Hydroxypropyl Methylcellulose (HPMC) ni igice cya sintetike, inert, polymer-viscosity polymer ikoreshwa cyane mugutegura ibiyobyabwenge. Imiterere yihariye yumubiri nubumashini ituma iba ingenzi cyane mubikorwa bya farumasi, hamwe no gukora firime, kubyimba, gutuza no guhuza ibinyabuzima.
Ibintu shingiro bya HPMC
HPMC ikorwa na methylating na hydroxypropylating selile. Ifite amazi meza hamwe nubushyuhe bwa termoplastique, kandi igashonga vuba mumazi akonje kugirango ibe igisubizo kiboneye. Ihinduka ryayo hamwe nubwiza bwayo birashobora kugenzurwa muguhindura urwego rwo gusimbuza nu rwego rwa polymerisation, ibyo bigatuma HPMC ihaza ibikenerwa bitandukanye byimiti.
Ahantu ho gusaba
1. Kugenzura-kurekura ibiyobyabwenge
HPMC ikoreshwa cyane mugutegura imiti igenzurwa. Bitewe no gukomera kwamazi nubushobozi bwo gukora geles, HPMC irashobora kugena igipimo cyo kurekura ibiyobyabwenge. Umubyimba wacyo mu nzira ya gastrointestinal ituma imiti irekurwa buhoro buhoro mugihe runaka, igenzura neza plasma yibiyobyabwenge, kugabanya inshuro zimiti, no kunoza kubahiriza abarwayi.
2. Guhambira hamwe no gutandukanya ibinini
Nka binder kandi idatandukanya ibinini, HPMC irashobora kongera imbaraga zumukanishi wibinini mugihe byemeza ko ibinini byangirika kandi bikarekura ibintu bikora mugihe gikwiye. Ibikoresho bifata bifasha guhuza ibice byibiyobyabwenge hamwe kugirango bibe ibinini bikomeye, mugihe kubyimba kwayo bituma ibinini byangirika vuba mumazi.
3. Ibikoresho byo gutwika firime
HPMC nigikoresho cyingenzi mugutegura ibiyobyabwenge bya firime. Irashobora gukoreshwa nka firime ikingira kugirango irinde ibiyobyabwenge ubushuhe, ogisijeni n’umucyo, bityo imiti igahinduka. Byongeye kandi, HPMC irashobora kandi gukoreshwa nkigifuniko cya enteric kugirango irinde ibiyobyabwenge kurekurwa mu gifu no kureba ko ibiyobyabwenge byinjira mu mara.
4. Imyiteguro y'amaso
Mu myiteguro y'amaso, HPMC ikoreshwa mugutegura amarira yubukorikori n'amatonyanga y'amaso. Ubukonje bwayo bwinshi hamwe na biocompatibilité ituma ikora firime ikingira hejuru yijisho, gusiga amavuta, no kugabanya ibimenyetso byamaso yumye.
5. Capsules
HPMC irashobora gukoreshwa mugutegura capsules zikomeye hamwe na capsules yoroshye. Ugereranije na capsules ya gelatine gakondo, capsules ya HPMC ifite imiti ihamye yimiti, ntabwo byoroshye kwinjiza ubuhehere, kandi irangwa ninshuti kubarya ibikomoka ku bimera n’abizera b’amadini.
Impamvu
1. Viscosity
Ubukonje bwa HPMC nimwe mubimenyetso byingenzi byerekana imikorere yacyo. HPMC ifite ubukana bwinshi irashobora gukoreshwa mubiyobyabwenge bigenzurwa-bigasohora hamwe nogutegura firime, mugihe HPMC ifite ubukonje buke ikwiriye gukoreshwa nkuguhuza no gutandukana.
2. Impamyabumenyi yo gusimburwa
Urwego rwo gusimbuza (DS) no gusimbuza umubyimba (MS) wa HPMC bigira ingaruka ku buryo bworoshye bwo gukemura no gukora gel. Guhindura bikwiye urwego rwo gusimbuza birashobora guhindura ingaruka za HPMC muburyo butandukanye bwo gufata ibiyobyabwenge.
3. Ibidukikije
Imikorere ya HPMC nayo yibasiwe nibidukikije nkubushyuhe, agaciro ka pH nimbaraga za ionic. Izi ngingo zigomba kwitabwaho mugutegura imiti kugirango HPMC ikore neza.
Hydroxypropyl methylcellulose (HPMC), nkibikoresho byinshi, bikora neza cyane bya farumasi, bikoreshwa cyane mubice byinshi nko kurekura ibiyobyabwenge, ibinini, imyiteguro ya firime, imyiteguro y’amaso na capsules. Muguhindura ububobere bwacyo hamwe nintera yo gusimburwa, irashobora guhaza ibikenerwa byimiti itandukanye kandi igateza imbere cyane ihindagurika ryimiti nibinyabuzima. Hamwe niterambere ryiterambere rya tekinoroji yimiti, ibyifuzo bya HPMC bizaba binini.
Igihe cyo kohereza: Nyakanga-11-2024