HPC na HPMC birasa?

HPC (Hydroxypropyl Cellulose) na HPMC (Hydroxypropyl Methylcellulose) ni ibintu bibiri bikomoka ku mazi ya selile yamashanyarazi akoreshwa cyane mu nganda zimiti, ibiribwa n’imiti. Nubwo bisa mubice bimwe, imiterere yimiti, imiterere nibisabwa biratandukanye cyane.

1. Imiterere yimiti
HPC: HPC ni hydroxypropylated igice gikomoka kuri selile. Yakozwe mugukora selile hamwe na oxyde ya propylene no kumenyekanisha amatsinda ya hydroxypropyl (-CH2CHOHCH3). Mu miterere ya HPC, igice cyamatsinda ya hydroxyl yumugongo wa selulose asimbuzwa amatsinda ya hydroxypropyl, bigatuma ashonga amazi na thermoplastique.
HPMC: HPMC ni hydroxypropylated igice na methylated ikomoka kuri selile. Itegurwa no kumenyekanisha amatsinda ya hydroxypropyl hamwe nitsinda ryimikorere (-OCH3) muri selile. Imiterere ya molekulire ya HPMC iraruhije, hamwe no gutangiza amatsinda ya hydroxypropyl hamwe na methyl.

2. Imiterere yumubiri nubumara
Gukemura: Byombi ni polimeri-ere-polymers, ariko imyitwarire yabo yo gusesa iratandukanye. HPC ifite imbaraga zo gukonjesha mumazi akonje hamwe na solge zimwe na zimwe (nka Ethanol, propanol, nibindi), ariko imbaraga zayo zishobora kugabanuka mubushyuhe bwinshi (hafi 45 ° C cyangwa hejuru). HPMC ifite imbaraga zidasanzwe mu mazi akonje, ariko ifite imiterere ya gell mumazi yubushyuhe bwo hejuru, ni ukuvuga ko ubushyuhe buri hejuru, HPMC yashonga mumazi izakora gel kandi ntizongera gushonga.
Ubushyuhe bwumuriro: HPC ifite thermoplastique nziza, bivuze ko ishobora koroshya cyangwa gushonga mubushyuhe bwinshi, bityo ikoreshwa kenshi mubikoresho byo kubumba. HPMC ifite ubushyuhe bwinshi, ntabwo byoroshye gushonga cyangwa koroshya, kandi birakwiriye gukoreshwa mugihe cy'ubushyuhe bwinshi.
Viscosity: Ubusanzwe HPMC ifite ubukonje burenze HPC, cyane cyane mu nganda zimiti, HPMC ikoreshwa kenshi mubisobanuro bisaba guhuza bikomeye cyangwa gutwikira, mugihe HPC ikoreshwa mubihe bikenewe ubukonje buciriritse cyangwa buke.

3. Imirima yo gusaba
Umwanya wa farumasi:
HPC: HPC ni imiti ikoreshwa cyane mu bya farumasi, ikoreshwa cyane cyane nk'ibikoresho bifata ibinini, ibikoresho bya capsule shell ikora, hamwe nibikoresho bya matrix byo kurekura ibiyobyabwenge. Bitewe na thermoplastique, biranakwiriye gutegurwa gushushe. HPC ifite kandi biocompatibilité nziza no kwangirika, kandi irakwiriye gukoreshwa nka sisitemu yo gutanga ibiyobyabwenge imbere.
HPMC: HPMC ikoreshwa cyane mu nganda zimiti, kandi akenshi ikoreshwa nkibikoresho bya matrix, ibikoresho byo gutwikira, kubyimbye hamwe na stabilisateur kugirango ibinini bisohora. Imiterere ya gelling ya HPMC ituma iba ibikoresho byiza byo kugenzura ibiyobyabwenge, cyane cyane mu gifu cya gastrointestinal, aho bishobora kugenzura neza igipimo cyo gusohora ibiyobyabwenge. Ibikoresho byiza byo gukora firime nabyo bituma ihitamo nyamukuru kububiko bwa tablet hamwe no gutwikira ibice.

Umurima w'ibiribwa:
HPC: Mu nganda zibiribwa, HPC irashobora gukoreshwa nkibyimbye, stabilisateur na emulisiferi kugirango itezimbere imiterere yimiterere yibiribwa. Rimwe na rimwe, irashobora kandi gukoreshwa nkibikoresho bya firime biribwa kubiribwa bimwe na bimwe bigomba guhora bitose cyangwa byitaruye.
HPMC: HPMC nayo ikoreshwa cyane mubyimbye, emulisiferi na stabilisateur mu nganda zibiribwa, cyane cyane mubicuruzwa bitetse nkumugati nudutsima. HPMC ifasha kunoza imiterere nuburyo bwimigati no kongera ubuzima bwibiryo. Byongeye kandi, HPMC ikoreshwa cyane mubiribwa bikomoka ku bimera nkibimera bishingiye ku bimera kugirango bisimbuze inyamaswa za kolagen.
Amavuta yo kwisiga n'ibicuruzwa byita ku muntu:

HPC na HPMC byombi birashobora gukoreshwa mu kwisiga nkibibyimbye, stabilisateur hamwe nabakora firime. Kurugero, zirashobora gukoreshwa mukwitaho uruhu nibicuruzwa byumusatsi kugirango bitezimbere gukoraho no gutuza kwibicuruzwa. Ubusanzwe HPMC irakwiriye cyane nka agent ya colloid ibonerana, nkibyimbye mumatonyanga y'amaso, mugihe HPC ikoreshwa mugihe hagomba kubaho igipande cyoroshye.
Ibikoresho byo kubaka no gutwikira:

HPMC: Bitewe no gufata neza no gufata amazi, HPMC ikoreshwa cyane mubikoresho byubaka nka sima, minisiteri, putty na gypsum kugirango byongere imbaraga kandi binoze imikorere yubwubatsi.
HPC: Ibinyuranye, HPC ntabwo ikoreshwa cyane mubikorwa byubwubatsi kandi ikoreshwa cyane nkinyongera cyangwa ifata imyenda.

4. Umutekano no kurengera ibidukikije
HPC na HPMC byombi bifatwa nkibikoresho bifite umutekano kandi bikoreshwa cyane mubiribwa, imiti n’ibicuruzwa byita ku muntu. Byombi bifite biocompatibilité nziza kandi byangirika, kandi ntibizatera ingaruka z'ubumara kumubiri wumuntu. Ariko, kubera ko zitinjiye mumubiri wumuntu kandi zikoreshwa gusa nkibikoresho byunganira, mubisanzwe ntabwo bigira ingaruka zifatika kumubiri wumuntu. Byongeye kandi, uburyo bwo gukora HPC na HPMC bwangiza ibidukikije, kandi imiti n’umuti ukoreshwa mu musaruro birashobora gukoreshwa neza kandi bigakoreshwa neza.

Nubwo HPC na HPMC byombi bikomoka kuri selile kandi bifite aho bihurira na porogaramu zimwe na zimwe, bifite itandukaniro rikomeye mumiterere yimiti, imiterere yumubiri hamwe n’ahantu hashyirwa. HPC irakwiriye cyane kubisabwa bisaba ibikoresho bya termoplastique, nko kurekura ibiyobyabwenge hamwe nuburyo bwo gushonga bishushe, mugihe HPMC ikoreshwa cyane mumiti yimiti, ibiryo, ubwubatsi nizindi nzego bitewe no gufatana neza kwayo, gukora firime no kubika amazi. . Kubwibyo, ibikoresho byo guhitamo biterwa nibisabwa byihariye bisabwa.