Hydroxypropylmethylcellulose (HPMC) ndi chimodzi mwazinthu zomwe zimagwiritsidwa ntchito kwambiri m'mafakitale azamankhwala ndi zakudya komanso m'makampani omanga. Mmodzi mwa ubwino waukulu wa HPMC ndi luso kusunga madzi, zomwe zimapangitsa kukhala abwino kwa zosiyanasiyana ntchito. Ntchito yosungira madzi ya HPMC imakhudzidwa ndi zinthu zambiri, kuphatikizapo kukhuthala, zomwe zili, kutentha kwapakati ndi kapangidwe ka maselo.
mamasukidwe akayendedwe
Chimodzi mwazinthu zazikulu zomwe zimakhudza kasungidwe ka madzi ka HPMC ndi kukhuthala kwake. Viscosity imatanthauza makulidwe kapena kukana kuyenda kwa chinthu. Kwa HPMC, kukwezeka kwa viscosity kumapangitsa kuti madzi asungidwe.
Apamwamba mamasukidwe akayendedwe HPMC ali apamwamba maselo kulemera, kutanthauza yaitali polima unyolo. Unyolo wautali umapangitsa kuti zikhale zovuta kuti mamolekyu amadzi adutse muzinthuzo. Izi zimapangitsa kuti madzi asamasungidwe kwambiri chifukwa mamolekyu amadzi amatsekeredwa mkati mwa matrix a polima, zomwe zimapangitsa mphamvu yonse ya matrix.
zomwe zili
Chinanso chomwe chimakhudza kasungidwe ka madzi ka HPMC ndi zomwe zili. HPMC imakhala ndi zigawo ziwiri zazikulu zokhala ndi milingo yosiyanasiyana ya hydrophilicity, yomwe ndi methoxyl ndi hydroxypropyl. Kukwera kwa hydroxypropyl mu HPMC, kumapangitsanso kuti madzi asungidwe.
Gulu la hydroxypropyl mu HPMC limatsimikizira momwe amasungira madzi. Maguluwa amakopa ndikusunga mamolekyu amadzi, zomwe zimapangitsa HPMC kutupa. Kutupa kumeneku kumathandiza kupanga chotchinga chomwe chimachepetsa kutuluka kwa madzi kuchokera ku HPMC. Magulu a Methoxy, kumbali ina, sali ngati hydrophilic monga magulu a hydroxypropyl ndipo motero samathandizira kwambiri kuti madzi asungidwe.
kutentha kozungulira
Kutentha kozungulira ndi chinthu china chomwe chimakhudza kasungidwe ka madzi ka HPMC. Pamene kutentha kumawonjezeka, mphamvu yosungira madzi ya HPMC imachepa. Izi zimachitika chifukwa pa kutentha kwakukulu, maunyolo a polima a HPMC amakhala ndi mphamvu zambiri zamakinetic, ndipo amayenda mwachangu. Chifukwa chake, mamolekyu amadzi amamasulidwa mwachangu kuchokera ku ma polima. Komanso, pa kutentha kochepa, mamolekyu amadzi amakhazikika kwambiri mu matrix a HPMC, zomwe zimapangitsa kuti madzi azikhala ochuluka.
Chifukwa chake, ndikofunikira kuwongolera kutentha kozungulira panthawi yopanga kuti muwonetsetse kuti ntchito yosunga madzi imakhazikika komanso yodalirika.
Kapangidwe ka Maselo
Mphamvu yosungira madzi ya HPMC imakhudzidwanso ndi kapangidwe kake ka maselo. Mapangidwe a mamolekyu a HPMC amatsimikiziridwa ndi kuchuluka kwa m'malo (DS) ndi kugawa kulemera kwa maselo.
Mlingo wolowa m'malo umatanthawuza momwe magulu a hydroxyl a cellulose amalowetsedwa ndi magulu a hydroxypropyl. HPMC yokhala ndi digiri yapamwamba yolowa m'malo imakhala ndi mphamvu yosungira madzi. Mosiyana ndi izi, HPMC yokhala ndi digiri yotsika yoloweza m'malo imakhala ndi mphamvu yochepetsera madzi.
Kugawa kwa maselo a HPMC kumakhudzanso mphamvu yosungira madzi. Kulemera kwa mamolekyu kumapangitsa kuti madzi asamasungidwe bwino, chifukwa mamolekyu akuluakulu amapanga kachidutswa kakang'ono kamene kamasunga mamolekyu amadzi molimba kwambiri.
Pomaliza
HPMC ndi zinthu zopindulitsa kwambiri chifukwa cha zinthu zake zabwino zosungira madzi. Mphamvu yosungira madzi ya HPMC imagwirizana mwachindunji ndi kukhuthala kwake, zomwe zili, kutentha kozungulira komanso kapangidwe ka maselo. Chifukwa chake, kusankha HPMC yoyenera pakugwiritsa ntchito kwina kumafuna kuganizira mozama pazinthu izi. Ponseponse, HPMC imakhudza ubwino ndi mphamvu ya zinthu zosiyanasiyana m'mafakitale angapo, kuphatikizapo mankhwala, chakudya, ndi zomangamanga.
Nthawi yotumiza: Aug-30-2023