Ni ibihe byiciro bitandukanye bya HPMC?

Hydroxypropyl methylcellulose (HPMC) ni polymer itandukanye ikoreshwa mu nganda zitandukanye zirimo imiti, ubwubatsi, ibiryo, no kwisiga. Nibikomoka kuri selile yerekana ibintu bitandukanye bitewe nurwego rwihariye. Ibyiciro bitandukanye bya HPMC bitandukanijwe cyane cyane nubwiza bwabyo, urwego rwo gusimbuza, ingano yingingo, nintego yihariye yo gusaba.

1. Icyiciro cya Viscosity
Viscosity nikintu cyingenzi gisobanura urwego rwa HPMC. Yerekeza kubyimbye cyangwa kurwanya umuvuduko wa HPMC. HPMC ifite ubunini bwikigereranyo kuva hasi kugeza hejuru kandi mubisanzwe bipimwa muri centipoise (cP) iyo bishonge mumazi. Bimwe mubisanzwe amanota yo kwisuzumisha arimo:

Amanota yo hasi ya viscosity (urugero, 3 kugeza kuri 50 cP): Aya manota akoreshwa mubisabwa bisaba ibisubizo bike byijimye, nko mubikorwa byibiribwa nka stabilisateur, kubyimba, cyangwa emulisiferi.

Icyiciro cyo hagati ya viscosity (urugero, 100 kugeza 4000 cP): Ubucucike buciriritse HPMC ikoreshwa mugutegekanya kurekura ibiyobyabwenge kandi nkibihuza mugukora ibinini.

Impamyabumenyi yo hejuru cyane (urugero, 10,000 kugeza 100.000 cP): Impamyabumenyi yo hejuru cyane ikoreshwa mubwubatsi, cyane cyane minisiteri ishingiye kuri sima, ibifata, hamwe na pompe, aho bitezimbere imikorere, kubika amazi, no gufatira hamwe.

2. Impamyabumenyi yo gusimbuza (DS) no gusimbuza Molar (MS)
Urwego rwo gusimbuza bivuga impuzandengo y'amatsinda ya hydroxyl kuri molekile ya selile isimburwa na mikorerexy (-OCH3) cyangwa hydroxypropyl (-OCH2CHOHCH3). Urwego rwo gusimbuza rugira ingaruka ku gukemuka, ubushyuhe bwa gelation, hamwe nubwiza bwa HPMC. Amanota ya HPMC yashyizwe mubikorwa hashingiwe kubikorwa bya hydroxypropyl:

Uburyo bwa Methoxy (28-30%): Ibiri murwego rwohejuru muri rusange bivamo ubushyuhe buke bwa gelation hamwe nubushuhe buhebuje.

Hydroxypropyl ibirimo (7-12%): Kongera hydroxypropyl muri rusange biteza imbaraga mumazi akonje kandi byongera guhinduka.

3. Kugabana ingano yubunini
Ingano yubunini bwa poro ya HPMC irashobora gutandukana cyane, bigira ingaruka kumibare yabyo no gukora mubikorwa runaka. Nibyiza ibice, niko byihuta gushonga, bigatuma bikenerwa cyane mubisabwa bisaba kwihuta vuba, nkinganda zibiribwa. Mu bwubatsi, nibyiza gukoresha amanota ya coarser kugirango ukwirakwize neza muruvange rwumye.

4. Impamyabumenyi yihariye yo gusaba
HPMC iraboneka mu byiciro bitandukanye, ijyanye n'inganda zikenewe mu nganda:

Icyiciro cya farumasi: Ikoreshwa nka binder, firime yambere, kandi igenzurwa nogusohora muburyo bukomeye bwa dosiye. Yujuje ubuziranenge bukomeye kandi mubisanzwe ifite ubwiza bwihariye nuburyo bwo gusimbuza.

Icyiciro cyubwubatsi: Iki cyiciro cya HPMC cyateguwe neza kugirango gikoreshwe muri sima nibicuruzwa bishingiye kuri gypsumu. Itezimbere kubika amazi, gukora, no gufatira mububiko, plaque, hamwe na tile. Impamyabumenyi yo hejuru cyane ikoreshwa muri kano gace.

Urwego rwibiryo: Icyiciro cyibiribwa HPMC yemerewe gukoreshwa nkibiryo byongera ibiryo (E464) kandi birashobora gukoreshwa nkibibyimbye, emulisiferi, na stabilisateur mubicuruzwa bitandukanye, harimo ibicuruzwa bitetse hamwe nabasimbuye amata. Igomba kubahiriza amabwiriza yumutekano wibiribwa kandi mubisanzwe ni muke.

Icyiciro cyo kwisiga: Mubicuruzwa byumuntu ku giti cye, HPMC ikoreshwa nkibyimbye, emulifier, na firime yahoze. Itanga uburyo bwiza kuri cream, amavuta yo kwisiga, na shampo.

5. Impamyabumenyi zahinduwe
Porogaramu zimwe zisaba amanota ya HPMC yahinduwe, aho polymer yahinduwe muburyo bwa chimique kugirango izamure ibintu byihariye:

HPMC ihuza: Ihinduka ritezimbere imbaraga za gel hamwe no gutuza muburyo bugenzurwa-kurekura.

Hydrophobic yahinduwe HPMC: Ubu bwoko bwa HPMC bukoreshwa muburyo bukenera imbaraga zo guhangana n’amazi, nko gutwika amarangi.

6. Ubushyuhe bwa Gel
Ubushyuhe bwa gel bwa HPMC nubushyuhe aho igisubizo gitangira gukora gel. Biterwa nurwego rwo gusimbuza no kwiyegeranya. Ibyiciro bitandukanye birahari bitewe n'ubushyuhe bwa gel wifuza:

Ubushyuhe buke bwa gel: Izi ntera gel mubushyuhe bwo hasi, bigatuma ikwiranye nikirere gishyushye cyangwa inganda zihariye zisaba ubushyuhe buke.

Ubushyuhe bwo hejuru bwa gel: Ibi bikoreshwa mubisabwa bisaba gel mu bushyuhe bwo hejuru, nka farumasi imwe n'imwe.

HPMC iraboneka mubyiciro bitandukanye kugirango ihuze ibyifuzo byinganda zitandukanye. Guhitamo icyiciro cya HPMC biterwa nubwiza bwifuzwa, urwego rwo gusimbuza, ingano yingingo, nibisabwa byihariye byo gusaba. Byaba bikoreshwa muri farumasi, ubwubatsi, ibiryo cyangwa kwisiga, icyiciro gikwiye cya HPMC ningirakamaro kugirango ugere kubintu byifuzwa nibikorwa mubicuruzwa byanyuma.