Kodi hypromellose phthalate ndi chiyani?

Hypromellose phthalate (HPMCP) ndi mtundu wa mankhwala omwe amagwiritsidwa ntchito popanga mafomu a mlingo wapakamwa, makamaka popanga mapiritsi okhala ndi enteric ndi makapisozi. Amachokera ku cellulose, yomwe ndi polima yachilengedwe yomwe imapanga gawo la makoma a cellulose. HPMCP ndi polima yosungunuka m'madzi, anionic polima yomwe imagwiritsidwa ntchito ngati chotchingira cha enteric chifukwa cha mawonekedwe ake abwino kwambiri opangira mafilimu, kukhazikika, komanso kukana madzi am'mimba.

HPMCP idayambitsidwa koyamba koyambirira kwa zaka za m'ma 1970 ndipo kuyambira pamenepo yakhala chinthu chotchingira chogwiritsidwa ntchito kwambiri chifukwa cha mawonekedwe ake apadera. Amapangidwa ndi esterification ya hypromellose yokhala ndi phthalic acid ndipo imapezeka m'makalasi osiyanasiyana, kutengera kuchuluka kwa phthalation ndi kulemera kwa ma polima. Magiredi omwe amagwiritsidwa ntchito kwambiri a HPMCP ndi HPMCP-55, HPMCP-50, ndi HPMCP-HP-55, omwe ali ndi madigiri osiyanasiyana a phthalation ndipo ndi oyenera kugwiritsidwa ntchito mumitundu yosiyanasiyana ya mapangidwe.

Ntchito yayikulu ya HPMCP pakupanga mankhwala ndikuteteza zinthu zomwe zimagwiritsidwa ntchito ndi mankhwalawa kuti zisawonongeke m'malo a acidic am'mimba. Piritsi kapena capsule yomwe ili ndi HPMCP imalowetsedwa, chophimbacho chimakhalabe m'mimba chifukwa cha pH yochepa, koma mawonekedwe a mlingo akafika kumalo amchere amchere a m'matumbo aang'ono, chophimbacho chimayamba kusungunuka ndi kumasula zinthu zogwira ntchito. Kutulutsidwa kochedwa kumeneku kumathandiza kuonetsetsa kuti mankhwalawa aperekedwa kumalo ochitirapo kanthu komanso kuti mphamvu zake sizikusokonezedwa ndi chapamimba asidi.