Isano iri hagati ya vickom ya HPMC nubushyuhe ningamba

HPMC (HydroxyPropyl Methylcellse) ni pharmasiotique isanzwe ikoreshwa mugukora imiti itandukanye, harimo ibinini, captsules, nibicuruzwa bya capthale. Kimwe mu bintu by'ingenzi bya HPMC ni virusi yayo, igira ingaruka kumitungo yibicuruzwa byanyuma. Iyi ngingo izashakisha isano iri hagati ya viccosi yubushyuhe bwa HPMC nubushyuhe kandi igaragaze ko hari ingamba zigomba gufatwa mugihe ukoresheje ibi byitwa.

Umubano hagati ya HPMC viccosity nubushyuhe

HPMC ni polymber polymer irimo gushonga mumazi hamwe nibindi bikoresho bya polar. Iyo HPMC ishonga mumazi, ikora igisubizo cya vinoti kubera uburemere bwimisozi miremire bwa polemer nurwego rwo hejuru rwa hydrophile. Ibyamamare bya HPMC bigira ingaruka kubintu byinshi, harimo kwibanda kuri polymer, ubushyuhe bwigisubizo, na PH ya solive.

Kimwe mu bintu by'ingenzi bireba viscosity igisubizo cya HPMC ni ubushyuhe. Viscosiya ibisubizo bya HPMC bigabanya ubushyuhe. Ibi ni ukubera ubushyuhe bwo hejuru, iminyururu ya polymer ihinduka amazi, bikaviramo ingabo nke zifite iminyururu ya polymer hamwe. Nkigisubizo, viscogity yumuco iragabanuka kandi amazi yigisubizo yiyongera.

Isano iri hagati yubushyuhe na HPMC irashobora gusobanurwa nikigereranyo cya Arrhenius. Ikigereranyo cya Arrhenius ni ikigereranyo cyimibare gisobanura isano iri hagati yibipimo byimiti nubushyuhe bwa sisitemu. Kubisubizo bya HPMC, ikigereranyo cya Arrnius gishobora gukoreshwa mugusobanura isano iri hagati yumuti wa stossity na sisitemu yubushyuhe.

Ikigereranyo cya Arrhenius cyatanzwe na:

k = ae ^ (- ea / ea / rt)

aho k ari igipimo gihoraho, a ni ikintu cyambere cyambere, ea ni imbaraga zikora, r ni gaze ihoraho, kandi t ni ubushyuhe bwa sisitemu. Ibyatsi bya HPMC Ibisubizo bya HPMC bifitanye isano nigipimo cyurugendo rwo gupfobya muri Matrix Polymer, kikaba kigengwa nihame rimwe nkigipimo cyibitekerezo bya shimi. Kubwibyo, ikigereranyo cya Arrhenius gishobora gukoreshwa mugusobanura isano iri hagati yumuti wa stosity na sisitemu yubushyuhe.

Ibintu kugirango umenye igihe ukoresheje HPMC

Iyo ukorana na HPMC, ingamba nyinshi zigomba gufatwa kugirango uhonde umutekano kandi neza. Iri genzura ririmo:

1. Koresha ibikoresho birinda

Ni ngombwa gukoresha ibikoresho byo gukingira nka gants, amaherezo ya lab mugihe ukoresha HPMC. Ni ukubera ko HPMC ishobora kurakaza uruhu n'amaso, kandi irashobora gutera ibibazo byubuhumekero iyo ihumeka. Kubwibyo, ni ngombwa gufata ingamba zo kugabanya ibyago byo guhura na polymers.

2. Bika HPMC neza

HPMC igomba kubikwa ahantu hakonje, kwumye kugirango wirinde kwinjiza ubushuhe mu kirere. Ni ukubera ko HPMC ni hygroscopique, bivuze ko ikurura ubushuhe kuva ahantu hakikije. Niba HPMC ikurura ubushuhe cyane, irashobora kugira ingaruka kuri viscosity numutungo wibicuruzwa byanyuma.

3. Witondere kwibanda n'ubushyuhe

Mugihe uterekeza na HPMC, menya neza ko witondera kwibanda no kwibanda ku gisubizo. Ni ukubera ko viscosiya ibisubizo bya HPMC igenwa nibi bintu. Niba kwibanda cyangwa ubushyuhe ari hejuru cyane cyangwa buke cyane, bizagira ingaruka kuri viscosiya hamwe nibicuruzwa byanyuma.

4. Koresha uburyo bwo gutunganya neza

Mugihe utunganya HPMC, ni ngombwa gukoresha uburyo bwo gutunganya neza kugirango ukemure neza kandi neza. Ibi birashobora kubamo gukoresha uburyo buke-bwo kuvanga kugirango wirinde kogosha polymer cyangwa gukumira, cyangwa gukoresha tekinike yumye kugirango ukureho ubushuhe burenze kubicuruzwa byanyuma.

5. Reba neza

Mugihe ukoresheje HPMC nkumushishozi, ni ngombwa kugenzura guhuza nabandi bababaye nibikoresho bifatika muri formulate. Ni ukubera ko HPMC ishobora gusabana nibindi bikoresho muri formulation, bigira ingaruka kumikorere no gutuza kubicuruzwa byanyuma. Kubwibyo, ni ngombwa gukora ubushakashatsi buhuza kugirango tumenye ibibazo byose byabishoboka mbere yo gukomeza forelation.

Mu gusoza

Ibyamamare bya HPMC Ibisubizo bya HPMC bigira ingaruka kubintu byinshi, harimo kwibanda, ubushyuhe, na PH. Ibyamamare bya HPMC Ibisubizo bya HPMC bigabanuka hamwe n'ubushyuhe kubera kwiyongera k'umunyururu wa polymer. Iyo ukorana na HPMC, ni ngombwa gufata ingamba zikwiye kugirango Polymer yizewe kandi inoze. Izi ngamba zirimo gukoresha ibikoresho byo gukingira, kubika neza HPMC, witondera kwibanda no kwibandaho, ukoresheje uburyo bwo gutunganya, no kugenzura guhuza nibindi bikoresho muri formula. Mugufata izo ngamba, HPMC irashobora gukoreshwa nkicyiciro cyiza muburyo butandukanye bwa farumasi.