Kukonzekera kosalekeza ndi kumasulidwa koyendetsedwa: Ma cellulose ethers monga HPMC (hydroxypropyl methylcellulose) amagwiritsidwa ntchito ngati zida za hydrogel skeleton pokonzekera kumasulidwa kosatha. Ikhoza kulamulira mlingo wotulutsidwa wa mankhwala m'thupi la munthu kuti akwaniritse zotsatira zochiritsira. Otsika mamasukidwe akayendedwe kalasi HPMC angagwiritsidwe ntchito ngati zomatira, thickener ndi suspending wothandizira, pamene mkulu-kukhuthala kalasi HPMC ntchito kusakaniza zinthu mafupa osakanikirana mapiritsi, makapisozi-kumasulidwa mosalekeza, ndi hydrophilic gel osakaniza mafupa okhazikika-kumasulidwa mapiritsi.
Wopangira mafilimu opanga mafilimu: HPMC ili ndi zinthu zabwino zopanga filimu, ndipo filimu yomwe imapangidwa imakhala yofanana, yowonekera, yolimba, komanso yosavuta kuitsatira. Ikhoza kusintha kukhazikika kwa mankhwalawa ndikuletsa kusinthika. Magulu ambiri a HPMC ndi 2% mpaka 10%.
Zothandizira pazamankhwala: Ma cellulose ethers amagwira ntchito yofunika kwambiri pokonzekera kuumba monga zopangira mankhwala, monga ma pellets otuluka mosalekeza, kukonzekera kotulutsidwa kwa mafupa, kukonzekera kumasulidwa kosalekeza, makapisozi omasulidwa mosalekeza, makanema otulutsa mankhwala osatha, utomoni wamankhwala osokoneza bongo. kumasulidwa kukonzekera ndi madzi okhazikika-kumasulidwa kukonzekera.
Microcrystalline Cellulose (MCC): MCC ndi mtundu wa mapadi omwe amagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, makamaka pakuponderezana kwachindunji ndi njira zowuma za granulation monga kuphatikizika kwa ma roller kuti akonze mapiritsi oponderezedwa kapena ma granules.
Ma bioadhesives: Cellulose ethers, makamaka zotumphukira za nonionic ndi anionic ether monga EC (ethylcellulose), HEC (hydroxyethylcellulose), HPC (hydroxypropylcellulose), MC (methylcellulose), CMC (carboxymethylcellulose) kapena HPMC (hydroxypropylmethylsivecellulose) mu bio. Ma polima awa atha kugwiritsidwa ntchito pakamwa, m'maso, kumaliseche ndi kutulutsa bioadhesives, payekha kapena kuphatikiza ndi ma polima ena.
Thickeners ndi Stabilizers: Zochokera ku cellulose zimagwiritsidwa ntchito kwambiri kukulitsa mayankho amankhwala ndi machitidwe obalalika monga emulsions ndi kuyimitsidwa. Ma polima awa amatha kukulitsa kukhuthala kwa njira zopanda madzi zamadzimadzi monga njira zopangira organic. Kuchulukitsa mamasukidwe akayendedwe a mankhwala akhoza kusintha bioavailability wa apakhungu ndi mucosal kukonzekera.
Zodzaza: Ma cellulose ndi zotumphukira zake amagwiritsidwa ntchito ngati zodzaza mumitundu yolimba monga mapiritsi ndi makapisozi. Iwo n'zogwirizana ndi ambiri excipients, pharmacologically inert, ndipo osati kugayidwa ndi michere anthu m'mimba.
Zomangira: Ma cellulose ethers amagwiritsidwa ntchito ngati zomangira panthawi ya granulation kuthandiza ma granules kupanga ndi kusunga kukhulupirika kwawo.
Makapisozi a zomera: Ma cellulose ethers amagwiritsidwanso ntchito kupanga makapisozi a zomera, m'malo mwa chilengedwe, osati makapisozi opangidwa ndi nyama.
Njira zoperekera mankhwala osokoneza bongo: Ma cellulose ethers angagwiritsidwe ntchito popanga njira zosiyanasiyana zoperekera mankhwala osokoneza bongo, kuphatikizapo machitidwe olamuliridwa ndi ochedwetsa, komanso machitidwe opangira mankhwala opangidwa ndi malo enieni kapena nthawi yake.
Kugwiritsiridwa ntchito kwa ma cellulose ethers m'makampani opanga mankhwala kukukulirakulirabe, ndipo pakupangidwa kwamitundu yatsopano yamankhwala ndi zowonjezera zatsopano, kukula kwa msika komwe akufuna kukuyembekezeka kukulirakulira.
Nthawi yotumiza: Oct-31-2024