Hydroxypropyl methylcellulose (HPMC) ndi cellulose ether yofunika kwambiri, yomwe imagwiritsidwa ntchito kwambiri pomanga, mankhwala, chakudya, mankhwala a tsiku ndi tsiku ndi zina. HPMC ndi polima osungunuka m'madzi omwe amapezedwa ndi kusinthidwa kwamankhwala a cellulose achilengedwe, okhala ndi zinthu zambiri zabwino zakuthupi ndi zamankhwala.
1. Zinthu zakuthupi
Maonekedwe ndi morphology: HPMC nthawi zambiri imakhala yoyera kapena yachikasu pang'ono ufa, yopanda fungo, yopanda kukoma, ndipo imakhala ndi madzi abwino. Ikhoza kupanga filimu yofananira kapena gel osakaniza kudzera mu njira zosiyanasiyana zogwirira ntchito, zomwe zimapangitsa kuti zizichita bwino pamagwiritsidwe ambiri.
Kusungunuka: HPMC imasungunuka mosavuta m'madzi ozizira, koma osasungunuka m'madzi otentha. Kutentha kukafika pamlingo wina (nthawi zambiri 60-90 ℃), HPMC imataya kusungunuka m'madzi ndikupanga gel. Katunduyu amathandizira kuti azitha kukhuthala akatenthedwa, ndikubwerera kumalo owoneka bwino amadzimadzi pambuyo pozizirira. Komanso, HPMC ndi pang'ono sungunuka mu zosungunulira organic monga Mowa.
Viscosity: The mamasukidwe akayendedwe a HPMC yankho ndi chimodzi mwa zinthu zake zofunika thupi. The mamasukidwe akayendedwe zimadalira maselo ake kulemera ndi ndende ya yankho. Nthawi zambiri, kukula kwa mamolekyu olemera, kumapangitsanso kukhuthala kwa yankho. HPMC ali osiyanasiyana mamasukidwe akayendedwe ndi zikhoza kusinthidwa malinga ndi zofunika ntchito yeniyeni, zomwe zimapangitsa kuti chimagwiritsidwa ntchito yomanga, mankhwala, mankhwala tsiku ndi mafakitale ena.
Katundu wopanga mafilimu: HPMC ili ndi malo abwino kwambiri opangira mafilimu. Ikhoza kupanga filimu yowonekera komanso yolimba pambuyo pa kusungunuka m'madzi kapena organic solvents. Firimuyi ili ndi mafuta abwino komanso kukana mafuta, choncho nthawi zambiri amagwiritsidwa ntchito ngati chophimba pazakudya ndi mankhwala. Kuphatikiza apo, filimu ya HPMC ilinso ndi kukana bwino kwa chinyezi ndipo imatha kuteteza zinthu zamkati ku chinyezi.
Kukhazikika kwamafuta: HPMC ili ndi kukhazikika kwamafuta abwino. Ngakhale kuti imataya kusungunuka ndikupanga gel pa kutentha kwakukulu, imakhala ndi kukhazikika kwabwino kwa kutentha m'malo owuma ndipo imatha kupirira kutentha kwapamwamba popanda kuwonongeka. Mbali imeneyi amapereka mwayi mkulu-kutentha processing.
2. Mankhwala katundu
Kukhazikika kwa Chemical: HPMC ili ndi kukhazikika kwamankhwala bwino kutentha kwa chipinda ndipo imakhala yokhazikika ku ma acid, alkalis ndi mchere. Choncho, muzochitika zambiri zamakina kapena machitidwe opangira, HPMC ikhoza kukhalapo ngati stabilizer ndipo sizovuta kuchitapo kanthu ndi mankhwala ndi zosakaniza zina.
Kukhazikika kwa pH: HPMC imakhalabe yokhazikika mu pH 2-12, zomwe zimapangitsa kuti zigwiritsidwe ntchito m'malo osiyanasiyana a pH. HPMC sadzakhala kukumana hydrolysis kapena kuwonongeka pansi zinthu acidic kapena zamchere, zomwe zimapangitsa kuti chimagwiritsidwa ntchito mu chakudya, mankhwala, ndi zodzoladzola.
Biocompatibility and non-toxicity: HPMC ili ndi biocompatibility yabwino ndipo itha kugwiritsidwa ntchito mosamala muzamankhwala, chakudya ndi magawo ena omwe ali ndi zofunika kwambiri paumoyo wamunthu. HPMC si poizoni ndi osakwiyitsa, ndipo sidzaphwanyidwa mu mamolekyu ang'onoang'ono ndi michere m'mimba m'thupi, kotero angagwiritsidwe ntchito ngati ankalamulira kumasulidwa wothandizila mankhwala kapena thickener chakudya.
Kusintha kwa Chemical: HPMC ili ndi magulu ambiri a hydroxyl mu kapangidwe kake ka mamolekyulu, omwe amatha kuwongolera kapena kupatsidwa zinthu zatsopano posinthanso mankhwala. Mwachitsanzo, pochita ndi ma aldehydes kapena ma organic acid, HPMC imatha kukonza zinthu zokhala ndi kutentha kwambiri kapena kukana madzi. Kuphatikiza apo, HPMC imathanso kusakanikirana ndi ma polima ena kapena zowonjezera kuti apange zida zophatikizika kuti zikwaniritse zosowa za ntchito zina.
Kutengera chinyezi: HPMC ili ndi hygroscopicity yolimba ndipo imatha kuyamwa chinyezi kuchokera mumlengalenga. Katunduyu amalola HPMC kuti ikhwime komanso kuwongolera chinyezi chazinthuzo pamapulogalamu ena. Komabe, nthawi zina, kuyamwa kwambiri kwa chinyezi kumatha kukhudza kukhazikika kwa chinthucho, chifukwa chake momwe chinyezi chozungulira chimagwirira ntchito pakuchita kwa HPMC kuyenera kuganiziridwa mukamagwiritsa ntchito.
3. Ntchito minda ndi ubwino
Chifukwa cha mawonekedwe ake apadera akuthupi ndi mankhwala, HPMC ili ndi mitundu ingapo yamagwiritsidwe ntchito m'magawo ambiri. Mwachitsanzo, pantchito yomanga, HPMC imagwiritsidwa ntchito ngati chowonjezera komanso chosungira madzi pazinthu zopangira simenti kuti zithandizire kupanga komanso kulimba kwa zida zomangira; m'munda wamankhwala, HPMC nthawi zambiri imagwiritsidwa ntchito ngati zomatira piritsi, zowongolera zotulutsa, ndi zida zokutira za capsule; m'munda wa chakudya, amagwiritsidwa ntchito ngati thickener, emulsifier, ndi stabilizer kuwongolera kukoma ndi kapangidwe ka chakudya.
Hydroxypropyl methylcellulose imagwira ntchito yosasinthika m'mafakitale ambiri chifukwa champhamvu zake zakuthupi komanso zamankhwala. Kuchita kwake kwapadera pakusungunuka kwamadzi, kupanga mafilimu, kukhazikika kwamankhwala, ndi zina zotere kumapangitsa HPMC kukhala chinthu chofunikira kwambiri pamakampani ndi moyo watsiku ndi tsiku.
Nthawi yotumiza: Aug-22-2024