HPMC ni polymer ya kimwe cya kabiri ikomoka kuri selile. Bitewe nubwiza buhebuje, butuza kandi bukora firime, bukoreshwa cyane mubuvuzi, ibiryo, amavuta yo kwisiga nizindi nganda. Kwiga imyitwarire ya viscosity ningirakamaro kugirango uhindure imikorere yayo mubikorwa bitandukanye.
1. Gupima ubunini:
Viscometero Ihinduranya: Visometero izenguruka ipima urumuri rusabwa kugirango ruzunguruke ruzunguruka ku muvuduko uhoraho iyo rwinjijwe mu cyitegererezo. Muguhindura geometrie n'umuvuduko ukabije wa spindle, ubwiza bwibiciro bitandukanye byogosha birashobora kugenwa. Ubu buryo bushoboza kuranga HPMC viscosity mubihe bitandukanye.
Capillary Viscometer: Capclary viscometer ipima urujya n'uruza rw'amazi binyuze mumiyoboro ya capillary bitewe nuburemere cyangwa umuvuduko. Igisubizo cya HPMC gihatirwa binyuze muri capillary tube kandi viscosity ibarwa hashingiwe ku kigero cyo kugabanuka no kugabanuka k'umuvuduko. Ubu buryo burashobora gukoreshwa mukwiga ubukonje bwa HPMC kurwego rwo hasi.
Ibipimo bya reologiya:
Dynamic Shear Rheometry (DSR): DSR ipima igisubizo cyibikoresho kugirango ihindurwe. Ingero za HPMC zatewe no guhinda umushyitsi no gupimwa. Imyitwarire ya viscoelastic yibisubizo bya HPMC irashobora kurangwa no gusesengura ibintu bigoye cyane (η *) kimwe nububiko bwo kubika (G ') hamwe nuburyo bwo gutakaza (G ”).
Ibizamini bya creep no kugarura: Ibi bizamini birimo gukurikiza urugero rwa HPMC kugirango uhore uhangayitse cyangwa uhangayike mugihe kinini (icyiciro cya creep) hanyuma ugakurikirana gukira nyuma yo guhangayika cyangwa guhangayika. Imyitwarire ya creep no kugarura itanga ubushishozi kumiterere ya viscoelastic ya HPMC, harimo no guhindura no kugarura ubushobozi.
3. Kwibanda hamwe nubushakashatsi bushingiye ku bushyuhe:
Gusikana Kwibanda: Ibipimo bya Viscosity bikorerwa murwego rwinshi rwa HPMC kugirango bige isano iri hagati yubukonje nubushakashatsi bwa polymer. Ibi bifasha gusobanukirwa nububyibushye bwa polymer nimyitwarire yayo ishingiye kubitekerezo.
Gusikana ubushyuhe: Ibipimo bya Viscosity bikorwa mubushyuhe butandukanye kugirango bige ku ngaruka z'ubushyuhe kuri HPMC. Gusobanukirwa nubushyuhe biterwa ningirakamaro kubisabwa aho HPMCs ihinduka ryubushyuhe, nkibikoresho bya farumasi.
4. Isesengura ry'uburemere bwa molekuline:
Ingano yo Kwirinda Chromatografiya (SEC): SEC itandukanya molekile ya polymer ukurikije ubunini bwayo mubisubizo. Mugusesengura umwirondoro wa elution, kugabanya uburemere bwa molekuline ya sample ya HPMC irashobora kugenwa. Gusobanukirwa isano iri hagati yuburemere bwa molekuline nubukonje ningirakamaro mu guhanura imyitwarire ya rheologiya ya HPMC.
5. Kwerekana no kwigana:
Moderi yuburyo bwiza: Moderi zitandukanye zuburyo bwiza, nka moderi ya Carreau-Yasuda, icyitegererezo cyumusaraba cyangwa amategeko agenga ingufu, irashobora gukoreshwa mugusobanura imyitwarire yubukonje bwa HPMC mubihe bitandukanye. Izi moderi zihuza ibipimo nkigipimo cyogosha, kwibanda, hamwe nuburemere bwa molekuline kugirango tumenye neza ububobere.
Ibigereranyo byo Kubara: Ibigereranyo bya Fluid Dynamics (CFD) bigereranya ubushishozi kumyitwarire yimyitwarire ya HPMC muri geometrike igoye. Mugukemura muburyo bwo kugereranya ibiyobora byamazi, ibigereranyo bya CFD birashobora guhanura ikwirakwizwa ryubwiza nuburyo bwo gutembera mubihe bitandukanye.
6. Muburyo no mubushakashatsi bwa vitro:
Ibipimo-by-in-tekinike: Muri-tekinike ikubiyemo kwiga igihe-nyacyo cyo guhinduka mubidukikije cyangwa porogaramu. Kurugero, muburyo bwa farumasi, mubipimo bishobora kugenzura ihinduka ryijimye mugihe cyo gusenyuka kwa tablet cyangwa gel ya progaramu ya gel.
Mu gupima vitro: Mu gupima vitro bigereranya imiterere ya physiologique kugirango isuzume imyitwarire yubukonje bwimikorere ya HPMC igenewe ubuyobozi bwo munwa, ocular, cyangwa ubuyobozi bwibanze. Ibi bizamini bitanga amakuru yingirakamaro kumikorere no gutezimbere kwimiterere yimiterere yibinyabuzima bijyanye.
7.Ikoranabuhanga ryateye imbere:
Microrheology: Tekinike ya Microrheologiya, nkumucyo ukwirakwiza urumuri (DLS) cyangwa uduce duto dukurikirana microrheology (PTM), yemerera kugenzura imiterere ya viscoelastic yibintu byamazi bigoye kurwego rwa microscopique. Ubu buhanga bushobora gutanga ubushishozi kumyitwarire ya HPMC kurwego rwa molekile, ikuzuza ibipimo bya macroscopique rheologiya.
Nuclear Magnetic Resonance (NMR) Spectroscopy: NMR spectroscopy irashobora gukoreshwa mukwiga imbaraga za molekile n'imikoranire ya HPMC mugisubizo. Mugukurikirana ihindagurika ryimiti nibihe byo kwidagadura, NMR itanga amakuru yingirakamaro kumihindagurikire ya HPMC hamwe n’imikoranire ya polymer-solvent igira ingaruka ku bwiza.
Kwiga imyitwarire yubusa ya HPMC bisaba uburyo butandukanye, harimo tekinike yubushakashatsi, kwerekana imiterere, hamwe nuburyo bunoze bwo gusesengura. Ukoresheje guhuza viscometrie, rheometrie, isesengura rya molekile, kwerekana imiterere, hamwe nubuhanga buhanitse, abashakashatsi barashobora gusobanukirwa byimazeyo imiterere yimiterere ya HPMC kandi bagahindura imikorere yayo mubikorwa bitandukanye.
Igihe cyoherejwe: Gashyantare-29-2024