Nigute hydroxypropylcellulose ikorwa?

Hydroxypropylcellulose (HEC) ikomoka kuri selile, polymer karemano iboneka murukuta rw'utugingo ngengabuzima. HPC ikoreshwa cyane mu nganda zinyuranye nka farumasi, amavuta yo kwisiga n’inganda zikora ibiribwa kubera uburyo bwiza bwo gukora firime no kubyimba. Synthesis ya hydroxypropylcellulose ikubiyemo intambwe nyinshi kandi inzira irashobora kuba ingorabahizi.

Intangiriro kuri hydroxypropylcellulose:

1. Gukoresha selile nkibikoresho byo gutangira:

Inkomoko nyamukuru ya selile ni ibikoresho byibimera nkibiti cyangwa ipamba. Cellulose ni polymer igizwe numurongo wa glucose uhujwe na β-1,4-glycosidic. Ifite urwego rwo hejuru rwa polymerizasiya, hamwe nibihumbi bya glucose bigize iminyururu ndende.

2. Igisubizo cya Etherification:

Synthesis ya hydroxypropylcellulose ikubiyemo kwinjiza amatsinda ya hydroxypropyl mumugongo wa selile ukoresheje etherification. Iyi reaction mubisanzwe ikubiyemo gukoresha okiside ya propylene nka alkylating agent.

Cellulose + okiside ya propylene → alkali-catalizike hydroxypropyl selulose + yibicuruzwa bya selile + propylene oxyde alkali-catalizike hydroxypropyl selile + by-ibicuruzwa

Isesengura fatizo ningirakamaro kugirango uteze imbere reaction hagati ya selile hydroxyl selile na okiside ya propylene. Iyi ntambwe isanzwe ikorwa mugihe cyagenzuwe kugirango harebwe urwego rwifuzwa rwo gusimbuza (DS) rwamatsinda ya hydroxypropyl kumurongo wa selile.

3. Hydroxypropylation:

Hydroxypropylation ikubiyemo kongeramo amatsinda ya hydroxypropyl mumugongo wa selile. Ihinduka ritanga uburyo bwiza bwo gukemuka hamwe nibindi byifuzwa kuri selile ya polymer. Imiterere yibikorwa, harimo ubushyuhe, umuvuduko nigihe cyo kubyitwaramo, bigenzurwa neza kugirango ugere kubintu byifuzwa.

4. Kuvura alkali:

Nyuma ya hydroxypropylation, imiti ya alkaline ikoreshwa mugutandukanya umwanda wa acide usigaye kandi ugahindura pH yuruvange rwa reaction. Iyi ntambwe ningirakamaro kubikorwa byo kwezwa nyuma.

5. Intambwe zo kweza:

Nyuma ya reaction ya etherification, intambwe nyinshi zo kwezwa zirakorwa kugirango haboneke hydroxypropylcellulose yuzuye. Izi ntambwe zishobora kubamo:

Gukaraba: Koza ivangavanga rya reaction kugirango ukureho reagent zisigaye, ibicuruzwa-na selile idakozwe.

Kurungurura: Filtration ikoreshwa mugutandukanya umwanda ukomeye nuruvange rwa reaction.

Kuma: hydroxypropyl selulose itose noneho iruma kugirango ikureho ubuhehere busigaye.

6. Kugenzura ibiro bya molekulari:

Uburemere bwa molekuline ya hydroxypropylcellulose irashobora kugenzurwa mugihe cya synthesis kugirango ihuze imiterere yabyo mubikorwa byihariye. Ibi bigerwaho muguhindura imiterere yimyitwarire, nkubunini bwa reagent nigihe cyo kubyitwaramo.

Umusaruro w'inganda:

1. Inzira yigihe kimwe cyangwa ikomeza:

Umusaruro wa hydroxypropyl selulose urashobora gukorwa mubice cyangwa inzira ikomeza. Inzira yicyiciro irakwiriye kubyara umusaruro muto, mugihe inzira ikomeza irakwiriye cyane mubikorwa binini.

2. Kugenzura ubuziranenge:

Ingamba zo kugenzura ubuziranenge zishyirwa mubikorwa mubyiciro byose byumusaruro kugirango habeho guhuza no kweza ibicuruzwa byanyuma. Ubuhanga bwo gusesengura nka chromatografiya, spekitroscopi nubushakashatsi bwa rheologiya bikoreshwa mugusuzuma ibipimo byingenzi nkurwego rwo gusimbuza, uburemere bwa molekile nubuziranenge.

Porogaramu ya Hydroxypropyl Cellulose:

1. Inganda zimiti:

Hydroxypropylcellulose ikoreshwa cyane mugutegura imiti nka binder, disintegrant and control agent. Guhuza kwayo nibiyobyabwenge byinshi hamwe nubusembure bwayo bituma iba ibintu byinshi.

Inganda zo kwisiga:

Mu nganda zo kwisiga, hydroxypropylcellulose ikoreshwa mugutegura ibicuruzwa byita kumisatsi, amavuta yuruhu nibindi bicuruzwa byita kumuntu. Imiterere ya firime ikora ifite agaciro mubicuruzwa byita kumisatsi.

3. Inganda zibiribwa:

Mu nganda zibiribwa, hydroxypropylcellulose ikoreshwa nkibintu byongera umubyimba. Biboneka mu biribwa bitandukanye kandi bifasha kunoza imiterere no gutuza.

Synthesis ya hydroxypropylcellulose ikubiyemo etherification ya selile wongeyeho amatsinda ya hydroxypropyl. Igisubizo mubisanzwe gitangizwa nifatizo, hagakurikiraho intambwe yo kweza kugirango ubone ibicuruzwa byiza cyane. Umusaruro winganda urashobora gukorwa nitsinda cyangwa inzira ikomeza hamwe ningamba zikomeye zo kugenzura ubuziranenge. Hydroxypropylcellulose ifite uburyo bwinshi bwo gukoresha mu nganda zimiti, amavuta yo kwisiga n’ibiribwa kubera imiterere yihariye kandi itandukanye. Gukomeza kunoza imikorere yumusaruro no guteza imbere porogaramu nshya byibanda kuri