2% mumasegonda ya milliPascal (mPa.s).
Ubukonje buke HPMC (nka 5 mPa.s kugeza kuri 100 mPa.s): Ubu bwoko bwa HPMC bukoreshwa mubisabwa bisaba ingaruka zo kubyimba hasi, nk'ibitonyanga by'amaso, spray hamwe na cosmetike. Muri iyi porogaramu, ubukonje buke HPMC irashobora gutanga amazi meza no gukwirakwiza kimwe.
Ubucucike buciriritse HPMC (urugero: 400 mPa.s kugeza 2000 mPa.s): Ubucucike buciriritse HPMC bukoreshwa mubikoresho byubaka, emulisiyo hamwe na adhesifike kugirango bitange ingaruka zibyibushye, bishobora guhuza imikorere yubwubatsi nimbaraga zumubiri wibicuruzwa byanyuma.
Ubukonje bukabije HPMC (urugero: 4000 mPa.s kugeza 200.000 mPa.s): Ubukonje bukabije HPMC bukoreshwa cyane mubisabwa bisaba kubyimba cyane, nka minisiteri, ibishishwa, ibipapuro bifata neza. Muri ibyo bicuruzwa, ubukonje bwinshi bwa HPMC bufasha kunoza uburyo bwo gufata amazi, kurwanya kugabanuka no gukomera.
3. Ingano y'ibice
Ingano ya HPMC nayo igira ingaruka kubikorwa byayo. Muri rusange, HPMC irashobora kugabanywamo ibice bito kandi byiza. Agace koroheje HPMC gakoreshwa mubisabwa bisaba guseswa vuba cyangwa gutatana, mugihe agace keza HPMC gakwiriye kubicuruzwa bifite ibisabwa byinshi kugirango bigaragare cyangwa bisaba gukwirakwizwa kimwe.
HPMC ifite ingano nini: HPMC ifite ibice binini ifite umuvuduko mwinshi wo gushonga mumashanyarazi avanze yumye hamwe nindi mirima, kandi irashobora gushiraho igisubizo kimwe, bityo bikazamura umusaruro.
HPMC ifite ingano nziza: HPMC ifite ingano nziza ikoreshwa cyane mu nganda nko gusiga amarangi, gutwika no kwisiga. Irashobora gukora firime imwe ihuriweho mugihe cyo gusaba, igateza imbere ububengerane no kumva ibicuruzwa.
4. Isuku n'amanota adasanzwe
Ukurikije ibisabwa bitandukanye bisabwa, HPMC irashobora kandi kwezwa cyangwa gukora. HPMC ifite isuku nyinshi isanzwe ikoreshwa mu nganda zimiti n’ibiribwa kugirango umutekano hamwe n’ibinyabuzima bibangikanye. Mubyongeyeho, hariho HPMC zimwe zifite imirimo yihariye, nka HPMC ihuza, HPMC ivurwa hejuru, nibindi. Aya manota yihariye ya HPMC arashobora gutanga imbaraga zo kubyimba cyane, imbaraga zikomeye zo gukora firime cyangwa acide nziza na anti-alkali.
Urwego rwa farumasi HPMC: Urwego rwa farumasi HPMC rufite isuku ryinshi kandi rukwiranye na tableti, capsules hamwe nimyiteguro irekura-irekuye, ishobora kuzamura cyane igipimo cyo kurekura no guhagarara kwimiti.
Icyiciro cyibiribwa HPMC: Icyiciro cyibiribwa HPMC ikoreshwa nkibiryo byongera ibiryo, stabilisateur na emulisiferi kugirango umutekano hamwe nuburyohe bwibiryo.
Urwego rwinganda HPMC: HPMC ikoreshwa mubwubatsi, gutwikira no mubindi bice bishobora kuba birimo umwanda muke, ariko birashobora gutanga ubukungu buhanitse kandi bukora neza.
5. Imirima yo gusaba no guhitamo
Ibyiciro bitandukanye bya HPMC bikoreshwa cyane mubwubatsi, ubuvuzi, ibiryo, kwisiga no mubindi bice. Mugihe uhitamo icyiciro gikwiye cya HPMC, ibintu nkubwiza, ibiyigize, ingano yingirakamaro hamwe nubuziranenge bigomba gusuzumwa ukurikije ibikenewe bya porogaramu zihariye.
Umwanya wubwubatsi: Mubikoresho byubwubatsi, HPMC ikoreshwa cyane nkibyimbye, bigumana amazi na binder. Kubisabwa nka minisiteri yumye hamwe na tile yometse, ni urufunguzo rwo guhitamo HPMC hamwe nubwiza bukwiye hamwe no kubika amazi.
Umwanya wa farumasi: Mu myiteguro yimiti, HPMC ikoreshwa nkibikoresho bya capsule, ibikoresho bya tablet hamwe na adhesive. Birakenewe guhitamo amanota ya HPMC hamwe nibikorwa bikwiye byo gusohora ibiyobyabwenge na biocompatibilité.
Ibiribwa no kwisiga: Mu nganda z’ibiribwa n’amavuta yo kwisiga, HPMC ikoreshwa nkibyimbye kandi bigahinduka, kandi isuku n’umutekano nibyo byibanze.
Ibyiciro bitandukanye bya Hydroxypropyl Methylcellulose (HPMC) bifite inyungu zabyo hamwe nibishobora gukoreshwa mubisabwa. Gusobanukirwa no guhitamo icyiciro gikwiye cya HPMC birashobora kunoza neza imikorere nubuziranenge bwibicuruzwa kandi bigahuza ibikenerwa nibicuruzwa bitandukanye byinganda n’abaguzi.
Igihe cyo kohereza: Kanama-21-2024