HPMC ni synthique cyangwa nibisanzwe?

Hydroxypropylmethylcellulose (HPMC) ni ibintu byinshi kandi bitandukanye hamwe nibisabwa mubikorwa bitandukanye. Kugira ngo wumve ishingiro ryayo, umuntu agomba gucengera ibiyigize, inzira zikora, ninkomoko.

Ibigize HPMC:
HPMC ni polymer ya kimwe cya kabiri ikomoka kuri selile, polyisikaride isanzwe iboneka murukuta rw'utugingo ngengabuzima. Inkomoko nyamukuru ya selile ni ibiti byimbuto cyangwa fibre. Synthesis ya HPMC ikubiyemo guhindura selile ikoresheje urukurikirane rw'imiti kugirango ibe inkomoko ya selile.

Ibice bigize sintetike yumusaruro wa HPMC:
Igikorwa cyo gushimangira:

Umusaruro wa HPMC urimo etherifike ya selile hamwe na okiside ya propylene na methyl chloride.
Muri iki gikorwa, amatsinda ya hydroxypropyl na methyl yinjizwa mumugongo wa selile, akora HPMC.

Guhindura imiti:

Guhindura imiti byatangijwe mugihe cya synthesis bivamo HPMC ishyirwa mubice kimwe cya kabiri.
Impamyabumenyi yo gusimbuza (DS) bivuga impuzandengo ya hydroxypropyl na methyl matsinda kuri glucose igice cyumunyururu wa selile. Agaciro DS karashobora guhinduka mugihe cyo gukora kugirango ubone HPMC nibintu byihariye.

Umusaruro w'inganda:

HPMC ikorwa mu nganda ku rugero runini n’amasosiyete menshi akoresha imiti igenzura.
Igikorwa cyo gukora kirimo ibintu byuzuye kugirango ugere kubintu byifuzwa nibikorwa byanyuma.

Inkomoko karemano ya HPMC:
Cellulose nkisoko karemano:

Cellulose nibikoresho byibanze bya HPMC kandi ni byinshi muri kamere.
Ibimera, cyane cyane ibiti nipamba, ni isoko ya selile. Gukuramo selile muri aya masoko karemano bitangiza inzira yo gukora HPMC.

Ibinyabuzima bigabanuka:

HPMC irashobora kubora, umutungo wibintu byinshi.
Kubaho kwa selile karemano muri HPMC bigira uruhare mubintu byayo bishobora kwangirika, bigatuma ibidukikije byangiza ibidukikije mubikorwa bimwe na bimwe.

Porogaramu ya HPMC:
ibiyobyabwenge:

HPMC ikoreshwa cyane mubikorwa bya farumasi nkibikoresho byo gutwikira, guhambira hamwe na matrices irekura-irekura muburyo bwa tablet. Biocompatibilité hamwe nibisohoka bigenzurwa bituma ihitamo bwa mbere sisitemu yo gutanga ibiyobyabwenge.

Inganda zubaka:

Mu bwubatsi, HPMC ikoreshwa nkibikoresho bigumana amazi, kubyimbye, no gushyiraho igihe cyagenwe mubikoresho bishingiye kuri sima. Uruhare rwarwo mugutezimbere imikorere no gufatira minisiteri na plasta ni ngombwa.

inganda z'ibiribwa:

HPMC ikoreshwa nkibintu byongera umubyimba mu nganda zibiribwa.
Bikunze gukoreshwa mubicuruzwa byibiribwa nka sosi, isupu nibicuruzwa bitetse.

kwisiga:

Mu kwisiga, HPMC iboneka mubicuruzwa bitandukanye birimo amavuta, amavuta yo kwisiga, hamwe na geles, bikora nkibibyimbye, stabilisateur, na emulisiferi.

Gusaba inganda:

HPMC ihindagurika igera no mubikorwa bitandukanye byinganda, harimo gushushanya amarangi, ibifata hamwe no gutunganya imyenda.

Imiterere igenga:
Imiterere ya GRAS:

Muri Reta zunzubumwe za Amerika, HPMC isanzwe izwi nkumutekano (GRAS) kubisabwa bimwe mubiribwa nubuyobozi bwa Amerika bushinzwe ibiribwa nibiyobyabwenge (FDA).

Ibipimo byibiyobyabwenge:

HPMC ikoreshwa mubicuruzwa bya farumasi igomba kubahiriza ibipimo bya farumasi nka Pharmacopeia yo muri Amerika (USP) na Pharmacopoeia yu Burayi (Ph. Eur.).

mu gusoza:
Muri make, hydroxypropyl methylcellulose (HPMC) ni polymer-sintetike ya polymer ikomoka kuri selile naturel binyuze muburyo bwo guhindura imiti. Nubwo yagize ihinduka rikomeye ryubukorikori, inkomoko yabyo iri mumitungo kamere nkibiti byimbaho ​​na pamba. Imiterere yihariye ya HPMC ituma igizwe ningirakamaro ikoreshwa cyane muri farumasi, ubwubatsi, ibiryo, amavuta yo kwisiga ninganda zitandukanye. Ihuriro rya selile naturelose hamwe noguhindura synthique bigira uruhare muburyo butandukanye, biodegradabilite no kwemerwa byemewe mubice bitandukanye.