Isano iri hagati yubukonje bwa HPMC nubushyuhe no kwirinda

HPMC (hydroxypropyl methylcellulose) ni imiti ikoreshwa cyane mu gukoresha imiti ikoreshwa mu gukora imiti itandukanye ya farumasi, harimo ibinini, capsules, n’ibicuruzwa by’amaso. Imwe mu miterere yingenzi ya HPMC nubukonje bwayo, bigira ingaruka kumiterere yibicuruzwa byanyuma. Iyi ngingo izasesengura isano iri hagati yubukonje bwa HPMC nubushyuhe kandi igaragaze ingamba zimwe na zimwe zigomba gufatwa mugihe ukoresheje iyi nyungu.

Isano iri hagati yubukonje bwa HPMC nubushyuhe

HPMC ni hydrophilique polymer ikemuka mumazi hamwe nandi mashanyarazi. Iyo HPMC imaze gushonga mumazi, ikora igisubizo kiboneye bitewe nuburemere bwa polymer burenze urugero hamwe na hydrophilique. Ubukonje bwibisubizo bya HPMC bugira ingaruka kubintu byinshi, harimo kwibanda kuri polymer, ubushyuhe bwumuti, hamwe na pH yumuti.

Kimwe mu bintu by'ingenzi bigira ingaruka ku bwiza bw'igisubizo cya HPMC ni ubushyuhe. Ubukonje bwibisubizo bya HPMC buragabanuka hamwe nubushyuhe bwiyongera. Ni ukubera ko ku bushyuhe bwo hejuru, iminyururu ya polymer iba amazi menshi, bigatuma imbaraga nke za intermolecular zifata iminyururu ya polymer hamwe. Nkigisubizo, ubwiza bwigisubizo buragabanuka kandi amazi yumuti ariyongera.

Isano iri hagati yubushyuhe hamwe nubwiza bwa HPMC irashobora gusobanurwa nuburinganire bwa Arrhenius. Ikigereranyo cya Arrhenius nikigereranyo cyimibare isobanura isano iri hagati yikigereranyo cyimiti nubushyuhe bwa sisitemu. Kubisubizo bya HPMC, ikigereranyo cya Arrhenius kirashobora gukoreshwa mugusobanura isano iri hagati yubushuhe bwibisubizo hamwe nubushyuhe bwa sisitemu.

Ikigereranyo cya Arrhenius gitangwa na:

k = Ae ^ (- Ea / RT)

aho k ni igipimo gihoraho, A nikintu kibanziriza kwerekana, Ea nimbaraga zo gukora, R ni gaze ihoraho, na T nubushyuhe bwa sisitemu. Ubukonje bwibisubizo bya HPMC bujyanye nigipimo cy umuvuduko wa solvent binyuze muri polymer matrix, igenzurwa nihame rimwe nigipimo cyibisubizo byimiti. Kubwibyo, ikigereranyo cya Arrhenius kirashobora gukoreshwa mugusobanura isano iri hagati yubukonje bwibisubizo hamwe nubushyuhe bwa sisitemu.

Ibintu ugomba kwitondera mugihe ukoresha HPMC

Mugihe ukorana na HPMC, hagomba gufatwa ingamba nyinshi kugirango umutekano wa polymer ukorwe neza kandi neza. Muri ubwo buryo bwo kwirinda harimo:

1. Koresha ibikoresho birinda

Ni ngombwa gukoresha ibikoresho birinda nk'uturindantoki, indorerwamo z'amaso, n'amakoti ya laboratoire igihe ukoresha HPMC. Ni ukubera ko HPMC ishobora kurakaza uruhu n'amaso, kandi irashobora gutera ibibazo byubuhumekero iyo ihumeka. Kubwibyo, ni ngombwa gufata ingamba zo kugabanya ingaruka zo guhura na polymers.

2. Bika HPMC neza

HPMC igomba kubikwa ahantu hakonje, humye kugirango hirindwe kwinjiza amazi mu kirere. Ni ukubera ko HPMC ari hygroscopique, bivuze ko ikuramo ubuhehere buturuka ku bidukikije. Niba HPMC ikurura ubuhehere bwinshi, irashobora kugira ingaruka kumiterere yibicuruzwa byanyuma.

3. Witondere kwibanda hamwe n'ubushyuhe

Mugihe utegura hamwe na HPMC, menya neza ko witondera kwibanda hamwe nubushyuhe bwigisubizo. Ni ukubera ko ubwiza bwibisubizo bya HPMC bugenwa ahanini nizi mpamvu. Niba kwibumbira hamwe cyangwa ubushyuhe buri hejuru cyane cyangwa hasi cyane, bizagira ingaruka kumyumvire nibiranga ibicuruzwa byanyuma.

4. Koresha uburyo bukwiye bwo gutunganya

Iyo utunganya HPMC, ni ngombwa gukoresha uburyo bukwiye bwo gutunganya kugirango umenye neza kandi neza imikorere ya polymer. Ibi birashobora kubamo gukoresha uburyo buke bwo kuvanga uburyo bwo kwirinda gukata polymer cyangwa gusenyuka, cyangwa gukoresha uburyo bukama bwumye kugirango ukureho ubuhehere burenze kubicuruzwa byanyuma.

5. Reba guhuza

Iyo ukoresheje HPMC nkibintu byoroshye, ni ngombwa kugenzura guhuza nibindi bicuruzwa hamwe nibikoresho bikora muburyo bwo gukora. Ni ukubera ko HPMC ishobora gukorana nibindi bikoresho muburyo bwo gukora, bigira ingaruka kumikorere no gutuza kwibicuruzwa byanyuma. Niyo mpamvu, ni ngombwa gukora ubushakashatsi bujyanye no kumenya ibibazo byose bishoboka mbere yo gukomeza kubikora.

mu gusoza

Ubukonje bwibisubizo bya HPMC bugira ingaruka kubintu byinshi, harimo kwibanda, ubushyuhe, na pH. Ubukonje bwibisubizo bya HPMC buragabanuka hamwe nubushyuhe bwiyongera bitewe nubwiyongere bwiminyururu ya polymer. Iyo ukorana na HPMC, ni ngombwa gufata ingamba zikwiye kugirango umutekano wa polimeri ukorwe neza kandi neza. Muri ubwo buryo bwo kwirinda harimo gukoresha ibikoresho birinda, kubika neza HPMC, kwitondera kwibanda hamwe nubushyuhe, gukoresha uburyo bukwiye bwo gutunganya, no kugenzura guhuza nibindi bikoresho biri muri formula. Ufashe ingamba zo kwirinda, HPMC irashobora gukoreshwa nkigikoresho cyiza muburyo butandukanye bwa farumasi.