Hydroxypropyl methylcellulose (HPMC), izwi kandi nka hypromellose, ni polymer itandukanye ikoreshwa mu nganda zitandukanye zirimo imiti, ibiryo, n'ubwubatsi. Nibikomoka kuri selile byahinduwe binyuze mumiti kugirango yongere imiterere yayo. Iyi polymer irangwa no gukemura amazi, ibinyabuzima, hamwe nubushobozi bwo gukora firime.
Imiterere yimiti ya hydroxypropyl methylcellulose (HPMC):
Hydroxypropyl methylcellulose ikomoka kuri selile, polyisikaride karemano iboneka murukuta rw'utugingo ngengabuzima. Imiterere yimiti ya HPMC irangwa no kuba hydroxypropyl na methyl groupe ya selile ya rugongo.
Umugongo wa selile:
Cellulose ni umurongo wa polysaccharide ugizwe na glucose igizwe na β-1,4-glycosidic. Ibice bisubiramo bikora iminyururu ndende, ikomeye itanga ishingiro ryimiterere ya HPMC.
methyl:
Amatsinda ya Methyl (CH3) yinjizwa mumugongo wa selile binyuze mumiti ya methanol. Uku gusimbuza kuzamura hydrophobicity ya polymer, bigira ingaruka kumikorere no gukora firime.
Hydroxypropyl:
Amatsinda ya Hydroxypropyl (C3H6O) afatanye numugongo wa selile ukoresheje reaction ya okiside ya propylene. Aya matsinda ya hydroxypropyl agira uruhare mu gukemura amazi ya HPMC kandi akagira ingaruka ku bwiza bwayo.
Urwego rwo gusimbuza (DS) rwamatsinda ya methyl na hydroxypropyl rushobora gutandukana, bigira ingaruka kumikorere rusange ya HPMC. DS bivuga impuzandengo y'ibisimburwa kuri glucose igice mumurongo wa selile.
Synthesis ya Hydroxypropyl Methylcellulose (HPMC):
Synthesis ya HPMC ikubiyemo intambwe nyinshi zimiti itangiza methyl na hydroxypropyl mumatsinda ya selile. Ibisubizo byingenzi birimo etherification hamwe na methyl chloride na hydroxypropylation hamwe na oxyde ya propylene. Dore incamake yoroshye:
Gukora selile:
Inzira itangirana no gukora selile ukoresheje base, mubisanzwe hydroxide ya sodium. Iyi ntambwe yongerera imbaraga za selile hydroxyl ya selile ya reaction nyuma.
Methylation:
Methyl chloride ikoreshwa mugutangiza amatsinda ya methyl. Cellulose ifata methyl chloride imbere ya base, bikavamo gusimbuza amatsinda ya hydroxyl hamwe na methyl.
reaction:
Cellulose-OH + CH3Cl → Cellulose-OMe + Cellulose Hydrochloride-OH + CH3Cl → Cellulose-OMe + HCl
Hydroxypropylation:
Amatsinda ya Hydroxypropyl yometse kumugongo wa selile ukoresheje okiside ya propylene. Ubusanzwe reaction ibera murwego rwa alkaline kandi urwego rwa hydroxypropylation rugenzurwa kugirango ugere kubintu byifuzwa.
reaction:
Cellulose-OH + C3H6 ogisijeni → Cellulose-O- (CH2CH (OH) CH3) + H2 ogisijeni Cellulose-OH + C3H6O → Cellulose-O- (CH2CH (OH) CH3) + H2 ogisijeni
Kutabogama no kwezwa:
Ibicuruzwa bivamo bidafite aho bibogamiye kugirango bikureho ibisigisigi byose bisigaye cyangwa ibanze. Intambwe zo kweza nko gukaraba no kuyungurura bikorwa kugirango ubone ibicuruzwa byiza bya HPMC.
Ibikoresho bya shimi bya Hydroxypropyl Methylcellulose (HPMC):
Gukemura:
HPMC irashobora gushonga byoroshye mumazi akonje, kandi ibisubizo birashobora guhinduka muguhindura urwego rwo gusimburwa. Urwego rwo hejuru rwo gusimbuza rusanzwe rutera kwiyongera.
Gushinga firime:
HPMC ifite imiterere myiza yo gukora firime, ituma ikoreshwa nkibikoresho bya farumasi no gupakira ibiryo. Filime yavuyemo iragaragara kandi itanga inzitizi ya gaze.
Ubushyuhe bwa Thermal:
Ubushyuhe bwa Thermal ni umutungo wihariye wa HPMC. Gele ikora iyo ishyushye, kandi imbaraga za gel ziterwa nibintu nko kwibanda hamwe nuburemere bwa molekile.
Viscosity:
Ubukonje bwibisubizo bya HPMC bigira ingaruka kurwego rwo gusimbuza no kwibanda. Nkibyimbye, ikoreshwa cyane mubikorwa bitandukanye.
Igikorwa cyo hejuru:
HPMC ifite ibintu bisa nkibintu bigira uruhare mu kwigana no gutezimbere ubushobozi.
Biocompatibilité:
HPMC ifatwa nkibinyabuzima, bigatuma ikoreshwa mu miti y’imiti, harimo n’imiti igenzurwa-irekurwa.
Porogaramu ya Hydroxypropyl Methylcellulose (HPMC):
ibiyobyabwenge:
HPMC isanzwe ikoreshwa nka binders, coating firime, hamwe na matrices yo kurekura mugukoresha imiti.
shyira:
Mu nganda zubaka, HPMC ikoreshwa nkibikoresho bigumana amazi mu bikoresho bishingiye kuri sima, kunoza imikorere no kugabanya gutandukanya amazi.
inganda z'ibiribwa:
HPMC ikoreshwa mu nganda zibiribwa nkibyimbye, stabilisateur na gelling agent. Bikunze gukoreshwa mubicuruzwa nka sosi, isupu na ice cream.
Ibicuruzwa byita ku muntu:
Amavuta yo kwisiga hamwe ninganda zita kumuntu Koresha HPMC ikoreshwa mubicuruzwa nka cream n'amavuta yo kwisiga kubera kubyimbye no kumera.
Irangi hamwe n'ibifuniko:
HPMC yongewe kumarangi no gutwikira kugirango yongere ubwiza, ituze hamwe no gufata amazi.
mu gusoza:
Hydroxypropyl methylcellulose ni polymer itandukanye kandi ifite uburyo bwinshi bwo gukoresha kubera imiterere yihariye ya shimi. Synthesis ya HPMC ikubiyemo kwinjiza amatsinda ya methyl na hydroxypropyl mumugongo wa selile, bikavamo amazi-elegitoronike na polymer biocompatible polymer. Uburyo butandukanye bukoreshwa muri farumasi, ubwubatsi, ibiryo no kwita kumuntu kugaragaza akamaro kayo mubikorwa bitandukanye. Mugihe ubushakashatsi bukomeje, ibindi byahinduwe niterambere mu ikoranabuhanga rya HPMC birashobora kwagura ibikorwa byacyo no kuzamura imikorere yabyo biriho kandi bigenda bigaragara.
Igihe cyo kohereza: Ukuboza-18-2023