Hydroxypropyl methylcellulose (HPMC) ni polymer ikoreshwa cyane mu gutegura imiti, ikoreshwa cyane mu kongera igihe cyo gusohora imiti. HPMC nigice cya sintetike ya selile ikomoka kumashanyarazi hamwe no gukora firime. Muguhindura uburemere bwa molekile, kwibanda, kwiyegeranya nibindi bintu bya HPMC, igipimo cyo kurekura ibiyobyabwenge kirashobora kugenzurwa neza, bityo bikagera no kurekura ibiyobyabwenge igihe kirekire kandi birambye.
1. Imiterere nuburyo bwo kurekura ibiyobyabwenge bya HPMC
HPMC ikorwa na hydroxypropyl na methoxy yo gusimbuza imiterere ya selile, kandi imiterere yimiti yayo itanga kubyimba neza no gukora firime. Iyo uhuye namazi, HPMC ihita ikuramo amazi ikabyimba kugirango ikore geli. Ishirwaho ryiki geli ni bumwe muburyo bwingenzi bwo kugenzura irekurwa ryibiyobyabwenge. Kubaho kwa geli bigabanya kwinjiza amazi muri matrike yibiyobyabwenge, kandi ikwirakwizwa ryibiyobyabwenge rikabuzwa na geli, bityo bikadindiza umuvuduko wo kurekura ibiyobyabwenge.
2. Uruhare rwa HPMC mukwitegura-kurekura
Mu myiteguro irambye-irekura, HPMC isanzwe ikoreshwa nka matrix igenzurwa-irekura. Umuti uratatana cyangwa ushonga muri matrike ya HPMC, kandi iyo uhuye na fluid gastrointestinal fluid, HPMC irabyimba ikora geli. Igihe kirengana, geli igenda yiyongera buhoro buhoro, ikora inzitizi yumubiri. Umuti ugomba kurekurwa muburyo bwo hanze binyuze mu gukwirakwiza cyangwa isuri ya matrix. Uburyo bwibikorwa bukubiyemo ahanini ibintu bibiri bikurikira:
Uburyo bwo kubyimba: HPMC imaze guhura namazi, igice cyo hejuru gikurura amazi kandi kikabyimba kugirango kibe geli ya viscoelastic. Uko ibihe bigenda bisimburana, geli igenda yiyongera buhoro buhoro imbere, igice cyo hanze kirabyimba kandi kirashonga, kandi imbere imbere ikomeza gukora geli nshya. Ubu buryo bukomeza kubyimba na gel bigenzura igipimo cyo kurekura imiti.
Uburyo bwa Diffusion: Gukwirakwiza ibiyobyabwenge binyuze muri gel ni ubundi buryo bwingenzi bwo kugenzura igipimo cyo kurekura. Gele ya HPMC ikora nk'inzitizi yo gukwirakwiza, kandi ibiyobyabwenge bigomba kunyura muri iki cyiciro kugirango bigere muri vitro. Uburemere bwa molekile, ubukonje hamwe nubunini bwa HPMC mugutegura bizagira ingaruka kumiterere ya geli, bityo bigabanye igipimo cyo gukwirakwiza ibiyobyabwenge.
3. Ibintu bigira ingaruka kuri HPMC
Hariho ibintu byinshi bigira ingaruka kumikorere ya HPMC igenzurwa, harimo uburemere bwa molekile, ubukonje, urugero rwa HPMC, imiterere yumubiri nubumara yibiyobyabwenge, nibidukikije (nka pH nimbaraga za ionic).
Uburemere bwa molekuline hamwe nubwiza bwa HPMC: Nuburemere bwa molekuline ya HPMC, niko ubukonje bwurwego rwa gel bugenda buhoro kandi umuvuduko wo kurekura ibiyobyabwenge. HPMC ifite ubukonje bwinshi irashobora gukora geli ikaze, bikabuza umuvuduko wo gukwirakwiza ibiyobyabwenge, bityo bikongerera igihe cyo gusohora ibiyobyabwenge. Kubwibyo, mugushushanya imyiteguro irambye-irekura, HPMC ifite uburemere butandukanye bwa molekuline hamwe na viscosities akenshi byatoranijwe ukurikije ibikenewe kugirango bigerweho ingaruka ziteganijwe.
Kwishyira hamwe kwa HPMC: Ubwinshi bwa HPMC nabwo ni ikintu gikomeye mu kugenzura igipimo cy’ibiyobyabwenge. Ubunini bwa HPMC, niko umubyimba wa gel ugenda urushaho kwiyongera, niko kurwanya imiti ikwirakwizwa na geli, kandi umuvuduko wo kurekura ukagenda. Muguhindura igipimo cya HPMC, igihe cyo kurekura imiti kirashobora kugenzurwa byoroshye.
Imiterere ya fiziki ya chimique yibiyobyabwenge: Ubushobozi bwamazi, uburemere bwa molekile, solubile, nibindi byibiyobyabwenge bizagira ingaruka kumyitwarire yayo muri matrike ya HPMC. Ku biyobyabwenge bifite amazi meza, imiti irashobora gushonga mumazi vuba kandi igakwirakwira mugice cya gel, bityo igipimo cyo kurekura cyihuta. Ku biyobyabwenge bifite amazi mabi, ibishishwa ni bike, ibiyobyabwenge bigenda bikwirakwira gahoro gahoro, kandi igihe cyo kurekura ni kirekire.
Ingaruka yibidukikije byo hanze: Imiterere ya gel ya HPMC irashobora kuba itandukanye mubidukikije bifite agaciro ka pH bitandukanye nimbaraga za ionic. HPMC irashobora kwerekana imyitwarire itandukanye yo kubyimba mubidukikije bya acide, bityo bikagira ingaruka kumubare wibiyobyabwenge. Bitewe n’imihindagurikire nini ya pH mu nzira ya gastrointestinal yumuntu, imyitwarire ya matrix ya HPMC ihoraho-irekura-mubihe bitandukanye bya pH bisaba kwitabwaho byumwihariko kugirango ibiyobyabwenge bisohore neza kandi bikomeje.
4. Gushyira mu bikorwa HPMC muburyo butandukanye bwo kugenzura-kurekura imyiteguro
HPMC ikoreshwa cyane mugutegura-kurekura imyiteguro yuburyo butandukanye nka tableti, capsules, na granules. Mu bisate, HPMC nk'ibikoresho bya matrix irashobora gukora imiti ivanze na polymer imwe hanyuma ikarekura buhoro buhoro imiti mu nzira ya gastrointestinal. Muri capsules, HPMC nayo ikoreshwa kenshi nka membrane igenzurwa-kurekura ibice by ibiyobyabwenge, kandi igihe cyo kurekura imiti igenzurwa no guhindura umubyimba nubukonje bwurwego.
Gukoresha ibinini: Ibinini nuburyo bukoreshwa cyane mu kanwa, kandi HPMC ikoreshwa muburyo bwo kurekura ibiyobyabwenge. HPMC irashobora kuvangwa nibiyobyabwenge hanyuma igahagarikwa kugirango igire sisitemu imwe itatanye. Iyo tablet yinjiye mu nzira ya gastrointestinal, hejuru ya HPMC irabyimba vuba kandi ikora gel, igabanya umuvuduko wo gusesa ibiyobyabwenge. Muri icyo gihe, uko geli ikomeza kwiyongera, irekurwa ry'imiti y'imbere rigenzurwa buhoro buhoro.
Gusaba muri capsules:
Mu myiteguro ya capsule, HPMC isanzwe ikoreshwa nkigenzura rirekuwe. Muguhindura ibiri muri HPMC muri capsule hamwe nubunini bwa firime ya coating, igipimo cyo gusohora imiti kirashobora kugenzurwa. Byongeye kandi, HPMC ifite imbaraga zo gukemura no guhuza ibinyabuzima mu mazi, bityo ikaba ifite amahirwe menshi yo gukoresha muri capsule igenzurwa na sisitemu yo kurekura.
5. Iterambere ry'ejo hazaza
Hamwe n’iterambere ry’ikoranabuhanga mu bya farumasi, ikoreshwa rya HPMC ntirigarukira gusa ku myiteguro irekura-irekuwe gusa, ahubwo rishobora no guhuzwa n’ubundi buryo bushya bwo gutanga imiti, nka microsperes, nanoparticles, n’ibindi, kugira ngo ibiyobyabwenge bishoboke. Byongeye kandi, mugukomeza guhindura imiterere ya HPMC, nko kuvanga nizindi polymers, guhindura imiti, nibindi, imikorere yayo mugutegura-kurekura irashobora kurushaho kunozwa.
HPMC irashobora kongera igihe cyo kurekura ibiyobyabwenge binyuze muburyo bwayo bwo kubyimba kugirango ikore geli. Ibintu nkuburemere bwa molekile, ubukonje, kwibumbira hamwe kwa HPMC hamwe nubuvuzi bwa fiziki bwa chimique yibiyobyabwenge bizagira ingaruka kumikorere yabyo. Mubikorwa bifatika, mugushushanya neza imikoreshereze ya HPMC, kurekura byimazeyo imiti itandukanye irashobora kugerwaho kugirango ivure ibikenewe mubuvuzi. Mu bihe biri imbere, HPMC ifite amahirwe menshi yo gukoreshwa mu rwego rwo kurekura ibiyobyabwenge ku buryo burambye, kandi irashobora guhuzwa n’ikoranabuhanga rishya kugira ngo irusheho guteza imbere uburyo bwo gutanga ibiyobyabwenge.
Igihe cyo kohereza: Nzeri-19-2024