Kubera ko isi igenda yiyongera ku bijyanye no kurengera ibidukikije ndetse no gusaba iterambere rirambye, uruganda rukora imiti rurimo gushakisha ibisubizo byangiza ibidukikije kandi birambye. Intungamubiri za selulose ether zigenda ziba kimwe mubikoresho byingenzi bigamije guteza imbere iterambere rirambye ryinganda zimiti kubera umutungo kamere ushobora kuvugururwa nibiranga ibinyabuzima.
1. Incamake yibanze ya Cellulose Ethers
Ether ya selile ni ibikoresho bya polymer byabonetse muguhindura imiti ya selile naturel. Cellulose iboneka cyane mu bimera, nk'ipamba n'ibiti. Intangiriro yacyo ni urunigi rwa polysaccharide rwakozwe na glucose ibice bihujwe na β-1,4-glycosidic. Binyuze muri reaction ya etherification, amatsinda ya hydroxyl ya selile ahujwe nubwoko butandukanye bwamatsinda ya ether kugirango habeho urukurikirane rwibikomoka kuri selile, nka hydroxypropyl methylcellulose (HPMC), methyl selulose (MC) na hydroxyethyl selulose (HEC). Ibikomoka kuri selulose ether bifite firime nziza cyane, ifata neza, ikabyimbye hamwe nubushyuhe bwumuriro, kandi ikoreshwa cyane mumiti yimiti, ubwubatsi, ibiryo, kwisiga nizindi nganda.
2. Gushyira mu bikorwa ibikomoka kuri selulose ether mu nganda zimiti
Abatwara ibiyobyabwenge hamwe na sisitemu ihoraho-irekura
Bumwe mu buryo bukoreshwa cyane muri selile ya ether ikomoka mu miti ya farumasi ni nk'itwara kandi ikomeza kurekura imiti. Binyuze mu gukora firime no gufatira hamwe, ether ya selile irashobora gukoreshwa mugutegura ibinini bya farumasi, capsules na firime. By'umwihariko, muri sisitemu irekura-irekuye, ibikomoka kuri selile nka HPMC birashobora gukora geli nyuma ya hydrata, ikarekura buhoro buhoro ibiyigize ibiyobyabwenge, kandi bigatuma ibiyobyabwenge byinjira buhoro buhoro. Ubu buryo burambye bwo kurekura ntibushobora guteza imbere ibiyobyabwenge gusa, ariko kandi bigabanya inshuro nyinshi imiti kandi bigabanya umutwaro abarwayi.
Ibikoresho bya tablet na disintegrants
Mu musaruro wa tablet, ibikomoka kuri selulose ether nabyo bikoreshwa cyane nka binders na disintegrants. Nka binder, selulose ether irashobora kongera imbaraga zihuza hagati yifu yifu mugihe ibinini byifunitse, byemeza imbaraga nibihamye byibinini; nk'ibidahwitse, irashobora kwinjiza vuba amazi ikabyimba nyuma yo guhura n'amazi, bigatuma ibinini bikwirakwira vuba kandi bigashonga muri sisitemu y'ibiryo, bityo bikongera umuvuduko wo kurekura no gufata neza imiti.
Imyiteguro y'ababyeyi
Inkomoko ya selulose ether nayo ikoreshwa mugutegura imyiteguro yababyeyi, nkibikoresho bigenzura ibibyimba hamwe na stabilisateur mumiti yinjira. Imiterere yihariye yumubiri nubumashini ituma ihagarara nyuma yubushyuhe bwo hejuru butagize ingaruka kumikorere yibinyabuzima yibiyobyabwenge. Muri icyo gihe, kutagira uburozi na biocompatibilité ya selile ya selile nayo itanga umutekano mu mubiri.
3. Umusanzu wibikomoka kuri selulose ether mukuramba kwinganda zimiti
Bikomoka ku mutungo kamere, ushobora kuvugururwa
Inyungu igaragara yibikomoka kuri selile ni uko bikomoka ku mutungo kamere ushobora kuvugururwa nka pamba ninkwi. Ibi bitandukanye cyane na polimeri gakondo (nka polyethylene, polypropilene, nibindi). Ibikoresho bya sintetike gakondo akenshi bishingiye kubicuruzwa bya peteroli, biganisha ku gukoresha cyane umutungo udashobora kuvugururwa nibibazo byangiza ibidukikije. Ibinyuranye, selile, nk'ibikoresho bishingiye kuri bio, irashobora guhora itangwa binyuze mukuzamuka kw'ibimera, bikagabanya gushingira ku mutungo wa peteroli.
Ibinyabuzima bishobora kwangirika, kugabanya umwanda w’ibidukikije
Iyindi nyungu nyamukuru ya selulose ether ikomokaho nuko bafite ibinyabuzima byiza. Bitandukanye na plastiki gakondo nibikoresho bya sintetike, ether ya selile irashobora kwangirika na mikorobe mu bidukikije kandi amaherezo ikabyara ibintu bitagira ingaruka nkamazi na dioxyde de carbone. Ibi bigabanya cyane ingaruka mbi z’imyanda ku bidukikije mugihe cyo gukora imiti kandi bigafasha kugabanya umwanda wubutaka n’amazi n’imyanda ikomeye.
Kuzigama ingufu no kugabanya ibyuka bihumanya
Igikorwa cyo gukora ethers ya selile kiri hasi cyane mugukoresha ingufu, kandi guhindura imiti no kuyitunganya birashobora kugerwaho mubushyuhe buke, ibyo bikaba bitandukanye cyane nuburyo bukoreshwa ningufu nyinshi zikoreshwa na polimeri zimwe na zimwe. Muri icyo gihe, kubera ibintu byoroheje biranga ibikoresho bishingiye kuri selile, birashobora kandi kugabanya gukoresha ingufu n’ibyuka bihumanya ikirere mu gihe cyo gutwara no gupakira.
Amahame ya Chimie yicyatsi
Synthesis ya selulose ether ikomokaho irashobora gukurikiza amahame ya chimie yicyatsi kibisi, ni ukuvuga mukugabanya ikoreshwa ryimiti yangiza imiti no guhindura uburyo bwo kubyitwaramo kugirango igabanye umusaruro wibicuruzwa, bityo bigabanye ingaruka kubidukikije. Kurugero, uburyo bwo gutanga umusaruro wa selile ya kijyambere ya selile yakoresheje uburyo bwangiza ibidukikije hamwe n’ibikoresho byangiza ibidukikije, byagabanije cyane imyuka y’ubumara.
4. Ibihe bizaza
Hamwe niterambere rihoraho ryimiti yimiti yicyatsi, ibyifuzo byo gukoresha selulose ether ikomoka mubikorwa bya farumasi bizaba binini. Usibye kuyishyira mu bikorwa mu myiteguro ihamye hamwe na sisitemu irekura-irekura, ethers ya selile nayo izagira uruhare runini muri sisitemu nshya yo gutanga ibiyobyabwenge, ibikoresho by’ubuvuzi n’ibindi bice. Byongeye kandi, hamwe nogukomeza gutera imbere kwikoranabuhanga rya selile ikomoka kuri selile, iterambere ryuburyo bunoze kandi buhendutse bwo gutegura ibiciro bizarushaho guteza imbere kwamamara munganda zimiti.
Uruganda rwa farumasi ruzita cyane ku gushyira mu bikorwa ibikoresho bitangiza ibidukikije, hamwe n’ibikomoka kuri selulose ether, nkibikoresho bishobora kuvugururwa, byangirika kandi bikora byinshi, nta gushidikanya ko bizagira uruhare runini muri iyi nzira yo guhindura.
Inkomoko ya selulose ether yazamuye cyane iterambere ryimiti yimiti binyuze muburyo bushya, ibinyabuzima byangiza kandi bigakoreshwa mugukora imiti. Ntibagabanya gusa gushingira ku mutungo udasubirwaho, ahubwo banatanga umusanzu wingenzi mukurengera ibidukikije. Ibikomoka kuri selulose ether biteganijwe ko bizakomeza kugira uruhare runini mugihe kizaza cy’inganda zikora imiti n’iterambere rirambye.
Igihe cyo kohereza: Nzeri-23-2024