Hydroxypropylcellulose (HPC) ndi gawo lofunikira la cellulose lomwe limagwiritsidwa ntchito kwambiri m'minda yamankhwala, chakudya ndi zodzola. Kugwiritsiridwa ntchito kwake muzoyimitsidwa kumakhala kodziwika kwambiri, makamaka chifukwa cha makulidwe ake, kukhazikika ndi kusungunula katundu kuti apititse patsogolo kukhazikika kwa kuyimitsidwa.
Basic katundu wa hydroxypropylcellulose
Hydroxypropyl cellulose ndi nonionic cellulose ether yomwe imapezeka ndi hydroxypropylation ya cellulose yachilengedwe. Gulu la hydrophilic hydroxypropyl limalowetsedwa mu kapangidwe kake ka mankhwala, ndikulipatsa kusungunuka kwabwino komanso kukhuthala m'madzi. HPC ili ndi izi:
Kusungunuka kwabwino: HPC imatha kusungunuka m'madzi ozizira komanso otentha, kupanga yankho lomveka bwino komanso lowoneka bwino.
High biocompatibility: HPC ili ndi biocompatibility yabwino komanso kawopsedwe kakang'ono, motero imagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala ndi zakudya.
Kukhazikika kwamphamvu kwamafuta: HPC imakhala ndi kukhazikika kwamafuta ambiri ndipo imatha kukhalabe yolimba komanso yokhazikika mkati mwa kutentha kwina.
thickening zotsatira
Imodzi mwa ntchito zazikulu za HPC pakuyimitsidwa ndikukhuthala. Powonjezera kuchuluka koyenera kwa HPC kuyimitsidwa, kukhuthala kwamadzimadzi kumatha kuchuluka kwambiri, potero kumachepetsa kuthamanga kwa tinthu tating'onoting'ono. Malinga ndi lamulo la Stokes, kuthamanga kwa tinthu tating'onoting'ono kumayenderana ndi kukhuthala kwamadzimadzi. Choncho, ndi kuonjezera mamasukidwe akayendedwe a kuyimitsidwa, ndi kuthetsa particles akhoza mogwira anachedwa ndi bata la kuyimitsidwa kumatheka.
Kukhuthala kwa HPC makamaka kumabwera chifukwa cha kulemera kwake kwa mamolekyulu komanso momwe amalumikizirana pakati pa maunyolo a maselo. HPC ikasungunuka m'madzi, mamolekyu amtali-utali amawonekera ndikumangirirana wina ndi mnzake munjirayo, ndikupanga dongosolo lovuta la maukonde. Izi maukonde dongosolo akhoza kwambiri kuonjezera mamasukidwe akayendedwe a yankho, kupangitsa kukhala kovuta kuti olimba particles kusuntha mu madzi, potero kuwongolera bata la kuyimitsidwa.
Kukhazikika kwamphamvu
Udindo wina wofunikira wa HPC ndikuwongolera kukhazikika kwa kuyimitsidwa. Kuphatikiza pa kukhuthala kwake, HPC imakhalanso ndi ntchito yabwino kwambiri yolumikizirana komanso kuthekera kopanga zomatira zoteteza. Mamolekyu a HPC amatha kutsatiridwa pamwamba pa tinthu tating'onoting'ono kuti tipange guluu woteteza kuti tinthu ting'onoting'ono zisaphatikizidwe ndikukhazikika.
Zomatira zodzitchinjirizazi zimakhazikika kuyimitsidwa kudzera pakubweza kwa electrostatic ndi zolepheretsa zolepheretsa. Choyamba, gulu la hydroxypropyl mu molekyulu ya HPC imatha kupanga zomangira za haidrojeni ndi mamolekyu amadzi, ndikuwonjezera hydrophilicity ya tinthu tating'onoting'ono ndikuwonjezera kubalalitsidwa kwa tinthu tating'ono m'madzi. Kachiwiri, kukhalapo kwa HPC maselo unyolo kupanga chotchinga thupi pa tinthu pamwamba, kuteteza kukhudzana mwachindunji pakati particles, potero kuchepetsa tinthu aggregation ndi sedimentation.
Solubilization
Zotsatira zosungunulira za HPC pakuyimitsidwa sizinganyalanyazidwe. Kwa mankhwala ena osasungunuka bwino kapena zosakaniza zogwira ntchito, HPC imatha kusungunuka m'madzi popanga ma molecular inclusion complexes kapena micelles. Gulu la hydroxypropyl mu molekyulu ya HPC limatha kupanga kuyanjana kofooka (monga ma hydrogen bond kapena van der Waals forces) ndi mamolekyu osasungunuka bwino, potero kumapangitsa kusungunuka kwake m'madzi.
Kupyolera mu izi solubilization zotsatira, HPC osati kuonjezera solubility wa zinthu bwino sungunuka mu kuyimitsidwa, komanso kusintha yunifolomu kugawa mu madzi, kupititsa patsogolo bata la kuyimitsidwa.
Mapulogalamu
M'makampani opanga mankhwala, HPC imagwiritsidwa ntchito kwambiri popanga mankhwala osiyanasiyana monga kuyimitsidwa pakamwa, jekeseni, ndi kukonzekera maso. Mwachitsanzo, pakuyimitsidwa kwapakamwa, HPC imatha kuwongolera kuyimitsidwa ndi kukhazikika kwa mankhwalawa, kuonetsetsa kuti mankhwalawa sakhazikika panthawi yosungira, potero kumapangitsa kuti mankhwalawa akhale othandiza komanso otetezeka. Mu jakisoni, HPC imatha kuonjezera bioavailability wa mankhwala ndi kupititsa patsogolo mphamvu zawo mwa solubilization.
M'makampani azakudya, HPC imagwiritsidwa ntchito kwambiri pazinthu zoyimitsidwa monga timadziti, mkaka ndi zokometsera. HPC imatha kupititsa patsogolo kukhuthala ndi kukhazikika kwa kuyimitsidwa, kuteteza kukhazikika ndi kukhazikika kwa tinthu tating'onoting'ono, ndikuwonetsetsa kufanana ndi kukoma kwa chinthucho.
Hydroxypropylcellulose imagwira ntchito yofunika kwambiri pakukulitsa kukhazikika kwa kuyimitsidwa. Kupyolera mu thickening, stabilizing ndi solubilizing katundu, HPC akhoza kwambiri kuonjezera mamasukidwe akayendedwe suspensions, kuchepetsa yokhazikika liwiro particles olimba, kupanga zoteteza guluu wosanjikiza kuteteza tinthu aggregation, ndi kuonjezera solubility wa zinthu bwino sungunuka. Izi zimapangitsa HPC kugwiritsidwa ntchito kwambiri pazamankhwala, chakudya ndi zodzoladzola, kukhala gawo lofunikira pakuwongolera kukhazikika kwa kuyimitsidwa.
Nthawi yotumiza: Jul-21-2024