Nigute ushobora gutegura igisubizo cya HPMC?

Gutegura hydroxypropyl methylcellulose (HPMC) ibisubizo bikubiyemo intambwe nyinshi kandi bisaba kwitondera neza birambuye. HPMC isanzwe ikoreshwa nkibikoresho bya firime mu nganda zimiti n’ibiribwa. Ibisubizo bitwikiriye bikoreshwa mubinini cyangwa granules kugirango bitange urwego rukingira, kunoza isura, kandi byoroshye kumira.

1. Intangiriro yo gutwikira HPMC:

Hydroxypropylmethylcellulose (HPMC) ni polymer ishingiye kuri selile ikomoka kumibabi y'ibimera. Bitewe nuburyo bwo gukora firime no kubyibuha, ikoreshwa cyane muma firime ya firime mubikorwa bya farumasi nibiribwa.

2. Ibikoresho bisabwa:

Hydroxypropyl methylcellulose ifu
Sukura amazi
Ibikoresho bya plastiki cyangwa bidafite ingese
Ibikoresho bikurura (urugero: magnetiki stirrer)
Ibikoresho byo gupima (umunzani, gupima silinderi)
metero pH
Isafuriya ya plastiki cyangwa idafite ingese
Itanura rishyushye

3.Programme:

Gupima HPMC:

Gupima neza umubare ukenewe w'ifu ya HPMC ukurikije ifu yifuzwa. Kwishyira hamwe mubisanzwe biri hagati ya 2% na 10%.

Tegura amazi meza:

Koresha amazi asukuye kugirango urebe ko adafite umwanda ushobora kugira ingaruka ku bwiza bwawo. Amazi agomba kuba mubushyuhe bwicyumba.

Ikwirakwizwa rya HPMC:

Buhoro buhoro ongeramo ifu ya HPMC ipimye mumazi asukuye mugihe ukomeje. Ibi birinda guhubuka.

Kangura:

Kangura imvange ukoresheje imashini ya magnetiki cyangwa ikindi gikoresho gikurura kugeza ifu ya HPMC ikwirakwijwe mumazi.

Guhindura pH:

Gupima pH yumuti wa HPMC ukoresheje metero pH. Nibiba ngombwa, pH irashobora guhindurwa wongeyeho aside nkeya cyangwa base ukurikije. PH nziza yo gutwikisha firime mubisanzwe iri hagati ya 5.0 kugeza 7.0.

Kuvomera no gusaza:

Igisubizo cya HPMC cyemerewe kuyobora no gusaza mugihe runaka. Ibi bizamura imiterere yo gukora firime. Igihe cyo gusaza kirashobora gutandukana ariko mubisanzwe biri mumasaha 2 kugeza 24.

muyunguruzi:

Shungura igisubizo cya HPMC kugirango ukureho ibice byose bidakemutse cyangwa umwanda. Iyi ntambwe ningirakamaro kugirango ubone igisubizo cyoroshye, gisobanutse neza.

Guhindura ibice:

Gupima ubwiza bwibisubizo hanyuma ubihindure kurwego rwifuzwa. Viscosity igira ingaruka kuburinganire no kubyimbye.

Guhuza ibizamini:

Gerageza guhuza igisubizo cya coating hamwe na substrate (ibinini cyangwa granules) kugirango umenye neza hamwe na firime.

Uburyo bwo gutwikira:

Koresha isafuriya ikwiye kandi ukoreshe imashini itwikiriye kugirango ushireho igisubizo cya HPMC kuri tableti cyangwa granules. Hindura umuvuduko winkono nubushyuhe bwikirere kugirango ubone neza.

kumisha:

Ibinini bisize cyangwa granules byumye mu ziko ryashyutswe nubushyuhe kugeza igihe ubushyuhe bwifuzwa bugerweho.

QC:

Kora igenzura ryiza ryibicuruzwa bitwikiriye harimo isura, ubunini hamwe nuburyo bwo gusesa.

4.mu mwanzuro:

Gutegura ibisubizo bya HPMC bikubiyemo urukurikirane rwintambwe zifatika kugirango hamenyekane ubwiza nuburyo bwiza. Gukurikiza inzira zagenwe hamwe ningamba zo kugenzura ubuziranenge ni ngombwa kugirango haboneke ibisubizo bihamye kandi byizewe mu nganda zimiti n’ibiribwa. Buri gihe ukurikize uburyo bwiza bwo gukora (GMP) nubuyobozi bujyanye nayo mugihe cyo gutwikira.