HPMC ndi semi-synthetic polima yochokera ku cellulose. Chifukwa cha kukhuthala kwake, kukhazikika komanso kupanga mafilimu, amagwiritsidwa ntchito kwambiri muzamankhwala, chakudya, zodzoladzola ndi mafakitale ena. Kuphunzira kachitidwe ka mamasukidwe ake ndikofunikira kuti mukwaniritse ntchito zake zosiyanasiyana.
1. Muyezo wa viscosity:
Viscometer yozungulira: Viscometer yozungulira imayesa torque yofunikira kuti izungulire spindle pa liwiro lokhazikika ikamizidwa mu zitsanzo. Posintha ma geometry ndi liwiro lozungulira la spindle, kukhuthala kwa ma viscosity pamitundu yosiyanasiyana yakumeta ubweya kumatha kuzindikirika. Njira imeneyi chimathandiza makhalidwe a HPMC mamasukidwe akayendedwe mu zinthu zosiyanasiyana.
Capillary Viscometer: Kapilari viscometer imayesa kutuluka kwa madzi kudzera mu chubu cha capillary motengera mphamvu yokoka kapena kupanikizika. Yankho la HPMC limakakamizika kudzera mu chubu cha capillary ndipo mamasukidwe akayendedwe amawerengedwa potengera kuchuluka kwa kuthamanga ndi kutsika kwamphamvu. Njirayi ingagwiritsidwe ntchito pophunzira kukhuthala kwa HPMC pamitengo yotsika yometa ubweya.
2.Muyezo wa Rheological:
Dynamic Shear Rheometry (DSR): DSR imayesa kuyankhidwa kwa chinthu ku kusinthika kwamakameta amphamvu. Zitsanzo za HPMC zidakhala ndi kupsinjika kwa kumeta ubweya wa oscillatory ndipo zovuta zake zidayesedwa. Makhalidwe a viscoelastic a mayankho a HPMC amatha kudziwika ndi kusanthula makulidwe ovuta (η *) komanso modulus yosungirako (G') ndi loss modulus (G").
Mayesero oyenda ndi kuchira: Mayeserowa amaphatikizapo kuyika zitsanzo za HPMC kuti zikhale zovuta nthawi zonse kapena kupanikizika kwa nthawi yaitali (gawo la creep) ndikuwunika kuchira pambuyo pa kupsinjika maganizo kapena kupsinjika maganizo. Kuyenda ndi kuchira kumapereka chidziwitso pamayendedwe a viscoelastic a HPMC, kuphatikiza kusinthika kwake ndikuchira.
3. Maphunziro odalira kwambiri komanso kutentha:
Concentration Scan: Miyezo ya viscosity imachitika pamitundu ingapo ya HPMC kuti iphunzire ubale pakati pa mamasukidwe akayendedwe ndi ndende ya polima. Izi zimathandiza kumvetsetsa kukhuthala kwa polima ndi machitidwe ake odalira kwambiri.
Kujambula kwa kutentha: Miyezo ya viscosity imachitika pa kutentha kosiyana kuti iphunzire momwe kutentha kumayendera pa HPMC viscosity. Kumvetsetsa kudalira kwa kutentha ndikofunikira pamapulogalamu omwe ma HPMC amakumana ndi kusintha kwa kutentha, monga kupanga mankhwala.
4. Kusanthula kulemera kwa maselo:
Kupatula Kukula Chromatography (SEC): SEC imalekanitsa mamolekyu a polima kutengera kukula kwawo mu yankho. Powunika mbiri ya elution, kugawa kwa maselo amtundu wa HPMC kumatha kuzindikirika. Kumvetsetsa mgwirizano pakati pa kulemera kwa maselo ndi viscosity ndikofunikira kuti tilosere machitidwe a rheological a HPMC.
5. Kutengera ndi Kuyerekeza:
Zitsanzo zamalingaliro: Zitsanzo zosiyanasiyana zamalingaliro, monga Carreau-Yasuda model, Cross model kapena power law model, zitha kugwiritsidwa ntchito pofotokoza kakhalidwe ka mamasukidwe akayendedwe a HPMC pansi pamikhalidwe yometa ubweya wosiyanasiyana. Zitsanzozi zimaphatikiza magawo monga shear rate, ndende, ndi kulemera kwa maselo kuti adziwike molondola kukhuthala.
Computational Simulations: Computational Fluid Dynamics (CFD) zoyerekeza zimapereka chidziwitso pamayendedwe amayendedwe a HPMC mu ma geometries ovuta. Pothetsa ma equation olamulira akuyenda kwamadzimadzi, zofananira za CFD zimatha kulosera kugawa kwa mamasukidwe ndi mayendedwe osiyanasiyana.
6. Maphunziro a in situ ndi in vitro:
Miyezo ya in-situ: Njira za in-situ zimaphatikizapo kuphunzira kusintha kwa viscosity munthawi yeniyeni pamalo enaake kapena kugwiritsa ntchito. Mwachitsanzo, pamapangidwe amankhwala, miyeso ya in situ imatha kuyang'anira kusintha kwa kukhuthala kwa piritsi pakusweka kwa piritsi kapena kugwiritsa ntchito gel osakaniza.
Kuyesa kwa in vitro: Kuyesa kwa in vitro kumatengera momwe thupi limakhalira kuti liwunikire momwe ma viscosity amapangidwira amtundu wa HPMC omwe amapangidwira pakamwa, pakamwa, kapena pamutu. Mayeserowa amapereka chidziwitso chofunikira pa momwe zimagwirira ntchito komanso kukhazikika kwa mapangidwewo pansi pamikhalidwe yoyenera yachilengedwe.
7.ukadaulo wapamwamba:
Microrheology: Njira za Microrheology, monga dynamic light scattering (DLS) kapena particle tracking microrheology (PTM), zimalola kufufuza mawonekedwe a viscoelastic amadzimadzi ovuta pamlingo wa microscopic. Njirazi zitha kupereka zidziwitso zamakhalidwe a HPMC pamlingo wa mamolekyulu, zomwe zimakwaniritsa miyeso ya macroscopic rheological.
Nuclear Magnetic Resonance (NMR) Spectroscopy: NMR spectroscopy ingagwiritsidwe ntchito pophunzira mphamvu ya maselo ndi kuyanjana kwa HPMC mu yankho. Poyang'anira kusintha kwa mankhwala ndi nthawi yopumula, NMR imapereka chidziwitso chofunikira pa kusintha kwa HPMC ndi kuyanjana kwa polima-zosungunulira zomwe zimakhudza kukhuthala.
Kuphunzira kakhalidwe ka mamasukidwe akayendedwe a HPMC kumafuna njira zosiyanasiyana, kuphatikiza njira zoyesera, mafanizo amalingaliro, ndi njira zowunikira zapamwamba. Pogwiritsa ntchito kuphatikiza kwa viscometry, rheometry, kusanthula kwa maselo, zitsanzo, ndi njira zamakono, ochita kafukufuku amatha kumvetsa bwino za rheological properties za HPMC ndikuwonjezera ntchito yake mu ntchito zosiyanasiyana.
Nthawi yotumiza: Feb-29-2024