Wibande kuri ethers ya Cellulose

HPMC ikoresha mububiko bwa tableti

HPMC ikoresha mububiko bwa tableti

ibinini byanditseho ni muri rusange ikoreshwa muburyo bukomeye bwo gutegura, ukurikije iibinini byanditseho ibikoresho birashobora kugabanywamo ifuibinini byanditseho, pelletibinini byanditseho, agaceibinini byanditseho, tabletibinini byanditseho, capsuleibinini byanditseho; Ukurikijeibinini byanditseho ibikoresho bigabanijwemo isukariibinini byanditsehoigice cya firimeibinini byanditseho, firimeibinini byanditseho (hashingiwe kubintu byinshi bya polymer, harimo na entericibinini byanditseho), ibikoresho bidasanzweibinini byanditseho (nka aside stearic, paraffin, polysaccharide); Ukurikijeibinini byanditseho ikoranabuhanga, irashobora kugabanywamo sprayibinini byanditseho, kwibizaibinini byanditseho, igitutu cyumyeibinini byanditseho, amashanyaraziibinini byanditseho no kumurikaibinini byanditseho. Muri byo, sasaibinini byanditseho ni Byakoreshejwe cyane. Ihame ryayo ni uguteraibinini byanditseho amazi mu bitonyanga bitwikiriye hejuru yibikoresho (ifu, ibice, ibinini). Kandi byumye vuba kugirango ubeibinini byanditseho urwego: ukurikije iibinini byanditseho intego igabanijwemo amaziibinini byanditseho, igifuibinini byanditseho, idashobora gukemukaibinini byanditseho, kurekura buhoroibinini byanditsehoentericibinini byanditseho.

 

Uruhare rwaibinini byanditseho ikubiyemo: (1) kutagira amazi, urumuri, kwigunga ikirere kugirango byongere ibiyobyabwenge; (2) Gupfuka impumuro mbi, gabanya kubyutsa; (3) Kunoza isura, byoroshye kumenya; .ibinini byanditseho ibikoresho bigomba kugira ibisabwa bikurikira: bidafite uburozi, nta inertie yimiti, bihamye mubushyuhe, urumuri, amazi, umwuka, kandi ntibitwara hamweibinini byanditseho ibiyobyabwenge; (2) irashobora gushonga muburyo butatanye muburyo bwo gukwirakwiza bubereyeibinini byanditseho:.Gukemura kwayo bigomba kuba byujuje ibisabwa - - bikosowe, rimwe na rimwe ntibigomba guterwa na PH, rimwe na rimwe birashobora gushonga gusa murwego runaka rwa PH. Ubwoko bwibikoresho bifite hejuru biranga icyarimwe ntibigaragara cyane, impamvu ikunda gukoresha ivanzeibinini byanditseho ibikoresho byinshi, kugirango twigire kuri buriwese.

 

Tabletibinini byanditseho ni ikoreshwa cyane, akenshi ikoresha inkonoibinini byanditseho n'umuyoboro washyinguweibinini byanditseho (gukora nezaibinini byanditseho imashiniibinini byanditseho), ibyanyuma nibyiza kuri firimeibinini byanditseho. Uburiri bwuzuyeibinini byanditseho ni byiza cyane kubikoresho bifite ingano ntoya nka pellet na poro. Ugereranije nisukariibinini byanditseho, firimeibinini byanditseho ifite ibyiza byinshi:( 1) Gabanya igihe no kugabanya ikiguzi cyibikoresho; .6) Irashobora kurinda neza ibicuruzwa ingaruka zumucyo, umwuka namazi; (7) Nta ngaruka mbi ku gihe cyo gusenyuka:( 8) ibicuruzwa byiza:( 9) itanga amahirwe yo gukoresha amaziibinini byanditseho; Inzira n'ibikoresho birashobora kuba bisanzwe. Noneho iterambere ryibicuruzwa bishyaibinini byanditseho imyiteguro muri rusange ifata firimeibinini byanditseho, firimeibinini byanditseho imiti yibanze igizwe na agent ikora firime (ibinini byanditseho ibikoresho), ibishishwa, plasitike, ibara, irashobora kandi kongeramo ibintu bitera pore, ibyuzuza bitangirika, nibindi .. Ibigize firimeibinini byanditseho kwandikirwa nurufunguzo rwo gutsindaibinini byanditseho. Kugeza ubu, firime ikora amaziibinini byanditseho ibikoresho bikunze gukoreshwa birimo hydroxypropyl methyl selulose (HPMC) na hydroxypropyl selulose (HPC). Polyethylene glycol (PEG), polyethylene pyrrolidone (PVP), ibikoresho bya enteric-soluble birimo enterin-soluble acrylic resin, hydroxypropyl methyl selulose phthalate (HPMCP). Cellulose acetate phthalate ester (CAP). Shellac, ibikoresho bidashonga birimo Ethyl selulose (EC), zein.

Mu myaka yashize, firimeibinini byanditseho yateye intambwe ishimishije. Ibisanzweibinini byanditseho Sisitemu ikoreshaHPMC(hydroxypropyl methylcellulose) nka polymer nyamukuru, nubu iracyakoreshwa henshi. H.PMC-bishingiyeibinini byanditseho sisitemu itanga imikorere ihagije, ariko haracyariho umwanya wo gutera imbere. HPMCibinini byanditseho firime ntishobora gukurikiza tablet neza, mubisanzwe birebireibinini byanditseho igihe, bivamo umusaruro utinze. IntangiriroPVA ishingiye ibinini byanditseho sisitemu yarushijeho kunoza imikorere, bivamo ibyizaibinini byanditseho imikorere nuburyo bwihuse bwo gukora, bivuze ko inenge idakunze kugaragara mubinini.

Mugihe ubwiza bwa HPMC bwiyongera, imbaraga za firime zakozwe na HPMC ziyongera uko bikwiye, kandi amaherezo igera ku mbaraga nini za firime ntiziyongera hamwe no kwiyongera kwijimye rya HPMC.

Muriibinini byanditseho, kugirango tugere kubikorwa byiza cyaneibinini byanditseho, akenshiibinini byanditseho ibintu bikomeye byamazi, bizaganisha kuriibinini byanditseho amazi ya viscosity ni menshi cyane, hitamo ubukonje buke HPMC irashobora gukemura neza iki kibazo, ariko biganisha kuri firime imbaraga. Kuringaniza ibyo bibazo byimpanga, kuvanga polymers byabaye igikoresho rusange.

NkaHPMCE15 ibirimo byiyongera buhoro buhoro, ubwiza bwuruvange rwaHPMCE5 naHPMCE15 nayo yiyongera buhoro buhoro.

 

Mu isukariibinini byanditseho, twavuye kandi mubuhanzi tujya mubumenyi. Ibicuruzwa bisizwe nisukari birashimishije muburyo bwiza kuko bifite uburyohe, burabagirana, buryoshye butwikiriye uburyohe bukaze. Ariko imbogamizi zikomeye mu isukariibinini byanditseho kubeshya mu musaruro no kubyara. Isukariibinini byanditseho ni akazi gakomeye kandi gatwara igihe kinini kandi birashobora gutandukana muburyo butandukanye bitewe numuntu ukoraibinini byanditseho.


Igihe cyo kohereza: Ukuboza-23-2023
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