HPMC ni hydrogel?

Hydroxypropyl methylcellulose (HPMC) ni polymer itandukanye ikoreshwa mu nganda zitandukanye kubera imiterere yihariye. Mugihe ishobora gukoreshwa mugukora hydrogels mubihe bimwe na bimwe, ntabwo isanzwe ari hydrogel ubwayo.

1. Intangiriro kuri HPMC:

Hydroxypropyl methylcellulose (HPMC) ni polymer igice cya sintetike ikomoka kuri selile, polymer karemano iboneka murukuta rw'ibimera. Ihinduranya mukuvura selile hamwe na alkali hanyuma ikayitwara hamwe na oxyde ya propylene na methyl chloride. Polimeri yavuyemo yerekana ibintu bitandukanye bigira agaciro mubikorwa bitandukanye, harimo imiti, ibiryo, amavuta yo kwisiga, nubwubatsi.

2. Ibyiza bya HPMC:

HPMC ifite ibintu byinshi byiza:

a. Amazi meza:

HPMC irashonga mumazi, ikora ibisubizo bifatika. Uyu mutungo ufite akamaro kanini mubuvuzi, aho ushobora gukoreshwa muguhagarika, emulisiyo, hamwe nibiyobyabwenge-bigenzurwa.

b. Ubushobozi bwo Gukora Filime:

HPMC irashobora gukora firime zoroshye kandi zibonerana mugihe zashizwe mubisubizo byamazi. Izi firime zisanga porogaramu zifata ibinini, capsules, na firime zo munwa.

c. Guhindura imvugo:

HPMC ikora nkibibyimbye na rheologiya ihindura ibisubizo byamazi. Ubukonje bwacyo burashobora guhuzwa no guhindura ibintu nkuburemere bwa molekile hamwe nintera yo gusimburwa.

d. Biocompatibilité:

HPMC ni biocompatable kandi idafite uburozi, bigatuma ikoreshwa mu miti, imiti yo kwisiga, n'ibiribwa.

3. Porogaramu ya HPMC:

HPMC isanga porogaramu zikoreshwa mu nganda zitandukanye:

a. Imiti:

Mu miti ya farumasi, HPMC ikoreshwa nka binder, disintegrant, agent-coating firime, hamwe na matrix irekura-yahoze. Itezimbere ubudakemwa bwa tablet, igenzura ibiyobyabwenge bisohora, kandi ikanoza abarwayi.

b. Inganda zikora ibiribwa:

Mu nganda zibiribwa, HPMC ikoreshwa nkibyimbye, emulisiferi, stabilisateur, hamwe na gelling agent. Itanga umusanzu muburyo bwiza, ubwiza, no gutuza mubiribwa nkibisosi, imyambarire, hamwe nubutayu.

c. Amavuta yo kwisiga:

HPMC ikoreshwa mumavuta yo kwisiga hamwe nibicuruzwa byumuntu ku giti cye nkibibyibushye, bihagarika, firime yahoze, na emulifier. Itanga imiterere yamagambo ya cream, amavuta yo kwisiga, hamwe na geles mugihe byongera imbaraga zabo hamwe nibiranga amarangamutima.

d. Ubwubatsi:

Mu nganda zubaka, HPMC ikoreshwa mubikoresho bya sima nkibikoresho byo gufata amazi, kongera imbaraga, hamwe nubushakashatsi. Itezimbere imiterere ya minisiteri na plaster, nko gufatana, guhuriza hamwe, no kurwanya sag.

4. Imiterere ya Hydrogel hamwe na HPMC:

Mugihe HPMC ubwayo atari hydrogel, irashobora kugira uruhare mugushinga hydrogel mugihe gikwiye. Hydrogel ni urusobe rw'iminyururu ya polymer ishoboye gukurura no kugumana amazi menshi. Ishirwaho rya hydrogels ya HPMC mubisanzwe bikubiyemo guhuza iminyururu ya polymer kugirango habeho urusobe rwibice bitatu rushobora gukuramo amazi.

a. Abakozi bahuza:

Ibikoresho byuzuzanya nka glutaraldehyde, genipine, cyangwa uburyo bwumubiri nka cycle-thaw cycle birashobora gukoreshwa kugirango uhuze iminyururu ya HPMC. Uku guhuza ibisubizo mugushiraho umuyoboro wa hydrogel muri matrike ya HPMC.

b. Imyitwarire yo kubyimba:

Imiterere ya hydrogel ya HPMC irashobora guhuzwa no guhindura ibintu nkurwego rwo gusimbuza, uburemere bwa molekile, hamwe nubucucike. Urwego rwo hejuru rwo gusimbuza hamwe nuburemere bwa molekuline muri rusange biganisha ku kongera ubushobozi bwa hydrogel.

c. Porogaramu ya Hydrogels ya HPMC:

HPGC hydrogels isanga porogaramu mugutanga ibiyobyabwenge, gukira ibikomere, gukora ingirabuzimafatizo, hamwe no guhuza amakuru. Ibinyabuzima byabo bihuza, imiterere ihindagurika, hamwe nubushobozi bwo kugumana amazi bituma bikenerwa muburyo butandukanye bwo gukoresha imiti.

HPMC ni polymer itandukanye ifite porogaramu zitandukanye murwego rwa farumasi, ibiryo, amavuta yo kwisiga, ninganda zubaka. Nubwo atari hydrogel isanzwe, irashobora kugira uruhare mu gushinga hydrogel binyuze mu guhuza iminyururu ya polymer. Hydrogels ya HPMC ivamo yerekana ibintu nko kwinjiza amazi no kuyigumana, bigatuma bifite agaciro mubikorwa bya biomedical medicine. Mugihe ubushakashatsi bukomeje gushakisha uburyo bushya bwo gukoresha no gukoresha HPMC, akamaro kayo mu nganda zitandukanye biteganijwe ko kazaguka.