HPMC (hydroxypropyl methylcellulose) imagwiritsidwa ntchito kawirikawiri mankhwala ogwiritsidwa ntchito popanga mitundu yosiyanasiyana ya mitundu ya mankhwala, kuphatikizapo mapiritsi, makapisozi, ndi mafoso, ndi ophshalmic. Chimodzi mwazinthu zofunikira za HPMC ndi mawonekedwe ake, omwe amakhudza katundu wa chinthu chomaliza. Nkhaniyi ilongosola ubale womwe ulipo pakati pa HPMC ndi kutentha ndikuwonetsa kusamala komwe kuyenera kumwedwa mukamagwiritsa ntchito izi.
Ubale pakati pa HPMC Utu ndi Kutentha
HPMC ndi polyrophilic polymer yomwe imasungunuka m'madzi ndi pomron. HPMC ikasungunuka m'madzi, imapanga yankho la viscous chifukwa cha kulemera kwamphamvu kwa polymer ndi kuchuluka kwa hydrophilicity. Kuzindikira kwa ma hpmc mayankho a HPMC kumakhudzidwa ndi zinthu zingapo, kuphatikizapo kuchuluka kwa polymer, kutentha kwa yankho, ndi pH ya zosungunulira.
Chimodzi mwazinthu zazikulu zomwe zimakhudza mafayilo a HPMC yankho. Makutu a HPMC mayankho a HPMC amachepetsa ndi kutentha kwambiri. Izi ndichifukwa choti kutentha kwambiri, maunyolo a polyme amakhala madzi ambiri, chifukwa cha magulu ochepera omwe amakhala ndi maunyolo ochepa. Zotsatira zake, mafayilo a yankho amachepetsa ndipo madzi a yankho limawonjezeka.
Chibwenzi Pakati pa kutentha ndi mavinyo a HPMC zitha kufotokozedwa ndi arrheenius equation. Insius equation ndi gawo la masamu lomwe limafotokoza ubale pakati pa kuchuluka kwa mankhwala ndi kutentha kwa dongosolo. Kwa HPMC mayankho, equation yowerengera imatha kugwiritsidwa ntchito pofotokoza ubale womwe ulipo pakati panu ndi kutentha kwa dongosolo.
Equius Equation imaperekedwa ndi:
K = AE ^ (- ea / rt)
Komwe K ndi kuchuluka kwake, ndiye chinthu chofunikira kwambiri, EA ndiye mphamvu yothandizira, r ndiye mpweya wokhazikika, ndipo T ndi kutentha kwa dongosololi. Makulidwe a ma hpmc mayankho a HPMC amakhudzana ndi kuchuluka kwa zosungunulira kudzera mu polymer matrix, omwe amawongoleredwa ndi mfundo yomweyo chifukwa kuchuluka kwa mankhwalawa. Chifukwa chake, equation equation imatha kugwiritsidwa ntchito pofotokoza ubale womwe ulipo pakati panu ndi kutentha kwa dongosolo.
Zinthu Zoyenera Kulemba Mukamagwiritsa Ntchito HPMC
Mukamagwira ntchito ndi hpmc, mosamala mosamala kuyenera kuthandizidwa kuti awonetsetse kuti polymer. Izi zimaphatikizapo:
1. Gwiritsani ntchito zida zoteteza
Ndikofunikira kugwiritsa ntchito zida zoteteza monga magolovu, magalasi, ndi zovala za labu mukamagwira hpmc. Izi zili choncho chifukwa HPMC imatha kukwiya khungu ndi maso, ndipo imatha kuyambitsa mavuto ngati mumizidwa. Chifukwa chake, ndikofunikira kuchitapo kanthu kuti muchepetse chiopsezo cha kuwonekera kwa polima.
2. Sungani HPMC molondola
HPMC iyenera kusungidwa pamalo ozizira, owuma kuti mupewe kuyamwa kwa chinyezi mlengalenga. Izi ndichifukwa choti HPMC ndi hygrascopic, kutanthauza kuti imatenga chinyezi kuchokera kumalo ake ozungulira. Ngati HPMC imatenga chinyezi chambiri, zimatha kukhudza ma viscction ndi zinthu za chinthu chomaliza.
3. Samalani ndi kuchuluka kwa kuchuluka ndi kutentha
Mukamapanga ndi HPMC, onetsetsani kuti mwatchera khutu ndi kutentha kwa yankho. Izi ndichifukwa chakuti mafayilo a mayankho a HPMC amadziwika kwambiri ndi zinthu izi. Ngati ndende kapena kutentha kumakhala kochepa kwambiri kapena kutsika kwambiri, kumakhudza mafayilo ndi katundu wa chinthu chomaliza.
4. Gwiritsani ntchito njira zoyenera
Mukakonza hpmc, ndikofunikira kugwiritsa ntchito njira zoyenera kukonza kukonza kuti muwonetsetse bwino polima polymer. Izi zingaphatikizepo kugwiritsa ntchito njira zosakanikirana zosakanikirana kuti muchepetse polymer kapena kusokonezeka, kapena kugwiritsa ntchito njira zoyenera zowuma kuchotsa chinyezi chomaliza pamalonda omaliza.
5. Onani Kuphatikizira
Mukamagwiritsa ntchito HPMC ngati yosangalatsa, ndikofunikira kuyang'ana kuphatikizidwa ndi zina ndi zosakaniza ndi zosakaniza zachangu pakupanga. Izi ndichifukwa choti HPMC imatha kulumikizana ndi zosakaniza zina popanga, zomwe zimakhudza magwiridwe antchito ndi kukhazikika kwa chinthu chomaliza. Chifukwa chake, ndikofunikira kuchititsa maphunziro ogwirizana kuti azindikire zovuta zomwe zingachitike musanachitike.
Pomaliza
Makutu a HPMC mayankho a HPMC imakhudzidwa ndi zinthu zingapo, kuphatikizapo chidwi, kutentha, ndi pH. Makutu a HPMC mayankho a HPMC amachepetsa ndi kutentha kwambiri chifukwa chochulukirachulukira kwa maunyolo a polymer. Mukamagwira ntchito ndi HPMC, ndikofunikira kuti muchepetse kusamalira bwino poyipizi. Izi zimaphatikizapo kugwiritsa ntchito zida zoteteza, kusunga bwino HPMC, kusamala ndi kukhazikika kwa kuchuluka ndi kutentha koyenera, ndikuyang'ana njira zina mu formula. Mwa kumwa mosamala kanthu, hpmc imatha kugwiritsidwa ntchito ngati yothandiza kwambiri m'mapanga osiyanasiyana a mankhwala.
Post Nthawi: Sep-25-2023