Menyekanisha
Hydroxypropyl methylcellulose, izwi cyane ku izina rya HPMC, ni polymer ibora amazi ikoreshwa cyane mubuvuzi, kwisiga, ibiryo n'inganda. HPMC irashobora gukoreshwa nkibyimbye, binder, emulifier na stabilisateur.
1. Hitamo icyiciro gikwiye cya HPMC
Ubushobozi bwa HPMC buterwa nuburemere bwa molekile, urugero rwo gusimburwa, nubunini buke. Guhitamo icyiciro gikwiye cya HPMC ni ngombwa kugirango ukemure neza muri porogaramu runaka.
Kurugero, uburemere buke bwa molekuline HPMC ifite imbaraga zo gukemura neza mumazi no mumashanyarazi kama kuruta uburemere buke bwa HPMC. Nyamara, uburemere buke bwa HPMC bufite imiterere-karemano yo gukora firime, bigatuma ibera neza.
Mu buryo nk'ubwo, HPMC ifite urwego rwo hejuru rwo gusimbuza irashonga cyane mu mazi kuruta HPMC ifite urwego ruto rwo gusimburwa. HPMC ifite urwego ruto rwo gusimburwa ikoreshwa muburyo burambye-burekura kuko ikora matrix ihamye kandi yuzuye.
Ingano ya HPMC nayo igira ingaruka ku gukemuka kwayo. HPMC ibice byiza bishonga vuba kuruta ibice bito. Kubwibyo, ni ngombwa guhitamo ingano ya HPMC ingano ya porogaramu runaka.
2. Koresha igisubizo gikwiye
Gukemura kwa HPMC biterwa na miterere ya solve. HPMC ibora mumazi hamwe na solge zimwe na zimwe, nka Ethanol, methanol, na alcool ya isopropyl. Nyamara, gukomera kwa HPMC mumashanyarazi kama biterwa na polarite yayo.
Amazi niyo akoreshwa cyane muri HPMC kuko ntabwo ari uburozi, buhendutse, kandi byoroshye kuboneka. Ubushobozi bwa HPMC mumazi burashobora kongerwamo imbaraga wongeyeho umunyu cyangwa ugahindura pH.
Uruganda rwa farumasi rusanzwe rukoresha ibishishwa kama nka Ethanol, methanol, na alcool ya isopropyl kugirango ushonga HPMC muburyo bwa tableti, capsules, nibisubizo byo munwa. Nubwo bimeze bityo ariko, hashobora kubaho imbogamizi zo gukoresha imiti kama, nkuburozi, umuriro, hamwe n’ibidukikije.
3. Uburyo bukwiye bwo gutatanya
Uburyo bwo gukwirakwiza HPMC mumashanyarazi nabwo bugira ingaruka kubikemura. Uburyo bukunze gukwirakwizwa HPMC ni granulation itose, aho HPMC ivangwa nibindi bisohoka kandi solvent ikongerwaho kugirango ikore paste. Iyo paste iruma hanyuma ikayungurura kugirango ibone granules.
Nyamara, tekinoroji idakwiye ya tekinoroji irashobora kuvamo gukomera no gukomera kwa HPMC mubicuruzwa byanyuma. Niyo mpamvu, ni ngombwa gukoresha uburyo bukwiye bwo guhunika neza (urugero, kuvanga neza, gukama, no gushungura) kugirango ubone granules zingana nubunini.
Ubundi buryo bwo gukwirakwiza HPMC nubuhanga bwumye bwa granulation yumye, aho HPMC ivangwa nibindi bisohoka hanyuma ikabikwa mubinini. Ibinini noneho birahinduka hanyuma bigashungura kugirango bibone granules. Iyo ukoresheje imiti yoroheje, granulation yumye irahitamo kandi imiti ntigomba gukoreshwa.
4. Imiterere yo kubika
Imiterere yububiko bwa HPMC nayo igira ingaruka kubikemura. HPMC igomba kubikwa ahantu humye, hakonje kandi hijimye kugirango hirindwe ubushuhe nizuba. Ubushuhe butera HPMC kubyimba, bityo bikagira ingaruka ku gukemuka kwayo.
Mu gusoza
Guhitamo icyiciro gikwiye cya HPMC, ukoresheje igisubizo gikwiye, tekinoroji ikwirakwiza, hamwe nuburyo bukwiye bwo kubika nibintu byingenzi bigira ingaruka kumyuka ya HPMC. Urebye ibi bintu, gukemura kwa HPMC birashobora gutezimbere kugirango ugere ku bwiza bwifuzwa bwibicuruzwa byanyuma.
Igihe cyo kohereza: Nzeri-13-2023