Ni bangahe hydroxypropyl methylcellulose ikoreshwa?

Hydroxypropyl methylcellulose (HPMC) ni selile ya nonionic selile ikoreshwa cyane mubikorwa bitandukanye byinganda na farumasi. Ibikorwa byayo byingenzi birimo kubyimbye, firime yambere, stabilisateur, emulifier, guhagarika agent no gufatira. HPMC ikoreshwa cyane muri farumasi, kwisiga, ibiryo, ibikoresho byubaka nizindi nganda. Imikoreshereze yacyo iterwa numurima wihariye wa progaramu, ingaruka zisabwa zisabwa, ibindi bintu bigize formulaire nibisabwa byihariye.

1. Imiti yimiti

Mu myiteguro ya farumasi, HPMC ikoreshwa nkumukozi uhoraho-urekura, ibikoresho byo gutwikira, firime yahoze hamwe na capsule. Mu bisate, imikoreshereze ya HPMC muri rusange iri hagati ya 2% na 5% yuburemere bwose kugirango igenzure igipimo cy’ibiyobyabwenge. Ku bisate bikomeza kurekurwa, imikoreshereze irashobora kuba myinshi, ndetse igera kuri 20% cyangwa irenga, kugirango ibiyobyabwenge bishobore gusohoka buhoro buhoro mugihe kirekire. Nkibikoresho byo gutwikira, imikoreshereze ya HPMC isanzwe iri hagati ya 3% na 8%, bitewe nuburinganire busabwa hamwe nibisabwa bikora.

Inganda zikora ibiribwa

Mu nganda zibiribwa, HPMC ikoreshwa kenshi mubyimbye, emulisiferi, ihagarika ibintu, nibindi. Ikoreshwa nkigisimbuza amavuta mubiribwa bya karori nkeya kuko ishobora gutanga uburyohe busa nibinure. Amafaranga akoreshwa mu biryo ubusanzwe ari hagati ya 0.5% na 3%, bitewe n'ubwoko n'ibicuruzwa. Kurugero, mubinyobwa, isosi cyangwa ibikomoka ku mata, ingano ya HPMC ikoreshwa mubisanzwe ni mike, hafi 0.1% kugeza 1%. Mu biribwa bimwe na bimwe bigomba kongera ububobere cyangwa kunoza imiterere, nka noode ihita cyangwa ibicuruzwa bitetse, ingano ya HPMC yakoreshejwe irashobora kuba myinshi, mubisanzwe hagati ya 1% na 3%.

3. Umwanya wo kwisiga

Mu kwisiga, HPMC ikoreshwa cyane nkibyimbye, stabilisateur na firime byahoze mumavuta yo kwisiga, amavuta, shampo, igicucu cyamaso nibindi bicuruzwa. Igipimo cyacyo muri rusange ni 0.1% kugeza kuri 2%, bitewe nubusembwa bwibicuruzwa nibiranga ibindi bintu. Mu kwisiga bimwe na bimwe byihariye, nkibicuruzwa byita ku ruhu cyangwa izuba rikenera gukora firime, ingano ya HPMC yakoreshejwe irashobora kuba myinshi kugirango ibicuruzwa bibe bigize urwego rumwe rukingira uruhu.

4. Ibikoresho byo kubaka

Mu bikoresho byubaka, HPMC ikoreshwa cyane mubicuruzwa nka sima, ibicuruzwa bya gypsumu, amarangi ya latx hamwe na tile yifashisha kugirango tunoze imikorere yubwubatsi bwibikoresho, byongere igihe cyo gufungura, kandi binonosore imiti igabanya ubukana no kurwanya. Umubare wa HPMC ukoreshwa mubikoresho byubaka mubisanzwe uri hagati ya 0.1% na 1%, bitewe nibisabwa. Kubikoresho bya sima cyangwa ibikoresho bya gypsumu, ingano ya HPMC ni 0.2% kugeza 0.5% kugirango barebe ko ibikoresho bifite imikorere myiza yubwubatsi na rheologiya. Mu irangi rya latex, ingano ya HPMC muri rusange ni 0.3% kugeza 1%.

5. Amabwiriza n'ibipimo

Ibihugu n'uturere dutandukanye bifite amabwiriza n'amahame atandukanye yo gukoresha HPMC. Mu rwego rw'ibiribwa n'ubuvuzi, ikoreshwa rya HPMC rigomba kubahiriza ibiteganijwe mu mabwiriza abigenga. Kurugero, muri EU no muri Amerika, HPMC izwi cyane nkumutekano (GRAS), ariko imikoreshereze yayo iracyakeneye kugenzurwa ukurikije ibyiciro byihariye nibisabwa. Mu bijyanye n’ubwubatsi n’amavuta yo kwisiga, nubwo ikoreshwa rya HPMC ridakurikiza amategeko abigenga, ingaruka zishobora kuba ku bidukikije, umutekano w’ibicuruzwa n’ubuzima bw’umuguzi ziracyakenewe gutekerezwa.

Nta gipimo gihamye cyamafaranga ya HPMC yakoreshejwe. Biterwa cyane nuburyo bwihariye bwo gusaba, ingaruka zisabwa zikenewe, hamwe no guhuza ibindi bintu bigize formulaire. Muri rusange, umubare wa HPMC wakoreshejwe uri hagati ya 0.1% na 20%, kandi agaciro kihariye kagomba guhinduka ukurikije igishushanyo mbonera hamwe nibisabwa n'amategeko. Mubikorwa nyabyo, abakozi ba R&D mubisanzwe bahindura bashingiye kumibare yubushakashatsi hamwe nuburambe kugirango bagere ku ngaruka nziza zo gukoresha no gukoresha neza. Muri icyo gihe, ikoreshwa rya HPMC rigomba kubahiriza amahame n’inganda bijyanye n’inganda kugira ngo umutekano wubahirizwe n’ibicuruzwa.