1. Ibintu shingiro bya HPMC
Hydroxypropyl methylcellulose, izina ry'icyongereza ni hydroxypropyl methylcellulose, izwi kandi nka HPMC. Inzira ya molekile yayo ni C8H15O8- (C10Hl8O6) N-C8HL5O8, kandi uburemere bwa molekile ni 86.000. Igicuruzwa ni kimwe cya kabiri, kigizwe na methyl igice na selile selile polyhydroxypropyl ether. Irashobora gukorwa muburyo bubiri: bumwe nukuvura urwego rukwiye rwa methyl selulose hamwe na NaOH, hanyuma ukitwara hamwe na oxyde ya propylene munsi yubushyuhe bwinshi numuvuduko mwinshi. Igihe cyo kubyitwaramo kigomba gukomeza kugirango amatsinda ya methyl na hydroxypropyl ahindurwe muri ethers. Ifishi irahari kandi ihujwe nimpeta ya glucose idafite umwuma wa selile kurwego rusabwa; ikindi ni ukuvura ipamba cyangwa ibiti bya pulp fibre hamwe na soda ya caustic kugirango ikore kugirango ibone methane chloride na okiside ya propylene, ishobora kurushaho kunonosorwa no hasi. Kora ifu nziza kandi imwe cyangwa granules. HPMC ni selile karemano ya selile kandi ikoreshwa neza na farumasi hamwe nisoko ryinshi. Kugeza ubu ikoreshwa cyane mu gihugu ndetse no hanze yarwo kandi ni kimwe mu bintu bikoresha imiti ikoreshwa cyane mu miti yo mu kanwa.
Ibicuruzwa byera kugeza amata yera, adafite uburozi, impumuro nziza, granular cyangwa fibrous, ifu yoroshye. Ugereranije uhagaze munsi yumucyo nubushuhe. Yaguka mumazi akonje kugirango ikore amata ya colloidal yumuti hamwe nubwiza runaka, kandi sol-gel interconversion phenomenon ibaho bitewe nubushyuhe bwubushyuhe bwumuti hamwe nibitekerezo runaka. Kubora cyane muri 70% Ethanol cyangwa dimethyl ketone, ariko ntibishobora gukomera muri Ethanol yuzuye, chloroform cyangwa ethoxyethane.
Agaciro pH ya hydroxypropyl methylcellulose iri hagati ya 4.0 na 8.0, kandi ifite ituze ryiza. Agaciro pH karahagaze hagati ya 3.0 na 11.0. Irashobora kubikwa kuri 20 ° C hamwe nubushuhe bwa 80% muminsi 10. Coefficente yo kwinjiza amazi ya HPMC ni 6.2%.
Hydroxypropyl methylcellulose ifite ubwoko bwibicuruzwa bitandukanye bitewe nibintu bitandukanye bigize imikorere ya hydroxypropyl mumiterere. Mubitekerezo byihariye, ubwoko butandukanye bwibicuruzwa bifite ubwiza bwihariye nubushuhe. Ubushyuhe bwa Gel bityo bukagira ibintu bitandukanye bishobora gukoreshwa mubikorwa bitandukanye. Buri farumasi ya farumasi yigihugu ifite ibyitegererezo bitandukanye nibisobanuro: Pharmacopoeia yu Burayi ishingiye ku mitsi itandukanye, urwego rutandukanye rwo gusimburwa, urwego rukoreshwa numubare wibyiciro bitandukanye byibicuruzwa bigurishwa ku isoko. Igice cya Reta zunzubumwe za Amerika Pharmacopoeia ni mPa · s, kandi amazina asanzwe ni aya akurikira Koresha imibare ine kugirango ugaragaze ibiri muri hydroxypropyl methylcellulose hamwe nimbaraga zitandukanye, nka hydroxypropyl methylcellulose, 2208. Imibare ibiri yambere igereranya ijanisha rigereranijwe. ya matsinda ya mikorerexy, nimibare ibiri yanyuma yerekana hydroxyl group. Ikigereranyo cya ijanisha rya propyl.
2. HPMC yashonga muburyo bwamazi
2.1 Uburyo bwamazi ashyushye
Kubera ko hydroxypropyl selulose idashobora gushonga mumazi ashyushye, irashobora gukwirakwizwa neza mumazi ashyushye hanyuma igakonja. Uburyo bubiri busanzwe bwatangijwe kuburyo bukurikira:
(1) Shira amazi asabwa muri kontineri hanyuma uyashyuhe kugeza kuri 70 ° C. Ongeramo ibicuruzwa gahoro gahoro mugihe ukurura buhoro. Ubwa mbere, ibicuruzwa bireremba hejuru y'amazi hanyuma bigenda buhoro buhoro.
. amazi kumazi ashyushye. gutobora mumazi, koga imvange nyuma yo gukonja.
2.2 Uburyo bwo kuvanga ifu
Ifu ya poro ikwirakwizwa neza no kuvanga byumye hamwe ningero zingana cyangwa nyinshi mubindi bikoresho byifu hanyuma bigashonga namazi, aho HMCS ishonga nta coagulation.
3. Ibyiza bya HPMC
3.1 Gushonga mumazi akonje
Irashobora gushonga mumazi akonje munsi ya 40 ℃ cyangwa 70% Ethanol, kandi ahanini ntishobora gushonga mumazi ashyushye hejuru ya 60 but, ariko irashobora kuza.
3.2 Kutagira imiti
HPMC ni selile ya ionic selile. Igisubizo cyacyo ntigifite ionic kandi ntigikorana numunyu wicyuma cyangwa ibinyabuzima kama. Kubwibyo, ibindi bicuruzwa ntibabyitwaramo mugihe cyo gutegura umusaruro.
3.3 Guhagarara
Irahamye kuri aside na alkali kandi irashobora kubikwa igihe kirekire hagati ya pH 3 na 1l nta mpinduka nini ihari. Ibisubizo byamazi ya hydroxypropyl methylcellulose (HPMC) birwanya antifungal kandi bikomeza guhagarara neza kwijimye mugihe cyo kubika igihe kirekire. Ihame ryiza rya HPMC ni ryiza kuruta ibicuruzwa gakondo (nka dextrin, krahisi, nibindi).
3.4 Guhindura ibishishwa
Inkomoko zinyuranye zikomoka kuri HPMC zirashobora kuba muburyo butandukanye, kandi ububobere bwazo burashobora guhinduka ukurikije ibikenewe gukurikiza amategeko amwe kandi bikagira umubano mwiza, bityo igipimo gishobora gutoranywa ukurikije ibikenewe.
3.5 Kutagira imbaraga
HPMC ntabwo yinjizwa cyangwa ngo ihindurwe mu mubiri kandi ntabwo itanga ubushyuhe, bityo rero ni ikintu cyiza cyo gutegura imiti.
3.6 Umutekano
Ubusanzwe HPMC ifatwa nkibikoresho bidafite uburozi, bidatera uburakari, hamwe na LD50 ya 5g / kg mu mbeba na 5.2g / kg mu mbeba. Ingano ya buri munsi ntacyo itwaye kubantu.
4 Gukoresha HPMC mugutegura
4.1 Ibikoresho byo gutwika firime nibikoresho byo gukora firime
Hydroxypropyl methylcellulose (HPMC) ikoreshwa nkibikoresho bya firime. Ibinini byayo bisize nta nyungu zigaragara kurenza ibinini bisanzwe bisize nk'isukari isize isukari mu rwego rwo guhisha uburyohe n'imiterere y'ibiyobyabwenge, ariko ubukana bwabyo, ubukana, hamwe na hygroscopique, gusenyuka nabi. , gutwikira ibiro kwiyongera nibindi bipimo byiza nibyiza. Urwego rwo hasi rwa viscosity rwibicuruzwa bikoreshwa nkibikoresho bifata amazi ya elegitoronike yifashisha ibinini n'ibinini, naho urwego rwo hejuru rwijimye rukoreshwa nkibikoresho byo gutwikisha firime ya sisitemu yo gukemura ibibazo. Ubusanzwe kwibanda kuri 2.0% ~ 20%.
4.2 Nkuguhuza no gutandukana
Urwego rwo hasi rwijimye rwibicuruzwa rushobora gukoreshwa nkuguhuza no gutandukanya ibinini, ibinini, na granules, mugihe urwego rwo hejuru rwijimye rushobora gukoreshwa gusa. Igipimo kiratandukanye ukurikije icyitegererezo n'ibisabwa, muri rusange 5% kubinini byumye byumye na 2% kubinini bitose.
4.3 Nka mfashanyo yo guhagarika
Umukozi uhagarika ni geli ya viscous gel ifite hydrophilique kandi irashobora gukoreshwa mugutinda umuvuduko wo gutuza kwingirangingo no kwizirika hejuru yibice kugirango ibuze guhurira mumipira. Imfashanyo yo guhagarika igira uruhare runini mukubyara ibikoresho byo guhagarika. HPMC ninyongera nziza yo guhagarikwa. Umuti wacyo wa elegitoronike urashobora kugabanya umuvuduko ukabije wimiterere nimbaraga zidafite imbaraga zingirakamaro, bityo bikazamura ituze rya sisitemu yo gukwirakwiza heterogeneous. Iki gicuruzwa nigikorwa cyo guhagarika cyane-viscosity ihagarikwa ningaruka nziza zo guhagarikwa, gutatanya byoroshye, urukuta rudakomeye, hamwe nuduce twiza twa flocculation. Igipimo cyacyo gisanzwe ni 0.5% kugeza 1.5%.
4.4 Nkumusemburo, uhoraho-urekura agent na porogen
Urwego rwohejuru rwinshi rwibicuruzwa bikoreshwa mugutegura hydrophilique gel matrix ikomeza-kurekura ibinini, ivangwa ryibikoresho bya matrix bikomeza-kurekura ibinini bya retarders hamwe nubushakashatsi bugenzura. Ifite ingaruka zo gutinda kurekura ibiyobyabwenge. Imikoreshereze yacyo ni 10% -80% (W / W). Urwego rwo hasi rwijimye rukoreshwa nkibibyimba bya pore muburyo burambye cyangwa bugenzurwa. Ibinini nk'ibi birashobora kugera ku ncuro ya mbere ikenewe kugira ngo bivurwe, hanyuma bitange ingaruka zihoraho cyangwa zigenzurwa, kandi bigumane imbaraga mu maraso mu mubiri. Hydroxypropyl methylcellulose hydrates mumazi kugirango ikore geli. Uburyo bwo kurekura ibiyobyabwenge byibinini bya matrix bikubiyemo cyane cyane ikwirakwizwa rya gel hamwe no gusesa geli.
4.5 Inkoko hamwe na koleide ikingira
Iyo iki gicuruzwa gikoreshwa nkibibyimbye, ibisanzwe bikoreshwa ni 0.45% ~ 1.0%. Iki gicuruzwa kirashobora kandi kongera ituze rya hydrophobique glue, gukora colloide ikingira, ikarinda uduce duto twa agglomeration hamwe na agglomeration, bityo bikabuza ishyirwaho ryimvura. Ihuriro rusange ryayo ni 0.5% ~ 1.5%.
4.6 Koresha nkibikoresho bya capsule
Mubisanzwe capsule shell material ya capsules ni gelatin. Igikorwa cyo gukora ibishishwa bya gelatine capsule biroroshye, ariko hariho ibibazo nibintu nko kurinda nabi imiti yangiza- na ogisijeni, kugabanya ibiyobyabwenge, no gutinda gusenyuka kwa capsule mugihe cyo kubika. Kubwibyo, hydroxypropyl methylcellulose ikoreshwa nkigisimbuza ibikoresho bya capsule mugutegura capsules, itezimbere gukora, kubumba no gukoresha ingaruka za capsules, kandi yazamuwe cyane mugihugu ndetse no mumahanga.
4.7 Nka bioadhesive
Ikoranabuhanga rya Bioadhesion rikoresha ibibyimba hamwe na polyaderi ya bioadhesive kugirango yubahirize mucosa yibinyabuzima kandi byongere imbaraga no gukomera kwimikoranire hagati yimyiteguro na mucosa, bituma imiti irekurwa buhoro buhoro kandi ikinjizwa na mucosa kugirango igere kubikorwa byo kuvura. Kugirango ugere ku ntego yo kuvura, kuri ubu ikoreshwa cyane mu kuvura indwara ziri mu cyuho cy'amazuru, mucosa yo mu kanwa no mu bindi bice by'umubiri. Gastrointestinal bioadhesion tekinoroji ni ubwoko bushya bwa sisitemu yo gutanga ibiyobyabwenge byakozwe mumyaka yashize. Ntabwo yongerera igihe cyo gutura gusa imiti yo gutegura ibiyobyabwenge mu nzira ya gastrointestinal, ahubwo inatezimbere imikorere yimikoranire hagati yibiyobyabwenge n’ahantu hacururizwa na selile kandi ihindura imiterere ya selile. Kugenda, ni ukuvuga, ibiyobyabwenge byinjira mu ngirabuzimafatizo zo mu nda, bityo
Igihe cyo kohereza: Gashyantare-01-2024