Nigute ubwiza bwibisubizo byamazi ya HPMC bihinduka hamwe nibitekerezo?

Hydroxypropyl Methylcellulose (HPMC) ni selile yahinduwe ya selile ikoreshwa cyane mugutegura imiti, inyongeramusaruro, ibikoresho byubaka, kwisiga nizindi nzego. HPMC ifite umubyimba, gukora firime, gufatira hamwe nibindi bintu. Isano iri hagati yubusembwa hamwe nubushakashatsi bwibisubizo byamazi bifite akamaro kanini mubikorwa bitandukanye.

Ibiranga Viscosity biranga igisubizo cyamazi ya HPMC

Ibiranga shingiro
HPMC ikora igisubizo kibonerana cyangwa cyoroshye nyuma yo gushonga mumazi. Ubukonje bwabwo ntibwatewe gusa nubushakashatsi bwa HPMC gusa, ahubwo binagira ingaruka nkuburemere bwa molekile, ubwoko bwimbaraga nubushyuhe bwibisubizo.

Uburemere bwa molekuline: Nuburemere bwa molekuline ya HPMC, niko igisubizo kiboneka neza. Ni ukubera ko macromolecules ikora ibintu bigoye cyane byubatswe mubisubizo, byongera ubushyamirane hagati ya molekile.
Ubwoko busimburana: Ikigereranyo cyimikorere ya hydroxypropoxy na hydroxypropoxy bigira ingaruka kumyuka no kwiyegeranya kwa HPMC. Mubisanzwe, iyo methoxy yibiri hejuru, solubility ya HPMC iba nziza kandi viscosity yumuti nayo iba myinshi.

Isano iri hagati yo kwibanda hamwe no kwiyegeranya

Icyiciro cyo gukemura:
Iyo kwibumbira hamwe kwa HPMC ari muke, imikoranire hagati ya molekile iba idakomeye kandi igisubizo kigaragaza imiterere ya fluid ya Newtonian, ni ukuvuga ko ubwiza bwigenga ahanini butagendeye ku gipimo cyogosha.
Kuri iki cyiciro, ubwiza bwigisubizo bwiyongera kumurongo hamwe no kongera ibitekerezo. Iyi mibanire yumurongo irashobora kugaragazwa nuburinganire bworoshye bwo kugereranya:

Birashobora kugaragara mubyatanzwe ko ubwiza bwumuti wamazi wa HPMC bwiyongera cyane hamwe no kwiyongera kwibitekerezo. Iri terambere rizagaragara ku gishushanyo nkizamuka ryikurikiranya, cyane cyane mubice byibanda cyane.

Impamvu
Ingaruka yubushyuhe
Ubushyuhe bugira ingaruka zikomeye kumyumvire yumuti wa HPMC. Muri rusange, ubwiyongere bwubushyuhe bugabanya ubukonje bwumuti. Ni ukubera ko ubushyuhe bwiyongereye butera kwiyongera kwa molekile kandi bigabanya imikoranire hagati yiminyururu ya molekile, bityo bikagabanya ubukonje.

Ingaruka yikigereranyo
Kubisubizo byibanze bya HPMC, viscosity nayo igira ingaruka kubipimo byogosha. Ku gipimo kinini cyogosha, icyerekezo cyiminyururu ya molekile kiba gihamye kandi guterana imbere kugabanuka, bikavamo ubukonje buke bugaragara bwumuti. Iyi phenomenon yitwa shear thinning.

Porogaramu
Mu myiteguro ya farumasi, HPMC ikunze gukoreshwa mububiko bwa tablet, impapuro zirekura-zirekura, hamwe nubunini. Gusobanukirwa uburyo ubwiza bwibisubizo byamazi ya HPMC bihinduka hamwe nibitekerezo ningirakamaro mugutegura imiti ikwiye. Kurugero, mugutwikiriye ibinini, kwibanda kwa HPMC birashobora kwemeza ko amazi yatwikiriye afite ububobere buhagije bwo gupfukirana ibinini, mugihe atari hejuru cyane kuburyo bigoye kubyitwaramo.

Mu nganda zibiribwa, HPMC ikoreshwa nkibyimbye kandi bigahinduka. Gusobanukirwa isano iri hagati yo kwibanda hamwe no kwiyegeranya birashobora gufasha kumenya uburyo bwiza bwo kwibanda kugirango umenye uburyohe bwibiryo.

Ubwiza bwibisubizo byamazi ya HPMC bifite aho bihurira nibyiza. Irerekana kwiyongera kumurongo murwego rwo gukemura no kwiyongera kugaragara cyane. Iyi viscosity iranga ningirakamaro mubikorwa bitandukanye byinganda, kandi gusobanukirwa no kugenzura impinduka zijimye za HPMC ningirakamaro cyane muburyo bwo kunoza imikorere no kuzamura ibicuruzwa.