Hydroxypropylmethylcellulose (HPMC) ni uruganda rutandukanye rukoreshwa mu nganda zitandukanye zirimo imiti, ibiryo, ubwubatsi no kwisiga. Gusobanukirwa ibiyigize, imiterere, imiterere nibisabwa bisaba ubushakashatsi bwimbitse bwibigize imiti hamwe na synthesis.
imiterere n'imiterere
Umugongo wa Cellulose: HPMC ikomoka kuri selile, polymer karemano iboneka murukuta rwibimera. Cellulose igizwe n'iminyururu miremire ya glucose ihujwe hamwe na β-1,4 glycosidic.
Methylation: Methylcellulose ni intangiriro ya HPMC kandi ikorwa no kuvura selile hamwe na alkali na chloride ya methyl. Inzira ikubiyemo gusimbuza hydroxyl (-OH) kumatsinda yumugongo wa selile hamwe na methyl (-CH3).
Hydroxypropylation: Nyuma ya methylation, hydroxypropylation ibaho. Muri iyi ntambwe, okiside ya propylene ikorana na selile ya methylated, ikinjiza hydroxypropyl (-OCH2CHOHCH3) mumatsinda ya selile.
Impamyabumenyi yo gusimburana (DS): Urwego rwo gusimbuza bivuga umubare mpuzandengo w'amatsinda ya hydroxypropyl na methyl kuri buri glucose ya glucose mumurongo wa selile. Iyi parameter igira ingaruka kumiterere ya HPMC, harimo gukemuka kwayo, ubukonje, nimyitwarire yubushyuhe.
synthesis
Kuvura alkaline: Fibre ya selulose yabanje kuvurwa hakoreshejwe umuti wa alkaline, ubusanzwe hydroxide ya sodium (NaOH), kugirango ucike imigozi ya hydrogène intermolecular no kongera ubushobozi bwamatsinda ya hydroxyl ya selile.
Methylation: Cellulose ivurwa na alkali ikorwa na methyl chloride (CH3Cl) mugihe cyagenzuwe, bikavamo gusimbuza amatsinda ya hydroxyl nitsinda rya methyl.
Hydroxypropylation: Methylated selulose irongera ikora hamwe na oxyde ya propylene (C3H6O) imbere ya catalizator nka hydroxide ya sodium. Iyi reaction itangiza amatsinda ya hydroxypropyl mumugongo wa selile.
Kutabogama no kwezwa: Kutabogama kuvanga reaction kugirango ukureho ishingiro rirenze. Ibicuruzwa byabonetse bigenda byogusukura nko kuyungurura, gukaraba, no gukama kugirango ubone ibicuruzwa bya nyuma bya HPMC.
biranga
Gukemura: HPMC irashonga mumazi kandi ikora igisubizo gisobanutse neza. Gukemura biterwa nimpamvu nkurwego rwo gusimburwa, uburemere bwa molekile, nubushyuhe.
Viscosity: HPMC ibisubizo byerekana imyitwarire ya pseudoplastique, bivuze ko ububobere bwabo bugabanuka hamwe no kongera umuvuduko wogosha. Viscosity irashobora kugenzurwa muguhindura ibipimo nka DS, uburemere bwa molekile hamwe nibitekerezo.
Imiterere ya firime: HPMC ikora firime zoroshye kandi zibonerana mugihe zashizwe mubisubizo byamazi. Izi firime zisanga porogaramu mubitambaro, gupakira hamwe na farumasi.
Ubushyuhe bwa Thermal: HPMC ihagaze neza mubushuhe runaka, hejuru yangirika. Ubushyuhe bwumuriro buterwa nibintu nka DS, ibirimo ubuhehere, hamwe ninyongeramusaruro.
Ahantu ho gusaba
Imiti ya farumasi: HPMC ikoreshwa cyane mubikorwa bya farumasi nkibibyimbye, binders, imashini ikora firime hamwe na matrices irekura. Itezimbere ibinini bisenyuka, guseswa na bioavailability.
Ibiribwa: Mu nganda zibiribwa, HPMC ikoreshwa nkibibyimbye, stabilisateur, emulisiferi hamwe nuwuzuza ibicuruzwa nka sosi, imyambarire, ibicuruzwa bitetse nibikomoka ku mata.
Ubwubatsi: HPMC yongewe kumasima ashingiye kuri sima, stucco hamwe nudukaratasi twa tile kugirango tunoze imikorere, gufata amazi no gufatira hamwe. Itezimbere imikorere yibi bikoresho byubaka mubihe bitandukanye.
Amavuta yo kwisiga: HPMC ikoreshwa nkibyimbye, emulisiferi na stabilisateur muburyo bwo kwisiga nka cream, amavuta yo kwisiga hamwe na geles. Itanga imvugo yifuzwa kandi ikongera ibicuruzwa bihamye.
Hydroxypropyl methylcellulose (HPMC) nuruvange rwimikorere myinshi ikomatanyirizwa muri selile ikoresheje methylation hamwe na hydroxypropylation. Imiterere yimiti, imiterere nuburyo bukoreshwa bituma iba ingirakamaro mu nganda zitandukanye nka farumasi, ibiryo, ubwubatsi n’amavuta yo kwisiga. Ubundi bushakashatsi no guteza imbere tekinoroji ya HPMC ikomeje kwagura ibikorwa byayo no kunoza imikorere yayo muburyo butandukanye.
Igihe cyo kohereza: Gashyantare-20-2024