Hydroxypropyl methylcellulose (HPMC) ndi zinthu za polima zomwe zimagwiritsidwa ntchito popanga mankhwala.Chifukwa cha zinthu zake zabwino kwambiri zakuthupi komanso zamankhwala, zimagwira ntchito yofunika kwambiri pakupanga mapiritsi.HPMC angagwiritsidwe ntchito ngati filimu wakale, ankalamulira kumasulidwa wothandizila, zomatira, thickener, etc., kupereka mapiritsi dongosolo wabwino ndi ntchito.
1. Kanema wakale
Udindo wa HPMC ngati filimu wakale umawonekera makamaka pakuyala pamwamba pa mapiritsi otulutsidwa.Piritsi ❖ kuyanika ikuchitika ndi cholinga kulamulira mlingo amasulidwe mankhwala, kuteteza mankhwala ku zikoka chilengedwe, ndi kusintha maonekedwe a mankhwala.Pokonzekera kumasulidwa koyendetsedwa, filimu yopangidwa ndi HPMC imatha kusintha kuchuluka kwa mankhwala osokoneza bongo, kuonetsetsa kuti mankhwalawa amatulutsidwa m'madera ena a m'mimba, ndikupeza chithandizo chabwino kwambiri chamankhwala.
Kachitidwe Kachitidwe: Kanema wopangidwa ndi filimu ya HPMC wakale amatha kukwaniritsa kutulutsidwa kwamankhwala molamulidwa mwa kuwongolera kulowa kwa zosungunulira ndi kutha kwa mankhwala.Makulidwe ndi mawonekedwe a filimuyo amatha kusintha kuchuluka kwa kusungunuka kuti akwaniritse zofunikira zamankhwala osiyanasiyana.
Zotsatira: Mapiritsi ogwiritsira ntchito HPMC monga filimu yopangira mafilimu amatha kusungunuka pang'onopang'ono m'mimba, kupewa kutulutsa mankhwala mwadzidzidzi, kupititsa patsogolo kugwiritsa ntchito mankhwala osokoneza bongo, komanso kuchepetsa kukwiya kwa mankhwala m'mimba.
2. Wowongolera wotulutsa
HPMC nthawi zambiri imagwiritsidwa ntchito ngati matrix m'mapiritsi otulutsidwa kuti athe kuwongolera kuchuluka kwa mankhwala popanga chotchinga cha gel.Ntchito ya wothandizira wotulutsidwa ndikuwonetsetsa kuti mankhwalawa amatulutsidwa mofanana mkati mwa nthawi yeniyeni kuti apitirize kukhala ndi mphamvu ya mankhwala m'thupi, kuchepetsa chiwerengero cha nthawi ya dosing, ndi kupititsa patsogolo kumvera kwa odwala.
Njira yochitirapo kanthu: Muzofalitsa zamadzimadzi, HPMC imatha kuthira madzi mwachangu ndikupanga ma network a colloidal, omwe amawongolera kufalikira ndi kutulutsa kwamankhwala.Piritsi ikakumana ndi madzi, HPMC imatenga madzi ndikutupa kuti ipange gel wosanjikiza, momwe mankhwalawa amafalikira kunja kwa thupi, ndipo kuchuluka kwake kumadalira makulidwe ndi kachulukidwe ka gel osakaniza.
Impact: HPMC monga ankalamulira-kumasulidwa wothandizila akhoza kukhazikika mlingo kumasulidwa kwa mankhwala, kuchepetsa kusinthasintha kwa magazi mankhwala ndende, ndi kupereka khola achire zotsatira, makamaka mankhwala zochizira matenda aakulu.
3. Zomanga
Pokonzekera mapiritsi, HPMC imagwiritsidwa ntchito nthawi zambiri ngati chomangira kuti chiwongolere mphamvu zamakina a mapiritsi ndikuwonetsetsa kukhulupirika kwa mapiritsi panthawi yosungira, kuyendetsa ndi kuyendetsa.
Njira yochitirapo kanthu: HPMC, monga chomangira, imatha kupanga mgwirizano wamphamvu pakati pa tinthu tating'onoting'ono, kotero kuti ufa kapena tinthu tating'onoting'ono timalumikizana ndikupangidwa kukhala piritsi lolimba.Njirayi nthawi zambiri imachitika kudzera muukadaulo wonyowa granulation, pomwe HPMC imasungunuka mu njira yamadzimadzi kuti ipange yankho la viscous, ndikupanga piritsi lokhazikika pambuyo poyanika.
Zotsatira: Zomangira za HPMC zimatha kupititsa patsogolo mphamvu zopondereza komanso kuuma kwa mapiritsi, kuchepetsa chiwopsezo cha kupasuka kapena kugawanika, motero kumapangitsa kuti mapiritsi azikhala okhazikika komanso okhazikika.
4. Zonenepa
HPMC Angagwiritsidwenso ntchito monga thickener mu madzi Kukonzekera kusintha rheological zimatha Kukonzekera ndi kuonjezera mamasukidwe akayendedwe.
Limagwirira ntchito: HPMC ali mkulu mamasukidwe akayendedwe m'madzi ndi bwino kuonjezera mamasukidwe akayendedwe a madzi, kusintha kuyimitsidwa ndi bata la mankhwala, ndi kupewa sedimentation.
Zotsatira: Kuonjezera HPMC ku mankhwala amadzimadzi kungapangitse kuti mankhwalawo azifanana, apange zigawo za mankhwala kuti azigawidwa mofanana pokonzekera, ndikuwonetsetsa mlingo wokhazikika nthawi iliyonse.
Makhalidwe a Hydroxypropyl Methylcellulose
1. Zinthu Zakuthupi ndi Zamankhwala
HPMC ndi nonionic cellulose ether yokhala ndi kusungunuka kwamadzi bwino komanso kutentha kwamafuta.Amasungunuka mofulumira m'madzi ozizira kuti apange njira yowonekera, pamene kutentha, yankho limasanduka gel.
2. Biocompatibility
HPMC ali biocompatibility wabwino ndi chitetezo, ndipo si sachedwa chifukwa chitetezo kuyankha kapena poizoni zotsatira, choncho chimagwiritsidwa ntchito m'minda mankhwala ndi chakudya.
3. Kukhazikika kwa chilengedwe
HPMC ali bwino kukhazikika kwa zinthu zachilengedwe monga kutentha ndi pH mtengo, ndipo si sachedwa kuwonongeka kapena denaturation, amene amaonetsetsa bata la kukonzekera mankhwala posungira.
Zitsanzo za HPMC Application mu Mapiritsi
1. Mapiritsi Otulutsidwa Olamulidwa
Mwachitsanzo, mu mapiritsi a nifedipine omwe amagwiritsidwa ntchito pochiza matenda oopsa, HPMC imagwiritsidwa ntchito ngati matrix kuti athetse kutulutsidwa kwapang'onopang'ono kwa mankhwala, kuchepetsa nthawi zambiri, komanso kupititsa patsogolo kumvera kwa odwala.
2. Mapiritsi okhala ndi Enteric
M'mapiritsi okhala ndi enteric a proton pump inhibitors (monga omeprazole), HPMC imagwira ntchito ngati filimu yopanga filimu kuteteza mankhwalawa kuti asawonongedwe ndi chapamimba acid ndikuwonetsetsa kuti mankhwalawa amatulutsidwa bwino m'matumbo.
3. Mapiritsi omwe amasungunuka mwachangu
M`kamwa kudya-Kusungunuka mapiritsi zochizira matupi awo sagwirizana rhinitis, HPMC amachita monga thickener ndi zomatira kupereka mofulumira kuvunda ndi yunifolomu kumasulidwa, kuwongolera kukoma ndi kutenga zinachitikira mankhwala.
Hydroxypropyl methylcellulose amagwiritsidwa ntchito kwambiri popanga mapiritsi osiyanasiyana chifukwa cha mawonekedwe ake abwino kwambiri opanga filimu, kumasulidwa kwake, kumamatira komanso kukhuthala.HPMC osati kusintha thupi katundu ndi bata la mapiritsi, komanso kukhathamiritsa achire zotsatira za mankhwala ndi kusintha amasulidwe mlingo wa mankhwala.Ndi chitukuko chaukadaulo wamankhwala, kugwiritsa ntchito kwa HPMC kudzakhala kosiyanasiyana, kumapereka mwayi wowonjezera wokonzekera mankhwala.
Nthawi yotumiza: Jun-27-2024