HPMC muri farumasi

Imiti ikoreshwa na hydroxypropyl methyl selulose (HPMC) ni intungamubiri zitari ionic selulose ether, kuri ubu ni yo nini mu gihugu no mu mahanga ikoresha imiti ivura imiti - a, kuko imiti ivura ifite imyaka irenga 30 amateka. Ntabwo ari impumuro nziza, uburyohe, ntabwo ari uburozi, gushonga mumazi akonje, gelation mumazi ashyushye, urwego rwo hasi rwijimye HPMC irashobora gukoreshwa nkibikoresho bifata neza, bifata ibyemezo hamwe na agent ihagarika urwego rwo hejuru rwijimye HPMC irashobora gukoreshwa mugutegura ibikoresho bivanze murwego rwo gukomeza-kurekura ibinini, bikomeza-kurekura capsules, hydrophilic gel urwego rukomeza-kurekura ibinini byahagaritswe, bigenzurwa kurekura hamwe numuyoboro wa pore.

Ibikoresho bya farumasi bivuga ibicuruzwa biva mu mahanga hamwe n’imigereka ikoreshwa mu gukora no gutanga ibiyobyabwenge. Ikintu, usibye ibikoresho bikora, cyasuzumwe neza kubwumutekano kandi gishyirwa mubicuruzwa bya farumasi. Ibikoresho bya farumasi bifite imirimo yingenzi yo gushonga, gufasha guseswa, gutinda no kugenzurwa hiyongereyeho gushiraho, kuzuza abatwara no kuzamura umutekano, bishobora kugira ingaruka kumiterere, umutekano nubushobozi bwibiyobyabwenge.

Hydroxypropyl methyl selulose HPMC ni kimwe mu bintu bivura imiti mu gihugu ndetse no hanze yacyo, kikaba kimaze imyaka gikoreshwa nk'imiti ivura imiti. Ntabwo ari impumuro nziza, uburyohe kandi ntabwo ari uburozi, gushonga mumazi akonje na gelatine mumazi ashyushye. HPMC nkibikoresho bisanzwe bya hydrophilique polymer yimiti ifasha imiti, ntibishobora gukoreshwa gusa nka tablet, granule, ibinini bifata ibinini kandi bitavunika, ibikoresho byo gutwika firime, birashobora kandi gukoreshwa nkumukozi wa colloidal hamwe nu mukozi wo guhagarika, kurekura buhoro hamwe no guhagarika imyiteguro yo gusohora, kugenzurwa kurekura umukozi nogukora pore, kimwe nuwitwaye ibintu bitatanye.

HPMC nkumukozi uhuza kandi usenya. HPMC nk'igitereko irashobora kugabanya imikoreshereze y’imiti, kugirango ibiyobyabwenge byoroshye gutose, kandi amazi yacyo ashobora kwaguka inshuro magana, bityo birashobora kunoza cyane gusesa cyangwa kurekura ibinini. HPMC ifite ububobere bukomeye, kubwimiterere yibikoresho byoroshye cyangwa byoroshye ibikoresho byibanze bishobora kongera ububobere bwayo, bikongera ububobere bwayo. HPMC ifite ubukonje buke irashobora gukoreshwa nkibikoresho bisenya kandi bigasenyuka, ubukonje bwinshi gusa nkububiko, amafaranga aratandukanye ukurikije icyitegererezo nibisabwa, amafaranga rusange ni 2% -5%.

HPMC ikoreshwa nkibikoresho bigenzurwa byo gutegura umunwa. HPMC ni hydrogel yibikoresho bisanzwe bikoreshwa mugutegura-kurekura. HPMC ifite ubukonje buke (5 ~ 50mPa • s) irashobora gukoreshwa nka binder, agent-yongerera imbaraga hamwe nubufasha bwo guhagarika, mugihe HPMC ifite urwego rwo hejuru rwinshi (4000 ~ 100000mPa • s) irashobora gukoreshwa mugutegura ibikoresho bivanze murwego rwo gukomeza-kurekura ibinini, bikomeza-kurekura capsules, hydrophilic gel urwego rukomeza-kurekura ibinini nkibibuza. HPMC irashobora gushonga mumazi ya gastricique, ifite ibyiza byo guhindagurika neza, amazi meza, ubushobozi bwo gupakira ibiyobyabwenge hamwe nibiranga ibiyobyabwenge ntabwo bigira ingaruka kuri pH, nibindi, nibikoresho byingenzi bitwara hydrophilique muburyo bwo gutegura irekurwa rirambye, mubisanzwe ikoreshwa nka hydrophilic gel framework hamwe nibikoresho byo gutwika bihoraho byo gusohora, kandi bigakoreshwa mugutegura igifu, kurekura ibiyobyabwenge bya firime.

HPMC nkibikoresho byo gutwika firime. HPMC ifite firime nziza, ikora firime ibonerana, irakomeye, umusaruro ntiworoshye gukomera, cyane cyane kubyinjira byoroshye byoroshye, imiti idahindagurika, hamwe nigice cyo kwigunga gishobora guteza imbere cyane ibiyobyabwenge, bikarinda ibara rya firime. Ugereranije no gukora firime ya gelatin, firime ya HPMC ifite uburinganire bwiza no kohereza urumuri. HPMC ifite ibisobanuro bitandukanye byijimye, guhitamo bikwiye, ubwiza bwa coating, isura nibyiza kuruta gukoresha ibindi bikoresho, bikunze gukoreshwa byibanda kuri 2% -10%.

HPMC nkumukozi wo guhagarika. Guhagarika imyiteguro y'amazi ikunze gukoreshwa muburyo bwa dosiye yubuvuzi, aribwo buryo bwo gukwirakwiza imiti itandukanye yimiti ikomeye idashobora gukemuka mubitangazamakuru bikwirakwiza amazi. Ihame rya sisitemu rigena ubuziranenge bwo gutegura amazi yahagaritswe. HPMC colloidal igisubizo irashobora kugabanya ubukana-bwimbere bwimiterere, kugabanya ingufu zubusa hejuru yingingo zikomeye, kuburyo sisitemu yo gukwirakwiza heterogeneous ikunda guhagarara neza, nikintu cyiza cyo guhagarika. HPMC ikoreshwa nkibyimbye kumaso yijisho, hamwe nibirimo 0.45% -1.0%.