Pharmaceutical Grade Hydroxypropyl Methylcellulose (HPMC) ni imiti ikoreshwa cyane mu miti, ikoreshwa cyane mu nganda zimiti. Nibice bya sintetike, inert, amazi ya elegitoronike ya selile ya ether, ihindurwa muburyo bwa chimique kuva selile. HPMC ifite firime nziza yo gukora, kubyimba, gufatira hamwe, guhagarika no kurwanya keke, bityo ifite agaciro gakomeye mugukoresha imiti.
1. Ibintu shingiro bya HPMC
HPMC ikorwa mugusimbuza hydroxyl igice cya selile hamwe na hydroxypropyl hamwe nitsinda ryimikorere. Imiterere ya molekile yayo irimo ibintu bibiri, hydroxypropyl na methyl, bityo ikaba yitwa hydroxypropyl methylcellulose. HPMC ifite imbaraga zo gukemura neza mumazi, kandi nyuma yo kuyasesa, ikora igisubizo kibonerana. Mugihe kwibanda kwiyongera, ubwiza nabwo buriyongera. Byongeye kandi, HPMC ifite ubushyuhe bwiza nubushyuhe bwimiti, kandi ifite kwihanganira aside, alkali numuti wumunyu.
2. Gukoresha HPMC muri farumasi
HPMC ikoreshwa cyane mu nganda zimiti, cyane cyane mubice bikurikira:
a. Igikoresho cya tableti
HPMC, nk'ibikoresho byo gutwikira ibinini, irashobora gupfukirana uburyohe bubi bw'ibiyobyabwenge, kunoza isura y'ibiyobyabwenge, kandi bifite ingaruka zidashobora kwangiza no kurwanya okiside. Byongeye kandi, irashobora kongera igihe cyo kurekura ibiyobyabwenge mumitsi yigifu, bityo bikagera ku ngaruka zihoraho cyangwa zigenzurwa.
b. Inkoko hamwe na binders
Mugihe utegura guhagarikwa, emulisiyo, capsules nindi myiteguro, HPMC, nkibibyimbye kandi bihuza, irashobora kunoza ihame nuburinganire bwimyiteguro. Muri icyo gihe, HPMC irashobora kandi kongera imbaraga nimbaraga za tableti kugirango ibiyobyabwenge bitavunika byoroshye mugihe cyo gukora no gutwara.
c. Kugenzura no gukomeza-kurekura imyiteguro
HPMC ikoreshwa kenshi mugutegura-kurekura no gukomeza-kurekura kuko igipimo cya gel ikora gishobora kubuza amazi kwinjira muri kiriya kibaho, kugirango igipimo cyo gusohora no kurekura ibiyobyabwenge bigenzurwe neza. Muguhindura ibishishwa hamwe na dosiye ya HPMC, igipimo cyo kurekura imiti gishobora kugenzurwa neza, igihe cyibiyobyabwenge gishobora kuramba, kandi imiti ishobora kugabanuka.
d. Nkuzuza
Mu myiteguro ya capsule, HPMC irashobora gukoreshwa nkuzuza kuzuza capsules yuzuye. Ugereranije na capsules ya gelatine gakondo, capsules ya HPMC ifite ibyiza byo gukomoka ku bimera kandi bitarimo ibikomoka ku nyamaswa, bityo bikwiriye ibikomoka ku bimera n’abarwayi bafite kirazira z’idini.
3. Umutekano wa HPMC
Nkibikoresho bya farumasi, HPMC ifite biocompatibilité nziza numutekano. Ntabwo yangirika n'imisemburo igogora mumubiri wumuntu kandi isohoka cyane mumubiri ikoresheje amara, ntabwo rero igira uruhare mubikorwa byo guhinduranya ibiyobyabwenge kandi ntibitanga ingaruka zuburozi. HPMC yakoreshejwe cyane mu myiteguro itandukanye yo mu kanwa, ku ngingo no mu gutera inshinge kandi izwi na pharmacopoeias ku isi.
4. Icyizere cy'isoko
Hamwe niterambere ryiterambere ryinganda zimiti, ibisabwa kumiterere yumuti numutekano nabyo biriyongera. Bitewe nimiterere yihariye yumubiri nubumashini numutekano mwiza, HPMC ifite ibyifuzo byinshi byo gutegura imiti mishya. By'umwihariko mu rwego rwo kugenzura-kurekura no gutegurwa kurekurwa, imiti y’ibinyabuzima n’imiti ku baturage badasanzwe (nk'ibikomoka ku bimera), icyifuzo cya HPMC kizakomeza kwiyongera.
Nkimiti myinshi ikora imiti, hydroxypropyl methylcellulose yo mu rwego rwa farumasi yagize uruhare runini mu nganda zimiti kandi izakomeza gukoreshwa cyane no guteza imbere ejo hazaza.
Igihe cyo kohereza: Kanama-06-2024