HPMC (Hydroxypropyl Methylcellulose) ndi polima zakuthupi ntchito kwambiri zokutira ndi mankhwala kukonzekera, ndi zabwino filimu kupanga, thickening, bata ndi adhesion. M'munda wa zokutira, HPMC imagwiritsidwa ntchito makamaka pamakina opangira madzi, omwe amatha kusintha kwambiri kumamatira kwa zokutira ndi ntchito yawo yonse.
1. Basic katundu wa HPMC
HPMC ndi yochokera ku cellulose yopanda ionic yokhala ndi mawonekedwe apadera akuthupi ndi mankhwala. Poyankha, HPMC imatha kupanga kuyanjana kwathupi ndi mankhwala ndi gawo lapansi kudzera mu unyolo wa maselo, potero kupanga filimu yokhala ndi mphamvu zamakina komanso kukhazikika. Kanemayu ali ndi kusinthasintha kwabwino komanso kukana kwa ming'alu, zomwe zingathandize ❖ kuyanika kuti agwirizane bwino ndi mawonekedwe a gawo lapansi, potero kumathandizira kumamatira.
Makina opangira filimu a HPMC amagwirizana kwambiri ndi kuphatikizika ndi kuphatikizika kwa maunyolo ake. Magulu a hydroxypropyl ndi methyl mu molekyulu ya HPMC amapanga kukhala hydrophilic ndi hydrophobic yankho. Amphiphilicity iyi imathandiza HPMC kudzisonkhanitsa yokha kukhala wandiweyani mu dongosolo lopaka madzi, potero kumapangitsa mphamvu zamakina ndi kumamatira kwa zokutira.
2. Zinthu zomwe zimakhudza mphamvu yomatira ya zokutira ndi HPMC
Kukhazikika kwa HPMC:
Kuchuluka kwa HPMC mu zokutira kumakhudza kwambiri mphamvu yomatira ya zokutira. Kuchulukirachulukira kwa HPMC kumawonjezera kukhuthala kwa zokutira ndikuwongolera mawonekedwe opangira filimu, potero kumapangitsa kumamatira kwa zokutira pamtunda. Komabe, kuchuluka kwambiri kwa HPMC kungayambitse makulidwe a ❖ kuyanika osagwirizana komanso kukhudza kumamatira. Kafukufuku wasonyeza kuti ndende yoyenera ya HPMC imatha kumangiriza zokutira pamwamba pa gawo lapansi, ndipo kutsika kwambiri kapena kutsika kwambiri kumakhala ndi zotsatira zoyipa pamamatira.
pH mtengo ndi kutentha kwa yankho:
Kusungunuka kwa HPMC ndi mawonekedwe ake opanga mafilimu amakhudzidwa ndi pH mtengo ndi kutentha. M'malo acidic kapena amchere, kusungunuka kwa mamolekyu a HPMC kumasintha, zomwe zimakhudzanso mphamvu yomatira ya zokutira. Nthawi zambiri, mikhalidwe ya pH yokhazikika imatha kusunga bata kwa HPMC ndikulimbikitsa kulumikizana kwake ndi gawo lapansi. Kuphatikiza apo, kutentha kumakhudzanso kuyenda ndi liwiro lopanga filimu la HPMC ma cell chain. Kutentha kwapamwamba nthawi zambiri kumatha kufulumizitsa kusinthasintha kwa njira yothetsera vutoli ndikulola kuti zokutira zipangidwe mofulumira, koma zingapangitse kukangana kwa mkati mwa filimuyo, potero kumakhudza mphamvu yomatira ya zokutira.
Kulemera kwa molekyulu ya HPMC:
The molekyulu kulemera kwa HPMC mwachindunji zimakhudza ake rheological katundu ndi filimu kupanga katundu ❖ kuyanika. HPMC ndi wokulirapo maselo kulemera akhoza kupanga wamphamvu filimu wosanjikiza, potero kuonjezera adhesion wa ❖ kuyanika, koma solubility ake ndi fluidity ndi osauka, amene mosavuta kuchititsa osauka ❖ kuyanika ❖ kuyanika ndi pamwamba akhakula. M'malo mwake, ngakhale HPMC ndi ang'onoang'ono maselo kulemera ndi bwino solubility ndi fluidity, mawotchi mphamvu pambuyo filimu mapangidwe otsika, ndi kusintha kwa adhesion mphamvu ❖ kuyanika ndi ochepa. Choncho, kusankha HPMC ndi oyenera maselo kulemera akhoza kugunda bwino pakati ❖ kuyanika ntchito ndi adhesion.
Kukhuthala kwa HPMC:
Monga thickener, HPMC akhoza kwambiri kuonjezera mamasukidwe akayendedwe a dongosolo ❖ kuyanika, potero kuwongolera fluidity ndi yunifolomu ❖ kuyanika. Mapangidwe a yunifolomu ndi wandiweyani wosanjikiza filimu pamwamba pa gawo lapansi ndiye chinsinsi chothandizira mphamvu zomatira, ndipo HPMC imatha kuletsa zokutira kuti zisagwe kapena kutulutsa zikwangwani pamwamba pa gawo lapansi posintha kukhuthala kwa zokutira, potero. kuonjezera ntchito yomatira ya zokutira.
3. Kugwiritsa ntchito HPMC m'malo osiyanasiyana
Metal substrates:
Pazitsulo zazitsulo, kumamatira kwa zokutira nthawi zambiri kumakhudzidwa ndi kusalala kwachitsulo pamwamba ndi oxide wosanjikiza. HPMC bwino filimu kupanga katundu ndi kusinthasintha kwa ❖ kuyanika, kupanga ❖ kuyanika kukhala bwino pamwamba zitsulo pamwamba, kuchepetsa mawonekedwe opunduka pakati ❖ kuyanika ndi zitsulo, potero kuwongolera adhesion wa ❖ kuyanika. Kuphatikiza apo, HPMC imathanso kugwira ntchito mogwirizana ndi ma tackifiers ena kuti ipititse patsogolo mphamvu zamakina zokutira.
Magawo apulasitiki:
Magawo apulasitiki nthawi zambiri amakhala ndi mphamvu zochepa, ndipo zimakhala zovuta kuti zokutira zigwirizane kwambiri ndi mawonekedwe awo. Chifukwa cha mawonekedwe ake apadera a maselo, HPMC imatha kupanga zomangira zolimba za haidrojeni pamwamba pa pulasitiki, potero kuwongolera kumamatira kwa zokutira. Nthawi yomweyo, monga thickener, HPMC akhoza kukhathamiritsa mulingo wa zokutira pamwamba pulasitiki ndi kupewa shrinkage kapena kusweka kwa zokutira.
Magawo a ceramic ndi magalasi:
Maonekedwe a zinthu zakuthupi monga zoumba ndi galasi ndizosalala kwambiri, ndipo zimakhala zovuta kuti zokutira zigwirizane bwino. HPMC imawongolera kunyowa ndi kumamatira kwa zokutira pamwamba pa magawowa pochita ngati chothandizira kupanga filimu mu zokutira. Kuphatikiza apo, luso lopanga filimu la HPMC limatha kupanga ming'alu yaying'ono yopangidwa ndi zokutira pamwamba pa gawo lapansi ndikuwonjezera kumamatira konse.
4. Zolepheretsa kugwiritsa ntchito ndi njira zowongolera za HPMC
Ngakhale HPMC ili ndi gawo lalikulu pakuwongolera kumamatira kwa zokutira, imakhalabe ndi zoletsa zina pakugwiritsa ntchito. Mwachitsanzo, HPMC ili ndi zotsatira zochepa pa kuwongolera kukhazikika kwa zokutira m'malo ovuta kwambiri, makamaka pansi pa chinyezi chambiri kapena kutentha kwambiri, komwe mawonekedwe ake opanga filimu amatha kuchepa ndipo zokutira zimatha kugwa. Chifukwa chake, ofufuza akufufuza njira zopititsira patsogolo magwiridwe antchito a HPMC kudzera mukusintha kwamankhwala kapena kuphatikiza ndi zinthu zina za polima. Mwachitsanzo, poyambitsa zolumikizira zolumikizirana kapena zomatira zamphamvu kwambiri, kukhazikika kwa HPMC pansi pazovuta kumatha kukulitsidwa.
Monga chowonjezera chokulirapo chofunikira, HPMC imatha kusintha kwambiri mphamvu yomatira ya zokutira. Mawonekedwe ake opanga mafilimu, kukhuthala, komanso kuyanjana kwathupi ndi mankhwala ndi gawo lapansi ndi zinthu zofunika kwambiri pakugwira ntchito kwake. Posintha moyenera kuchuluka kwa ma cell, kulemera kwa maselo, komanso chilengedwe cha HPMC, zotsatira zake pakuwongolera kumamatira kwa zokutira zimatha kukulitsidwa. M'tsogolomu, kusintha kwa magwiridwe antchito a HPMC kudzabweretsa mwayi wochulukirapo kumakampani opanga zokutira, makamaka pankhani ya zokutira zatsopano zoteteza chilengedwe.
Nthawi yotumiza: Oct-11-2024