Isesengura ryigihe cyo guseswa ningaruka ziterwa na hydroxypropyl methylcellulose (HPMC)

1. Intangiriro kuri HPMC

Hydroxypropyl Methylcellulose (HPMC) ni ether ya selile idafite ionic ikoreshwa cyane mubikoresho byo kubaka, gutwikira, imiti, kwisiga, ibiryo n'indi mirima. Bitewe nuburyo bwiza bwo gushonga kwamazi, gusya no kubyimba, HPMC ikoreshwa nkibyimbye, stabilisateur na gelling. Amazi meza ya HPMC nimwe mubintu byingenzi byingenzi mubikorwa bifatika, ariko igihe cyo kuyasesa kiratandukanye kubera ibintu byinshi.

2. Iseswa rya HPMC

HPMC ifite amazi meza, ariko mugihe cyo kuyasesa, igomba kubanza gufata amazi ikabyimba mbere, hanyuma igashonga buhoro buhoro. Ubu buryo busanzwe bugabanijwe mubice bikurikira:

Kwinjiza amazi no kubyimba: HPMC ibanza kwinjiza amazi mumazi, molekile ya selile itangira kubyimba.

Kuvangavangavanga: HPMC ikwirakwizwa mu mazi iringaniza cyangwa ubundi buryo bwa mashini kugirango wirinde guhuriza hamwe.

Gucika kugirango bibe igisubizo: Mugihe gikwiye, molekile ya HPMC irekura buhoro buhoro igashonga mumazi kugirango ibe igisubizo gihamye.

3. Igihe cyo gusesa HPMC

Igihe cyo gusesa HPMC ntigisanzwe, mubisanzwe kuva muminota 15 kugeza kumasaha menshi, kandi igihe cyihariye giterwa nibintu bikurikira:

Ubwoko nubwiza bwa HPMC: Uburemere bwa molekuline hamwe nubunini bwa HPMC bigira ingaruka zikomeye mugihe cyo gusesa. HPMC ifite ubukonje bwinshi bifata igihe kinini cyo gushonga, mugihe HPMC ifite ububobere buke bishonga vuba. Kurugero, 4000 cps HPMC irashobora gufata igihe kirekire kugirango ishonga, mugihe 50 cps HPMC irashobora gushonga burundu muminota 15.

Ubushyuhe bwamazi: Ubushyuhe nikintu cyingenzi kigira ingaruka kumyuka ya HPMC. Muri rusange, HPMC izakurura amazi kandi ikabyimba vuba mumazi akonje, ariko ishonga buhoro; mumazi ashyushye (nko hejuru ya 60°C), HPMC izakora leta idashobora gukemuka. Kubwibyo, "amazi akonje kandi ashyushye uburyo bubiri bwo gusesa" yo kubanza gukwirakwiza amazi akonje hanyuma gushyuha bikoreshwa muburyo bwihuse bwo gusesa.

Uburyo bwo gusesa: Uburyo bwo gusesa nabwo bugira uruhare runini mugihe cyo gusesa HPMC. Uburyo busanzwe bwo gusesa burimo gukanika imashini, kuvura ultrasonic cyangwa gukoresha ibikoresho byogosha byihuse. Gukangura imashini birashobora kongera igipimo cyo gusesa, ariko niba bidakozwe neza, birashobora gukora ibibyimba kandi bikagira ingaruka kumikorere. Gukoresha umuvuduko mwinshi wa stirrer cyangwa homogenizer birashobora kugabanya cyane igihe cyo gusesa.

Ingano ya HPMC: Nibice bito, niko umuvuduko wo gusesa byihuse. HPMC nziza-nziza biroroshye gutatanya no gushonga neza, kandi mubisanzwe bikoreshwa mugihe cyo gusaba hamwe nibisabwa cyane byo guseswa.

Umuti wa solvent: Nubwo HPMC ishonga cyane mumazi, irashobora kandi gushonga mumashanyarazi amwe n'amwe, nka Ethanol na propylene glycol ibisubizo byamazi. Sisitemu zitandukanye zo gukemura zizagira ingaruka ku gipimo cyo guseswa. Kumashanyarazi kama, igihe cyo kumeneka ni kirekire kuruta mumazi.

4. Ibibazo bisanzwe mubikorwa byo gusesa HPMC

Agglomeration phenomenon: HPMC ikunda gukora ibibyimba iyo bishonge mumazi, cyane cyane iyo ubushyuhe bwamazi buri hejuru cyangwa kubyutsa bidahagije. Ni ukubera ko hejuru ya HPMC ikurura amazi kandi ikaguka vuba, kandi imbere ntikirahura n’amazi, bikaviramo umuvuduko muke wibintu byimbere. Kubwibyo, mubikorwa nyabyo, akenshi bikoreshwa mukunyunyuza buhoro kandi buringaniza HPMC mumazi akonje mbere, hanyuma ukabyutsa neza kugirango wirinde agglomeration.

Iseswa rituzuye: Rimwe na rimwe igisubizo cya HPMC gisa kimwe, ariko mubyukuri igice cya selile ntigicika burundu. Muri iki gihe, birakenewe kongera igihe cyo gukurura, cyangwa guteza imbere iseswa hakoreshejwe ubushyuhe bukwiye hamwe nuburyo bukoreshwa.

5. Nigute ushobora guhindura igihe cyo gusesa HPMC

Koresha uburyo bwo gukwirakwiza amazi akonje: kuminjagira buhoro HPMC mumazi akonje kugirango wirinde agglomeration iterwa no kwinjiza amazi ako kanya no kwaguka. HPMC imaze gutandukana rwose, shyushya kuri 40-60°C guteza imbere iseswa ryuzuye rya HPMC.

Guhitamo ibikoresho bikurura: Kubireba ibintu bifite umuvuduko mwinshi wo gusesa, urashobora guhitamo gukoresha imashini yihuta yihuta, imashini itanga ibikoresho hamwe nibindi bikoresho kugirango wongere umuvuduko ukabije kandi bigabanye igihe cyo gusesa.

Kugenzura ubushyuhe: Kugenzura ubushyuhe nurufunguzo rwo gushonga HPMC. Irinde gukoresha amazi ashyushye hamwe n'ubushyuhe bukabije kugirango ushonga HPMC mu buryo butaziguye, ariko ukoreshe amazi akonje hanyuma ushushe. Kubisabwa bitandukanye, urashobora guhitamo ubushyuhe bukwiye ukurikije ibyo ukeneye.

Igihe cyo gusesa HPMC ninzira yingirakamaro yibasiwe nibintu byinshi. Muri rusange, igihe cyo gusesa cyiminota 15 kugeza kumasaha menshi nibisanzwe, ariko igihe cyo gusesa kirashobora kugabanywa cyane muguhindura uburyo bwo gusesa, gukurura umuvuduko, ingano yingingo no kugenzura ubushyuhe.