Hydroxypropyl methylcellulose HPMC?

Hydroxypropyl methylcellulose HPMC ni selile ya ionic selulose ivanze ether muri ethers zitandukanye zivanze hamwe na ionic methylcarboxymethylcellulose. Ntabwo ikora hamwe nicyuma kiremereye. Itandukaniro riri mubiri muri hydroxypropyl methylcellulose, hydroxypropyl methylcellulose, hamwe na hydroxypropyl igereranyo cyibirimo hamwe nubwiza bwa gene yubusa ya ogisijeni bifite ubwoko butandukanye rwose mubikorwa. Kurugero, ubwoko bufite vitamine nyinshi hamwe na hydroxypropyl nkeya bifite imikorere itandukanye. Hafi ya methylcellulose hamwe nubwoko buke bwibirimo. Ugereranije nubwoko bufite hydroxypropyl yo hejuru, imikorere yayo yegereye iya hydroxypropyl methylcellulose yakozwe. Nubwo, nubwo buri bwoko burimo umubare muto wa hydroxypropyl cyangwa itsinda rito rya mikorerexy, hariho itandukaniro rikomeye mugukemuka mumashanyarazi cyangwa ubushyuhe bwa flocculation mubisubizo byamazi.

1. Gukemura hydroxypropyl methylcellulose

Gukemura hydroxypropyl methylcellulose mumazi Hydroxypropyl methylcellulose mubyukuri ni oxyde ya propylene (methylhydroxypropyl impeta) yahinduwe methylcellulose, bityo iracyafite imitungo imwe na methylcellulose Ifite imiterere isa no gushonga mumazi akonje ariko idashonga mumazi ashyushye. Nyamara, ubushyuhe bwa hydroxypropyl bwahinduwe mumazi ashyushye buri hejuru cyane ya methylcellulose. Kurugero, 2% hydroxypropyl methylcellulose yumuti wamazi hamwe nibice byitsinda rya DS = 0,73 hamwe nitsinda rya hydroxypropyl MS = 0.46 ifite viscosity ya 500mpa kuri 20 ° C. Ubushyuhe bwa gel bwibicuruzwa S bigera kuri 100 ° C, mugihe ibya methylcellulose mubushyuhe bumwe ni nka 55 ° C. Kubijyanye no gukomera kwayo mumazi, nayo yaratejwe imbere cyane. Kurugero, nyuma ya hydroxypropyl methylcellulose yajanjaguwe (imiterere yibice ni 0.2 ~ 0.5mm, ubwiza bwamazi ya 4% kuri 20 ° C ni 2pA · S, irashobora gukoreshwa mubushyuhe bwicyumba idakonje. Byoroshye gushonga mumazi).

. Methylcellulose isaba uburyo bwo gusimbuza methoxy ya 2.1 Ibicuruzwa byavuzwe haruguru birimo hydroxypropyl methylcellulose hamwe na hydroxypropyl MS = 1.5 ~ 1.8 hamwe na DS = 0.2 ~ 1.0, hamwe n’icyiciro cyo gusimbuza hejuru ya 1.8, kandi byoroshye gushonga muri metani ya anhidrous na ibisubizo bya Ethanol. Thermoplastique hamwe no gushonga amazi. Irashobora kandi gushonga muri hydrocarbone ya chlorine nka methylene chloride na chloroform, hamwe na solge organique nka acetone, inzoga ya isopropyl na alcool ya diacetone. Gukemura kwayo mumashanyarazi kama nibyiza kuruta amazi.

2. Ibintu bigira ingaruka ku bwiza bwa hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose yibintu bya viscosity Igipimo gisanzwe cya viscosity ya hydroxypropyl methylcellulose ni kimwe nizindi ethers ya selile, kandi gipimwa kuri 20 ° C hamwe nigisubizo cyamazi cya 2% nkibisanzwe. Ubukonje bwibicuruzwa bimwe byiyongera uko kwibanda kwiyongera. Kubicuruzwa bifite ubunini bumwe hamwe nuburemere butandukanye bwa molekile, ibicuruzwa bifite uburemere bunini bwa molekile bifite ubwiza bwinshi. Isano ryayo nubushyuhe busa nubwa methylcellulose. Iyo ubushyuhe buzamutse, ibishishwa bitangira kugabanuka, ariko iyo bigeze ku bushyuhe runaka, ubukonje burazamuka butunguranye kandi gelation iba. Ibicuruzwa bito byijimye bifite ubushyuhe bwo hejuru kuruta ibicuruzwa byinshi. Ingingo ya gel ntabwo ijyanye gusa nubwiza bwa ether gusa, ahubwo ifitanye isano nigipimo cyimiterere ya matoxy na hydroxypropyl matsinda muri ether hamwe nurwego rwose rwo gusimbuza. Tugomba kumenya ko hydroxypropyl methylcellulose nayo ari pseudoplastique; ibisubizo byayo birahamye iyo bibitswe mubushyuhe bwicyumba kandi ntibigaragaza ububobere bugabanuka, usibye kwangirika kwimisemburo.

3. Hydroxypropyl methylcellulose ni aside kandi irwanya alkali

Hydroxypropyl methylcellulose ni aside kandi irwanya alkali. Hydroxypropyl methyl selulose ni aside kandi irwanya alkali. Mubisanzwe birahagaze kandi ntabwo bizaterwa nigiciro cya pH murwego rwa PH2 ~ 12. Irashobora kwihanganira urugero runaka rwa acide nkeya, nka acide formique, aside acike, n'indimu. Acide, acide succinic, aside fosifori ariko aside yibanze ifite ingaruka zo kugabanya ubukonje. Alkali nka soda ya caustic, potasiyumu ya caustic, n'amazi ya lime ntacyo ibigiraho, ariko ingaruka zo kongera gato ubukonje bwumuti zizagabanuka buhoro buhoro nyuma.

4. Hydroxypropyl methylcellulose irashobora kuvangwa

Hydroxypropyl methylcellulose igisubizo irashobora kuvangwa namazi ya elegitoronike ya polymer kugirango ibe igisubizo kimwe kandi kibonerana hamwe nubwiza bwinshi. Ibi bikoresho bya polymer birimo polyethylene glycol, acetate ya polyvinyl, polysiloxane, polymethyl vinyl siloxane, hydroxyethyl selulose na methyl selulose. Ibikoresho bya polymer bisanzwe nka acacia gum, inzige zinzige, inzige, nibindi nabyo bivanga neza. igisubizo cyacyo. Hydroxypropyl methylcellulose irashobora kandi kuvangwa na acide stearic cyangwa mannitol palmitate cyangwa sorbitol, kandi ishobora no kuvangwa na glycerine, sorbitol na mannitol. Izi mvange zirashobora gukoreshwa nka hydroxypropyl methylcellulose yamashanyarazi.

5. Hydroxypropyl methylcellulose ntishobora gushonga mumazi

Hydroxypropyl methylcellulose ntishobora gushonga mumazi ya selile yamashanyarazi kandi irashobora guhuzwa-na aldehydes, bigatuma izo ether zishonga mumazi zigwa mumuti hanyuma zigahinduka amazi. Kandi ukore hydroxypropyl methylcellulose idashonga muri aldehydes, formaldehyde, glyoxal, acide succinic, dialdehyde, nibindi. Muri byo, glyoxal ikora vuba, bityo ikoreshwa mu nganda Glyoxal ikunze gukoreshwa nkumukozi uhuza ibicuruzwa. -Umukozi uhuza. Ingano yubu bwoko bwa cross-ihuza agent mugisubizo ni 0.2% kugeza 10% bya misa ya ether, kandi ibyiza ni 7% kugeza 10%. Niba glyoxal ikoreshwa, 3,3% kugeza 6% irakwiriye cyane. Ubushyuhe rusange bwo kuvura ni 0 ~ 30 ℃ kandi igihe ni 1 ~ 120min. Igikorwa cyo guhuza ibikorwa kigomba gukorwa mugihe cya acide. Mubisanzwe, acide organic organique cyangwa acide karubasi ya acide yongewe kumuti kugirango uhindure pH yumuti kuri 2 kugeza kuri 6, byaba byiza hagati ya 4 na 6, hanyuma aldehydes ikongerwamo kugirango ikore reaction ihuza. Acide zikoreshwa zirimo aside hydrochloric, aside sulfurike, aside fosifori, aside aside, aside acike, aside glycolike, aside succinic cyangwa acide citricike, muri yo harimo aside irike cyangwa acide acike ni nziza, na aside ya formike ni nziza. Acide na aldehydes birashobora kandi kongerwaho icyarimwe kugirango bihuze igisubizo murwego rwa pH wifuza. Iyi reaction ikoreshwa kenshi muntambwe yanyuma yuburyo bwo gutegura selile ya selile kugirango ether ya selulose idashonga kandi byoroshe gukaraba no kwezwa namazi ya 20 ~ 25 ° C. Iyo ukoresheje ibicuruzwa, urashobora kongeramo ibintu bya alkaline kubisubizo byibicuruzwa kugirango uhindure pH yumuti kugirango ube alkaline kugirango ibicuruzwa bishobore gushonga vuba mubisubizo. Ubu buryo burashobora kandi gukoreshwa mugihe hateguwe firime ikoresheje igisubizo cya selile ether hanyuma firime igatunganyirizwa muri firime idashonga.

6. Hydroxypropyl methylcellulose anti-enzyme

Inkomoko ya selile ikomoka kuri hydroxypropyl methylcellulose irwanya insimburangingo. Kurugero, buri tsinda rya anhydroglucose rihujwe neza nitsinda risimbuye kandi ntirishobora kwandura mikorobe no kwandura. Ariko, mubyukuri, agaciro ko gusimbuza ibicuruzwa byarangiye karenze 1. Irashobora kandi guteshwa agaciro na enzymes, ibyo bikaba byerekana ko urugero rwo gusimbuza buri tsinda mumurongo wa selile rudasa, kandi mikorobe irashobora kwangirika hafi yitsinda rya anhydroglucose ridafite ishingiro. isukari, ishobora kwinjizwa na mikorobe nk'ibiryo. Kubwibyo, niba urwego rwo gusimbuza ether gusimbuza selile rwiyongera, kurwanya ethers ya selile yibitero bya enzymatique biziyongera. Biravugwa ko mugihe cyagenzuwe, hydroxypropyl methylcellulose (DS = 1.9), methylcellulose (DS = 1.83), methylcellulose (DS = 1.66), hydroxyethylcellulose (1.7%) Ibibyimba bisigaye ni 13.2%, 7.3%, 3.8% na 1.7% bikurikiranye. Hydroxypropyl methylcellulose ifite ubushobozi bukomeye bwo kurwanya enzyme. Birashobora kugaragara ko hydroxypropyl methylcellulose ifite imbaraga zo kurwanya enzyme nziza, hamwe no gukwirakwiza kwayo neza, kubyimba no gukora firime, irashobora gukoreshwa mumyenda ya emulsiya, nibindi, kandi mubisanzwe ntibisaba kongeramo imiti igabanya ubukana. Ariko rero, kugirango wirinde igisubizo kubikwa igihe kirekire cyangwa ibishoboka byanduye hanze, hashobora kongerwamo imiti igabanya ubukana, kandi guhitamo imiti igabanya ubukana bishobora kugenwa hashingiwe ku bisabwa bya nyuma by’igisubizo. Fenilmercuric acetate na fluorosilicate ya manganese ni ibintu birinda ibintu neza, ariko ni uburozi kandi bigomba gukemurwa neza. Mubisanzwe, mg 1 kugeza 5 mg ya fenilmercuric acetate irashobora kongerwa kuri litiro yumuti.

7. Imikorere ya hydroxypropyl methylcellulose membrane

Hydroxypropyl methylcellulose imiterere ya firime Hydroxypropyl methylcellulose ifite imiterere myiza yo gukora film. Iyo igisubizo cyamazi cyacyo cyangwa igisubizo kama kama gishyizwe kumasahani yikirahure, gihinduka firime idafite ibara, ibonerana kandi ikomeye nyuma yo gukama. . Ifite ubushyuhe bwiza kandi ikomeza gukomera ku bushyuhe bwinshi. Niba hiyongereyeho plasitiki ya hygroscopique, kuramba no guhinduka birashobora kongerwa, kandi guhinduka birashobora kunozwa. Plastiseri nka glycerol na sorbitol nibyo byiza cyane. Igisubizo rusange cyibisubizo ni 2% ~ 3%, naho dosiye ya plastiseri ni 10% ~ 20% ya selile ya ether. Niba ibintu bya plasitike bisabwa kuba hejuru, syneresis ya colloid izaba munsi yubushyuhe bwinshi. Imbaraga zingana za firime hamwe na plasitike yongeweho irarenze cyane iyo firime idafite plastike, kandi iriyongera hamwe nubunini bwa plastike yongeyeho. Hygroscopicity ya firime nayo yiyongera hamwe nubunini bwa plastike.