Hydroxyethyl Cellulose (HEC) hamwe na ethers ya selile (nka hydroxypropyl methylcellulose (HPMC), methylcellulose (MC), hydroxypropyl selulose (HPC) na carboxymethyl selulose (CMC) ni polymers ikora cyane mubikorwa byinganda, ubwubatsi, ubuvuzi, ibiryo na burimunsi. inganda zikora imiti. Izi nkomoko ya selile ikorwa muguhindura selile kandi ikagira amazi meza, kubyimba, gutuza no gukora firime.
1. Hydroxyethyl Cellulose (HEC)
1.1 Imiterere yimiti nibyiza
Hydroxyethyl Cellulose (HEC) ikorwa na hydroxyethylation ya selile hamwe na okiside ya Ethylene mubihe bya alkaline. Imiterere yibanze ya HEC ni ether ihuza iterwa no gusimbuza itsinda rya hydroxyl muri molekile ya selile na hydroxyethyl. Iyi miterere iha HEC ibintu byihariye:
Amazi meza: HEC irashonga mumazi akonje kandi ashyushye kugirango ikore igisubizo kiboneye.
Kubyimba: HEC ifite imiterere myiza yo kubyimba kandi ikoreshwa cyane mubisabwa bisaba kugenzura ububobere.
Igihagararo: Igisubizo cya HEC gifite ituze ryinshi mubice bitandukanye bya pH.
Biocompatibilité: HEC ntabwo ari uburozi, ntibitera uburakari, kandi ni urugwiro kumubiri wumuntu nibidukikije.
1.2 Imirima yo gusaba
Ibikoresho byo kubaka: bikoreshwa nkibikoresho byongera amazi bigumana amazi ya sima na gypsumu.
Kwambika amarangi: gukoreshwa nkibibyimbye, guhagarika agent na stabilisateur.
Imiti ya buri munsi: ikoreshwa nkibibyibushye mubikenerwa bya buri munsi nka detergent na shampo.
Imiti ya farumasi: ikoreshwa nkibikoresho bifata, byongera umubyimba kandi uhagarika ibinini byibiyobyabwenge.
1.3 Ibyiza n'ibibi
Ibyiza: gukomera kwamazi meza, gutuza imiti, kwaguka kwa pH kwinshi no kutagira uburozi.
Ibibi: gukemura nabi mumashanyarazi amwe, kandi igiciro gishobora kuba hejuru gato ugereranije nizindi selile.
2. Kugereranya izindi ethers ya selile
2.1 Hydroxypropyl methylcellulose (HPMC)
2.1.1 Imiterere yimiti nimiterere
HPMC ikozwe muri selile ikoresheje methylation na hydroxypropylation reaction. Imiterere yarwo ikubiyemo imikorere yombi (-OCH3) na hydroxypropoxy (-OCH2CH (OH) CH3).
Amazi meza: HPMC ishonga mumazi akonje kugirango ikore igisubizo kiboneye; ifite ubushobozi buke mu mazi ashyushye.
Kubyimba imitungo: Ifite ubushobozi buhebuje.
Imiterere ya Gelling: Ikora gel iyo ishyushye igasubira muburyo bwayo iyo ikonje.
2.1.2
Ibikoresho byo kubaka: Ikoreshwa nkibikoresho binini kandi bigumana amazi kubikoresho bya sima na gypsumu.
Ibiryo: Ikoreshwa nka emulisiferi na stabilisateur.
Ubuvuzi: Ikoreshwa nkibikoresho bya farumasi ya capsules na tableti.
2.1.3 Ibyiza n'ibibi
Ibyiza: Imikorere myiza yo kubyimba hamwe na gelling.
Ibibi: Yumva ubushyuhe kandi irashobora kunanirwa mubushyuhe bwo hejuru.
2.2 Methyl selulose (MC)
2.2.1 Imiterere yimiti nimiterere
MC iboneka na methylation ya selile kandi ahanini irimo insimburangingo (-OCH3).
Amazi meza: ashonga neza mumazi akonje kugirango akore igisubizo kiboneye.
Kubyimba: bifite ingaruka zikomeye zo kubyimba.
Ubushyuhe bwa Thermal: bukora gel iyo ishyushye na degels iyo ikonje.
2.2.2
Ibikoresho byo kubaka: bikoreshwa nkibyimbye kandi bigumana amazi ya minisiteri no gusiga irangi.
Ibiryo: bikoreshwa nka emulifier na stabilisateur.
2.2.3 Ibyiza n'ibibi
Ibyiza: imbaraga zikomeye zo kubyimba, zikoreshwa kenshi muburyo bwo gutunganya imbeho.
Ingaruka: ubushyuhe-bworoshye, ntibushobora gukoreshwa mubushyuhe bwinshi.
2.3 Hydroxypropyl selile (HPC)
2.3.1 Imiterere yimiti nimiterere
HPC iboneka na hydroxypropyl selile. Imiterere yacyo irimo hydroxypropoxy (-OCH2CH (OH) CH3).
Amazi meza: ashonga mumazi akonje hamwe na solge organic.
Kubyimba: imikorere myiza yo kubyimba.
Umutungo ukora firime: ukora firime ikomeye.
2.3.2
Ubuvuzi: bukoreshwa nkibikoresho byo gutwikira hamwe na tableti ikoreshwa kubiyobyabwenge.
Ibiryo: bikoreshwa nkibyimbye na stabilisateur.
2.3.3 Ibyiza n'ibibi
Ibyiza: gukemura ibibazo byinshi hamwe nibintu byiza byo gukora firime.
Ibibi: igiciro kinini.
2.4 Carboxymethyl selulose (CMC)
2.4.1 Imiterere yimiti nibiranga
CMC ikorwa mugukora selile hamwe na aside ya chloroacetike, kandi ikubiyemo itsinda rya carboxymethyl (-CH2COOH) muburyo bwayo.
Amazi meza: gushonga mumazi akonje namazi ashyushye.
Umubyibuho ukabije: ingaruka zikomeye zo kubyimba.
Ionicity: ni ya anionic selulose ether.
2.4.2
Ibiryo: bikoreshwa nkibyimbye na stabilisateur.
Imiti ya buri munsi: ikoreshwa nkibyimbye kumashanyarazi.
Gukora impapuro: bikoreshwa nk'inyongera mu gutwikira impapuro.
2.4.3 Ibyiza n'ibibi
Ibyiza: kubyimba neza no kwagura imirima.
Ibibi: byunvikana kuri electrolytite, ion mubisubizo birashobora kugira ingaruka kumikorere.
3. Kugereranya muri rusange
3.1 Imikorere yibyibushye
HEC na HPMC bifite imikorere isa niyongera kandi byombi bigira ingaruka nziza. Nyamara, HEC ifite amazi meza kandi ikwiranye nibisabwa bisaba gukorera mu mucyo no kurakara gake. HPMC ni ingirakamaro cyane mubisabwa bisaba gushyushya gel kubera imiterere ya thermogel.
3.2 Amazi meza
HEC na CMC byombi bishobora gushonga mumazi akonje kandi ashyushye, mugihe HPMC na MC bishonga cyane mumazi akonje. HPC ihitamo iyo guhuza byinshi-bisabwa.
3.3 Igiciro hamwe nurwego rwo gusaba
HEC isanzwe igiciro gito kandi ikoreshwa cyane. Nubwo HPC ifite imikorere myiza, mubisanzwe ikoreshwa mubisabwa cyane kubera igiciro cyayo kinini. CMC ifite umwanya mubikorwa byinshi bidahenze hamwe nigiciro cyayo gito kandi ikora neza.
Hydroxyethyl selulose (HEC) ibaye imwe muri ethers ya selile ikoreshwa cyane kubera amazi meza yo gukomera, gutuza hamwe nubushobozi bwo kubyimba. Ugereranije nizindi selile ya selulose, HEC ifite ibyiza bimwe na bimwe byo gukemura amazi no gutuza imiti, kandi irakwiriye kubisabwa bisaba ibisubizo biboneye kandi bigahuzwa na pH. HPMC yitwaye neza mubice bimwe na bimwe bitewe nubushyuhe bwayo nubushyuhe bwo gutwika amashyuza, mugihe HPC na CMC zifite umwanya wingenzi mubikorwa byabo bitewe nuburyo bwo gukora firime nibyiza byo kugura. Ukurikije ibisabwa byihariye bisabwa, guhitamo selile nziza ya ether irashobora guhindura imikorere yibicuruzwa no gukora neza.
Igihe cyo kohereza: Nyakanga-10-2024