(1). Intangiriro
Hydroxypropyl methylcellulose (HPMC), izwi kandi nka hydroxypropyl methylcellulose, ni selile ya selelose ya selelose ether ikoreshwa na farumasi zitandukanye. Ikoreshwa rya HPMC mu rwego rwa farumasi ahanini riterwa nubwiza buhebuje bwumubiri nubumashini, harimo gukora firime, geli, kubyimba, gufatana hamwe no gutuza. Nka inert kandi idafite ionic, HPMC irashobora gutanga neza kurekurwa kugenzurwa, guhisha uburyohe, gukora firime, gufatira hamwe no kurinda imirimo mugutegura imiti.
(2). Ibigize no kwitegura
HPMC ihindurwa na methylation igice hamwe na hydroxypropylation ya selile ukoresheje etrifisation ya selile hamwe na methanol na oxyde ya propylene mubihe bya alkaline. Imiterere ya HPMC, nk'ubukonje, ubushyuhe bwa gelation hamwe na solubilité, bigira ingaruka kubibirimo nuburemere bwa molekile. Umusaruro w’urwego rwa farumasi HPMC ugomba kuba wujuje ubuziranenge bw’ubuziranenge kugira ngo usukure kandi uhuze neza n’ibisabwa n’imiti y’imiti.
(3). Imiterere yumubiri nubumara
Umutungo ukora firime: HPMC irashobora gukora firime iboneye, idafite ibara, yoroheje.
Amazi meza: Ashonga vuba mumazi akonje, ariko akora gel mumazi ashyushye.
Igenzura rya Viscosity: Ubukonje bwumuti wa HPMC burashobora kugenzurwa muguhindura ubunini bwacyo hamwe nuburemere bwa molekile.
Ubusembwa bwa chimique: Bumeze neza muburyo bwinshi kandi ntibwifata nibiyobyabwenge.
(4). Porogaramu ya farumasi
4.1 Kugenzura imyiteguro yo kurekura
HPMC ifite uruhare runini mugutegura-kurekura no kugenzura-kurekura. Irashobora gukora inzitizi ya gel, kugenzura igipimo cyo gusesa ibiyobyabwenge, kandi ikagera ku ntego yo kongera igihe cyo gukora.
Ibinini bigenzurwa-bisohora umunwa: Iyo bivanze nibiyobyabwenge, bikora matrix yo kurekura buhoro ibiyobyabwenge. Nka nkenerwa nyamukuru mubinini bimwe na bimwe bikomeza-kurekura, HPMC irashobora kugenda buhoro buhoro igakora geli igenzura irekurwa ryibiyobyabwenge.
Microspheres na microcapsules: Nka agent ikora firime cyangwa stabilisateur ihagarika, ikoreshwa mugukingira ibice byibiyobyabwenge no kugabanya umuvuduko wo kurekura.
4.2 Ibikoresho byo gutwikira
Nkibikoresho byo gutwikira, HPMC irashobora gutanga kurinda ibiyobyabwenge, kugenzura kurekura, kunoza isura, no guhisha impumuro mbi cyangwa uburyohe.
Kwinjiza enteric: HPMC ihujwe nizindi polymers kugirango ikore ibibyimba byinjira mu mutima birwanya umutobe wigifu, byemeza ko imiti irekurwa mu mara aho kuba mu gifu.
Ipitingi ya firime: Ipitingi ya firime ikoreshwa kubinini cyangwa granules kugirango utezimbere ituze no kumira ihumure.
4.3
Ibikoresho bihuza HPMC bituma bihuza neza mugutegura tablet. Irashobora kunoza compressible ya puderi nimbaraga za mashini za tableti.
Ibinini: Byakoreshejwe nka binder muri granulation itose kugirango umenye neza ko ifu ishobora guhindurwamo ibinini bikomeye kandi bimwe.
Imyiteguro ya Granular: HPMC irashobora kunoza uburinganire nimbaraga za granules no kugabanya igihe cyo gusenyuka.
4.4 Inkoko hamwe nuguhagarika abakozi
Nkibyimbye nibihagarika, HPMC irashobora kunoza ituze hamwe nuburinganire bwimyiteguro yamazi.
Amazi yo mu kanwa: Kunoza uburyohe no gutuza no gukumira imvura yibigize.
Porogaramu yibanze: Yifashishijwe nkibyimbye muri cream na geles kugirango itange ubwiza bukwiye no gukoraho.
4.5 Porogaramu y'amaso
HPMC ikoreshwa cyane mugutegura amaso, cyane cyane amarira yubukorikori hamwe na gele yubuvuzi.
Amosozi yubukorikori: Nka mavuta, atanga ingaruka nziza kandi itanga ibimenyetso byamaso yumye.
Ophthalmic gel: Yongerera igihe cyo gutura imiti hejuru ya ocular kandi ikanoza imikorere.
4.6
HPMC irashobora gukoreshwa mugukora capsules zikomoka ku bimera (HPMC capsules) nk'igisimbuza capsules ya gelatine, ibereye ibikomoka ku bimera cyangwa abarwayi bafite allergique y'ibikomoka ku nyamaswa.
Imboga zikomoka ku bimera: Tanga ibintu bisa na gelatine capsules kandi ntabwo bigira ingaruka kubibazo byimyitwarire yibikomoka ku nyamaswa.
(5). Ibyiza
Biocompatibilité: HPMC ntabwo ari uburozi kandi ntigutera uburakari, ibereye imiti itandukanye.
Imiti ihamye: Ntabwo ikora hamwe nibikoresho bya farumasi ikora kandi ikomeza ibikorwa byibiyobyabwenge.
Guhinduranya: Irashobora gukoreshwa mugusohora kugenzurwa, gutwikira, guhuza, kubyimba no guhagarikwa.
Ibidukikije byangiza ibidukikije: HPMC ikozwe muri selile isanzwe kandi irashobora kongerwa kandi ikabora.
6. Inzitizi n'ibiteganijwe
Nubwo HPMC ifite ibyiza byinshi mugutegura ibiyobyabwenge, hari n'ingorane zimwe na zimwe. Kurugero, imiterere yumubiri irashobora gukenera kunozwa kugirango ibiyobyabwenge bisohore imiti myinshi. Byongeye kandi, ubushakashatsi buzaza bushobora kwibanda ku kurushaho kunoza ikoreshwa rya HPMC muri sisitemu yo gutanga imiti ikora neza hifashishijwe uburyo bwa molekile ihindura cyangwa igahuza n’ibindi bikoresho kugirango yongere imikorere yayo.
Urwego rwa farumasi hydroxypropyl methylcellulose (HPMC) igira uruhare rudasubirwaho mubikorwa bya farumasi bigezweho kubera byinshi kandi bifite imiterere myiza ya fiziki. Kuva kugenzurwa kugenzurwa, gutwikira guhuza no kubyimba, urwego rwa porogaramu ya HPMC ni rugari kandi rwagutse. Hamwe niterambere ryikoranabuhanga no guteza imbere imiti mishya, HPMC izagira uruhare runini muri sisitemu yo gutanga ibiyobyabwenge.
Igihe cyo kohereza: Jun-14-2024