Hydroxypropyl Methylcellulose (HPMC) ndi nonionic cellulose ether yomwe imagwiritsidwa ntchito kwambiri m'mafakitale monga zomangamanga, mankhwala, chakudya, zodzoladzola ndi zokutira. Kusinthasintha kwake kumachokera kuzinthu zake zapadera za physicochemicals monga thickening, kugwirizana, kupanga mafilimu, kusunga madzi ndi mafuta. Mitundu yosiyanasiyana ya HPMC imayikidwa molingana ndi digiri ya m'malo (DS) ndi methoxy ndi hydroxypropyl, kuwonjezera kukhuthala kwawo, kukula kwa tinthu ndi chiyero. Magiredi osiyanasiyana awa a HPMC ali ndi mawonekedwe osiyanasiyana ogwiritsira ntchito.
1. Methoxy content ndi hydroxypropyl content
Zomwe zili m'malo mwa methoxy ndi hydroxypropyl za HPMC ndiye chinthu chofunikira kwambiri chomwe chimatsimikizira magwiridwe ake. Nthawi zambiri, methoxy zomwe zili mu HPMC zili pakati pa 19% ndi 30%, ndipo hydroxypropyl ili pakati pa 4% ndi 12%. HPMC yokhala ndi zinthu zambiri za methoxy nthawi zambiri imakhala ndi kusungunuka kwabwinoko komanso kupanga filimu, pomwe HPMC yokhala ndi ma hydroxypropyl apamwamba imakhala ndi kusungunuka bwino komanso kusunga madzi. Izi magawo zimakhudza mwachindunji ntchito HPMC. Mwachitsanzo, m'makampani omanga, ma methoxy apamwamba amathandiza kukonza kusungidwa kwa madzi ndi ntchito yomanga matope; m'munda wamankhwala, kuchuluka kwa hydroxypropyl kumathandizira kukonza kaphatikizidwe ndi kutulutsa kwamankhwala.
2. Kukhuthala kwa kalasi
HPMC akhoza kugawidwa mu otsika mamasukidwe akayendedwe, sing'anga mamasukidwe akayendedwe ndi mkulu mamasukidwe akayendedwe sukulu malinga ndi mamasukidwe akayendedwe a yankho lake. Viscosity ndi chinthu chofunikira chakuthupi cha HPMC, chomwe nthawi zambiri chimayesedwa ndi kukhuthala kwa 2% yankho mumasekondi a milliPascal (mPa.s).
Low viscosity HPMC (monga 5 mPa.s mpaka 100 mPa.s): Mtundu uwu wa HPMC nthawi zambiri umagwiritsidwa ntchito pazinthu zomwe zimafuna kuchepetsa kukhuthala, monga madontho a maso, kupopera ndi zodzoladzola. Mu ntchito izi, otsika mamasukidwe akayendedwe HPMC angapereke fluidity wabwino ndi kugawa yunifolomu.
Sing'anga mamasukidwe akayendedwe HPMC (mwachitsanzo 400 mPa.s kuti 2000 mPa.s): Yapakatikati mamasukidwe akayendedwe HPMC ambiri ntchito zomangira, emulsions ndi zomatira kupereka zolimbitsa thickening zotsatira, amene angathe kulinganiza ntchito yomanga ndi mphamvu thupi la chomaliza.
High viscosity HPMC (monga 4000 mPa.s mpaka 200,000 mPa.s): High viscosity HPMC amagwiritsidwa ntchito makamaka pa ntchito zomwe zimafuna kukhuthala kwakukulu, monga matope, putty, zomatira matailosi ndi zokutira. Muzinthu izi, kukhuthala kwakukulu kwa HPMC kumathandizira kusungirako madzi, kutsutsa-kugwedezeka ndi mphamvu zomangira.
3. Kukula kwa tinthu ting'onoting'ono
Kukula kwa tinthu ta HPMC kumakhudzanso ntchito yake. Nthawi zambiri, HPMC ikhoza kugawidwa mu tinthu tating'onoting'ono komanso tinthu tating'onoting'ono. Tinthu tating'onoting'ono HPMC nthawi zambiri imagwiritsidwa ntchito pamapulogalamu omwe amafunikira kusungunuka kapena kubalalitsidwa mwachangu, pomwe tinthu tating'onoting'ono ta HPMC ndi yoyenera pazinthu zomwe zili ndi zofunika kwambiri pamawonekedwe kapena zimafuna kugawa yunifolomu.
Coarse-grained HPMC: HPMC yokhala ndi tinthu tating'onoting'ono tokhala ndi tinthu tating'onoting'ono tomwe timasungunuka mumatope owuma ndi madera ena, ndipo imatha kupanga njira yofananira, potero imathandizira kupanga bwino.
Fine-grained HPMC: Fine-grained HPMC imagwiritsidwa ntchito kwambiri m'mafakitale monga utoto, zokutira ndi zodzola. Ikhoza kupanga filimu yowonjezereka yowonjezereka panthawi yogwiritsira ntchito, kukonza gloss ndikumverera kwa mankhwala.
4. Kuyera ndi magiredi apadera
Malinga ndi zofunikira zosiyanasiyana zogwiritsira ntchito, HPMC imatha kuyeretsedwanso kapena kusinthidwa. HPMC yokhala ndi chiyero chapamwamba nthawi zambiri imagwiritsidwa ntchito m'mafakitale opanga mankhwala ndi chakudya kuonetsetsa chitetezo ndi biocompatibility ya mankhwalawa. Kuonjezera apo, pali ma HPMC omwe ali ndi ntchito zapadera, monga HPMC yolumikizana ndi mtanda, HPMC yopangidwa ndi pamwamba, ndi zina zotero.
Pharmaceutical grade HPMC: Pharmaceutical grade HPMC ili ndi chiyero chapamwamba ndipo ndi yoyenera pamapiritsi, makapisozi ndi kukonzekera kosalekeza, zomwe zingathe kusintha kwambiri mlingo wotulutsidwa ndi kukhazikika kwa mankhwala.
Chakudya kalasi HPMC: Chakudya kalasi HPMC ntchito monga chakudya thickener, stabilizer ndi emulsifier kuonetsetsa chitetezo ndi kukoma kwa chakudya.
Industrial grade HPMC: HPMC yomwe imagwiritsidwa ntchito pomanga, zokutira ndi minda ina imatha kukhala ndi zonyansa zochepa, koma imatha kupereka chuma chambiri komanso magwiridwe antchito abwino.
5. Minda yofunsira ndi kusankha
Makalasi osiyanasiyana a HPMC amagwiritsidwa ntchito kwambiri pomanga, mankhwala, chakudya, zodzoladzola ndi zina. Posankha kalasi yoyenera HPMC, zinthu monga mamasukidwe akayendedwe, okhutira substituent, tinthu kukula ndi chiyero ayenera kuganiziridwa malinga ndi zosowa za ntchito yeniyeni.
Munda womanga: Pazomangira, HPMC imagwiritsidwa ntchito kwambiri ngati chowuma, chosungira madzi komanso chomangira. Kwa ntchito monga matope owuma ndi zomatira matailosi, ndikofunikira kusankha HPMC yokhala ndi mamasukidwe oyenera komanso kusunga madzi.
Munda wamankhwala: Pokonzekera mankhwala, HPMC imagwiritsidwa ntchito ngati zida za kapisozi, zokutira ndi zomatira. Ndikofunikira kusankha magiredi a HPMC okhala ndi magwiridwe antchito oyenera otulutsa mankhwala komanso kuyanjana kwachilengedwe.
Chakudya ndi zodzoladzola: M'makampani azakudya ndi zodzoladzola, HPMC imagwiritsidwa ntchito ngati chowonjezera komanso chokhazikika, ndipo chiyero ndi chitetezo chake ndizofunikira kwambiri.
Magulu osiyanasiyana a Hydroxypropyl Methylcellulose (HPMC) ali ndi zabwino zawo komanso kuchuluka kwake pazogwiritsa ntchito. Kumvetsetsa ndikusankha kalasi yoyenera ya HPMC kumatha kupititsa patsogolo magwiridwe antchito ndi mtundu wazinthu ndikukwaniritsa zosowa zamafakitale osiyanasiyana ndi ogula.
Nthawi yotumiza: Aug-21-2024