Hydroxypropyl Methyl Cellulose

Hydroxypropyl methyl selilee (HPMC) nuruvange rwinshi hamwe nurwego runini rwa porogaramu mu nganda zitandukanye. Iyi selile ya selulose ikomatanyirizwa muguhindura imiti ya selile karemano, bikavamo ibicuruzwa bifite imitungo yihariye bituma bigira agaciro mubice nkubwubatsi, imiti, ibiryo, amavuta yo kwisiga, nibindi byinshi. Muri ubu bushakashatsi bwimbitse, tuzacengera muburyo, imiterere, uburyo bwo gukora, hamwe nuburyo butandukanye bwa HPMC.

Imiterere n'imiterere:
Hydroxypropyl methyl selulose ni igice cya sintetike ya polymer ikomoka kuri selile, polimeri kama nyinshi cyane kwisi, iboneka cyane mubiti cyangwa ipamba. Binyuze mu guhindura imiti, amatsinda ya hydroxyl (-OH) kumugongo wa selile asimbuzwa methyl (-CH3) na hydroxypropyl (-CH2CHOHCH3).

Urwego rwo gusimbuza (DS) rwamatsinda ya methyl na hydroxypropyl rugena imiterere ya HPMC. Indangagaciro za DS zo hejuru zituma hydrophobicity yiyongera kandi igabanuka ryamazi, mugihe indangagaciro za DS zo hasi ziganisha kumazi meza hamwe na gel.

HPMC yerekana ibintu byinshi byingirakamaro, harimo:

1 Kubyimba: HPMC ikora nkibyimbye bifatika mubisubizo byamazi, itanga igenzura ryijimye kandi igatezimbere ituze ryimikorere.

2 Kubika Amazi: Kamere ya hydrophilique ituma HPMC igumana amazi, ikongerera imbaraga nogukora ibikoresho bishingiye kuri sima no kunoza ubuhehere bwibintu bitandukanye.

3 Imiterere ya firime: HPMC irashobora gukora firime zibonerana kandi zoroshye iyo zumye, bigatuma zikoreshwa mubisabwa bisaba gutwikira firime cyangwa imiterere ya barrière.

4 Igikorwa cyo hejuru: Yerekana ibikorwa byubuso, bifasha muri emulisation no guhagarika ihagarikwa na emulisiyo.

5 Biocompatibilité: HPMC ntabwo ari uburozi, ibinyabuzima bishobora kwangirika, hamwe na biocompatable, bigatuma ibera imiti n’ibiribwa.

Uburyo bwo gukora:
Umusaruro wa HPMC urimo intambwe nyinshi:

1 Isoko rya Cellulose: Cellulose ikomoka mubikoresho bishobora kuvugururwa nkibiti byimbuto cyangwa ipamba.

2 Etherification: Cellulose ikorwa na oxyde ya propylene kugirango itangize amatsinda ya hydroxypropyl, hakurikiraho reaction hamwe na methyl chloride yo kongeramo amatsinda ya methyl. Urwego rwo gusimburwa rugenzurwa neza muriki gikorwa.

3 Isuku: Cellulose yahinduwe isukurwa kugirango ikureho ibicuruzwa n’ibihumanya, bivamo ibicuruzwa bya nyuma bya HPMC.

Porogaramu:
Hydroxypropyl methyl selulose isanga porogaramu zitandukanye mubikorwa bitandukanye:

1 Ubwubatsi: Mubikoresho bishingiye kuri sima, HPMC ikora nkibikoresho bigumana amazi, bigateza imbere imikorere, bifata, kandi biramba bya minisiteri, plaster, hamwe na tile.

2 Imiti yimiti: Ikoreshwa nka binder, firime yambere, kubyimbye, hamwe na stabilisateur mubinini, capsules, ibisubizo byamaso, hamwe nibisobanuro byingenzi.

3 Ibiryo: HPMC ikora nk'ibyimbye, stabilisateur, na emulisiferi mu bicuruzwa byibiribwa nka sosi, imyambarire, amavuta ya ice, hamwe n imigati.

4 Kwita ku muntu ku giti cye: Mu mavuta yo kwisiga no kwita ku muntu ku giti cye, HPMC ikoreshwa nk'umubyimba, uhagarika, filime yahoze, hamwe na moisturizer muri cream, amavuta yo kwisiga, shampo, na geles.

5 Irangi hamwe na Coatings: HPMC yongerera ubwiza, kwihanganira sag, hamwe no gukora firime yibiranga bishingiye kumazi, ibifatika, hamwe nububiko.

Umwanzuro:
Hydroxypropyl methyl selulose ni polymer ikora cyane igira uruhare runini mubikorwa byinshi byinganda nubucuruzi. Ihuza ryihariye ryimitungo, harimo kubyimba, kubika amazi, gukora firime, hamwe na biocompatibilité, bituma iba ingenzi mumirenge kuva ubwubatsi kugeza imiti n'ibiribwa. Mugihe ikoranabuhanga rigenda ritera imbere hamwe nuburyo bushya bugaragara, ibyifuzo bya HPMC biteganijwe ko bizakomeza kwiyongera, bigatera imbere guhanga udushya muburyo bwo kubyaza umusaruro no kubishyira mu bikorwa.