Zothandizira Zamankhwala Ma cellulose Ether

Natural cellulose ether ndi mawu wamba pa mndandanda wazotumphukira za celluloseopangidwa ndi zimene alkali mapadi ndi etherifying wothandizira pa zinthu zina. Ndi mankhwala omwe magulu a hydroxyl pa cellulose macromolecules amasinthidwa pang'ono kapena kwathunthu ndi magulu a ether. Ma cellulose ethers amagwiritsidwa ntchito kwambiri pantchito zamafuta, zomangira, zokutira, chakudya, mankhwala, ndi mankhwala atsiku ndi tsiku. M'madera osiyanasiyana, mankhwala opangidwa ndi mankhwala ali makamaka pakati komanso apamwamba kwambiri pamakampani, ndi mtengo wowonjezera. Chifukwa chofunika kwambiri khalidwe, kupanga mankhwala-kalasi mapadi ether ndi kovuta. Tinganene kuti khalidwe la mankhwala-kalasi mankhwala akhoza kwenikweni kuimira luso luso mabizinesi mapadi ether. Ma cellulose ether nthawi zambiri amawonjezedwa ngati chotchinga, matrix ndi thickener kuti apange mapiritsi a matrix okhazikika, zinthu zokutira zosungunuka zam'mimba, zida zokutira za microcapsule zosasunthika, zida zamakanema zama mankhwala osokoneza bongo, ndi zina zambiri.

Sodium carboxymethyl cellulose:

Carboxymethyl cellulose sodium (CMC-Na) ndiye mtundu wa ether wa cellulose womwe umapangidwa ndikumwa kwambiri kunyumba ndi kunja. Ndi ionic cellulose ether yopangidwa kuchokera ku thonje ndi matabwa kudzera mu alkalization ndi etherification ndi chloroacetic acid. CMC-Na ndi mankhwala omwe amagwiritsidwa ntchito kwambiri. Nthawi zambiri amagwiritsidwa ntchito ngati chomangira pokonzekera zolimba, zowonjezera zowonjezera, zowonjezera, ndi zoyimitsa zokonzekera zamadzimadzi. Itha kugwiritsidwanso ntchito ngati matrix osungunuka m'madzi komanso kupanga filimu. Nthawi zambiri amagwiritsidwa ntchito ngati filimu yamankhwala yosalekeza komanso piritsi la matrix lomasulidwa mosalekeza pokonzekera zotulutsidwa (zoyendetsedwa).

Kuphatikiza pa sodium carboxymethylcellulose monga chothandizira pamankhwala, croscarmellose sodium itha kugwiritsidwanso ntchito ngati chothandizira mankhwala. Croscarmellose sodium (CCMC-Na) ndi chinthu chosasungunuka m'madzi cha carboxymethylcellulose chomwe chimachita ndi cholumikizira pa kutentha kwina (40-80 ° C) mothandizidwa ndi chothandizira cha inorganic acid ndikuyeretsedwa. Monga crosslinking wothandizira, propylene glycol, succinic anhydride, maleic anhydride ndi adipic anhydride angagwiritsidwe ntchito. Croscarmellose sodium amagwiritsidwa ntchito ngati disintegrant pamapiritsi, makapisozi ndi ma granules pokonzekera pakamwa. Zimadalira pa capillary ndi kutupa zotsatira kuti ziwonongeke. Ili ndi compressibility yabwino komanso mphamvu yophatikizika kwambiri. Kafukufuku wawonetsa kuti kuchuluka kwa kutupa kwa croscarmellose sodium m'madzi ndikwambiri kuposa zomwe zimaphatikizidwira m'malo monga carmellose sodium ndi hydrated microcrystalline cellulose.

Methylcellulose:

Methyl cellulose (MC) ndi cellulose yopanda ionic ether yopangidwa kuchokera ku thonje ndi matabwa kudzera mu alkalization ndi methyl chloride etherification. Methylcellulose ali ndi madzi osungunuka bwino ndipo ndi okhazikika pa pH2.0 ~ 13.0. Amagwiritsidwa ntchito kwambiri pamankhwala othandizira mankhwala, ndipo amagwiritsidwa ntchito m'mapiritsi a sublingual, jekeseni wa intramuscular, ophthalmic kukonzekera, makapisozi a m'kamwa, kuyimitsidwa kwapakamwa, mapiritsi am'kamwa ndi mankhwala apakhungu. Kuphatikiza apo, pokonzekera kumasulidwa kosalekeza, MC ikhoza kugwiritsidwa ntchito ngati kukonzekera kwa hydrophilic gel matrix, zinthu zokutira zosungunuka zam'mimba, zida zokutira za microcapsule zosasunthika, zida zamakanema zamankhwala zotulutsidwa, ndi zina zambiri.

Hydroxypropyl methyl cellulose:

Hydroxypropyl methylcellulose (HPMC) ndi cellulose yopanda ionic yosakanikirana ndi ether yopangidwa kuchokera ku thonje ndi nkhuni kudzera mu alkalization, propylene oxide ndi methyl chloride etherification. Ndiwopanda fungo, wosakoma, wosakhala ndi poizoni, wosungunuka m'madzi ozizira ndi gelled m'madzi otentha. Hydroxypropyl methylcellulose ndi mtundu wa ether wosakanizidwa wa cellulose womwe kupanga kwake, mlingo wake ndi mtundu wake zakhala zikuchulukirachulukira ku China pazaka 15 zapitazi. Ndi imodzi mwazinthu zomwe zimagwiritsidwa ntchito kwambiri popanga mankhwala kunyumba ndi kunja. zaka za mbiriyakale. Pakadali pano, kugwiritsa ntchito kwa HPMC kumawonekera kwambiri pazinthu zisanu izi:

Mmodzi ali ngati womangira ndi disntegrant. Monga chomangira, HPMC imatha kupangitsa kuti mankhwalawa akhale osavuta kunyowa, ndipo amatha kukulitsa nthawi mazanamazana atamwa madzi, kotero amatha kusintha kwambiri kuchuluka kwa kusungunuka kapena kutulutsa kwa piritsi. HPMC ili ndi mamasukidwe amphamvu, omwe amatha kupititsa patsogolo kukhuthala kwa tinthu ndikuwongolera kukhazikika kwazinthu zopangira ndi khirisipi kapena Chimaona. HPMC ndi otsika mamasukidwe akayendedwe angagwiritsidwe ntchito ngati binder ndi disintegrant, ndi amene ali ndi mamasukidwe akayendedwe mkulu angagwiritsidwe ntchito ngati binder.

Chachiwiri ndi chokhazikika komanso chowongolera chomasulidwa pokonzekera pakamwa. HPMC ndi zinthu zomwe zimagwiritsidwa ntchito kwambiri ndi hydrogel matrix pokonzekera kumasulidwa kosalekeza. Otsika mamasukidwe akayendedwe giredi (5-50mPa · s) HPMC angagwiritsidwe ntchito ngati binder, viscosifier ndi suspending wothandizira, ndi mkulu-kukhuthala kalasi kalasi (4000-100000mPa · s) HPMC angagwiritsidwe ntchito pokonza zinthu zosakaniza Kutsekereza wothandizila makapisozi, hydrogel masanjidwewo. mapiritsi otulutsidwa nthawi yayitali. HPMC imasungunuka m'madzi am'mimba, imakhala ndi ubwino wa compressibility wabwino, fluidity yabwino, mphamvu yotsegula mankhwala, ndi makhalidwe otulutsa mankhwala osakhudzidwa ndi PH. Ndi chinthu chofunikira kwambiri chonyamula ma hydrophilic pamakina okonzekera kumasulidwa ndipo nthawi zambiri amagwiritsidwa ntchito ngati Hydrophilic gel matrix ndi zokutira pokonzekera kumasulidwa kosalekeza, komanso zida zothandizira pokonzekera zoyandama zam'mimba komanso kukonzekera filimu yamankhwala osatha.

Chachitatu ndi chophikira chopangira mafilimu. HPMC ili ndi zinthu zabwino zopangira mafilimu. Filimu yopangidwa ndi iyo ndi yofanana, yowonekera komanso yolimba, ndipo sikophweka kumamatira panthawi yopanga. Makamaka mankhwala omwe ndi osavuta kuyamwa chinyezi komanso osakhazikika, kugwiritsa ntchito ngati kusanjikiza kwapadera kumatha kusintha kwambiri kukhazikika kwa mankhwalawa ndikuletsa Filimuyo imasintha mtundu. HPMC ali zosiyanasiyana kukhuthala makulidwe. Ngati asankhidwa bwino, ubwino ndi maonekedwe a mapiritsi ophimbidwa ndi apamwamba kuposa zipangizo zina. Nthawi zonse ndende ndi 2% mpaka 10%.

Chachinayi ndi ngati kapisozi zakuthupi. M'zaka zaposachedwa, kufalikira kwa miliri yapadziko lonse ya nyama, poyerekeza ndi makapisozi a gelatin, makapisozi amasamba akhala okonda kwambiri m'makampani opanga mankhwala ndi zakudya. Pfizer wa ku United States watulutsa bwino HPMC ku zomera zachilengedwe ndikukonzekera makapisozi a masamba a VcapTM. Poyerekeza ndi makapisozi amtundu wa gelatin, makapisozi a zomera ali ndi ubwino wosinthasintha, palibe chiopsezo chogwirizanitsa ndi kukhazikika kwakukulu. Mlingo wotulutsa mankhwalawa ndi wokhazikika, ndipo kusiyana kwapayekha kumakhala kochepa. Pambuyo pa kupasuka m'thupi la munthu, sichimatengedwa ndipo chikhoza kuchotsedwa Chinthucho chimachotsedwa m'thupi. Pankhani ya malo osungira, pambuyo pa mayesero ambiri, imakhala yosasunthika pansi pa chinyezi chochepa, ndipo katundu wa chipolopolo cha capsule akadali okhazikika pansi pa chinyezi chambiri, ndipo zizindikiro za makapisozi a zomera sizimakhudzidwa ndi kusungidwa kwakukulu. mikhalidwe. Ndi kumvetsetsa kwa anthu za makapisozi a zomera ndi kusintha kwa malingaliro amankhwala a anthu kunyumba ndi kunja, kufunikira kwa msika wa makapisozi a zomera kudzakula mofulumira.

Wachisanu ndi woyimitsa. Kuyimitsidwa-mtundu wamadzimadzi kukonzekera ndi njira yomwe imagwiritsidwa ntchito kwambiri pazachipatala, yomwe ndi njira yosiyana kwambiri yobalalika yomwe mankhwala osasungunuka olimba amamwazikana munjira yobalalika yamadzi. Kukhazikika kwa dongosolo kumatsimikizira ubwino wa kuyimitsidwa kwamadzimadzi kukonzekera. HPMC colloidal njira akhoza kuchepetsa olimba-zamadzimadzi interfacial mavuto, kuchepetsa padziko ufulu mphamvu ya particles olimba, ndi kukhazikika ndi sakanikira kubalalitsidwa dongosolo. Ndi njira yabwino kwambiri yoyimitsira. HPMC imagwiritsidwa ntchito ngati thickener kwa madontho a maso, okhala ndi 0.45% mpaka 1.0%.

Ma cellulose a Hydroxypropyl:

Hydroxypropyl cellulose (HPC) ndi cellulose yopanda ionic ether yopangidwa kuchokera ku thonje ndi matabwa kudzera mu alkalization ndi propylene oxide etherification. HPC nthawi zambiri imasungunuka m'madzi pansi pa 40 ° C ndi zosungunulira zambiri za polar, ndipo ntchito yake imagwirizana ndi zomwe zili mu gulu la hydroxypropyl ndi digiri ya polymerization. HPC imatha kukhala yogwirizana ndi mankhwala osiyanasiyana ndipo imakhala ndi inertia yabwino.

Low-substituted hydroxypropyl cellulose (L-HPC) amagwiritsidwa ntchito makamaka ngati disintegrant piritsi ndi binder. -HPC imatha kukulitsa kuuma ndi kuwala kwa piritsi, komanso kupangitsa kuti piritsilo liwonongeke mwachangu, limapangitsa kuti mkati mwa piritsi likhale labwino, komanso kuchiritsa bwino.

Highly substituted hydroxypropyl cellulose (H-HPC) itha kugwiritsidwa ntchito ngati chomangira mapiritsi, ma granules, ndi ma granules abwino m'munda wamankhwala. H-HPC ili ndi zinthu zabwino kwambiri zopanga filimu, ndipo filimu yomwe yapezedwa imakhala yolimba komanso yotanuka, yomwe ingafanane ndi mapulasitiki. Mawonekedwe a filimuyo amatha kupitilizidwa bwino pophatikizana ndi zinthu zina zotchingira chinyezi, ndipo nthawi zambiri amagwiritsidwa ntchito ngati filimu yopangira mapiritsi. H-HPC itha kugwiritsidwanso ntchito ngati matrix pokonzekera mapiritsi otulutsa matrix, ma pellets otulutsa mosalekeza ndi mapiritsi otulutsa osanjikiza kawiri.

Hydroxyethyl cellulose

Hydroxyethyl cellulose (HEC) ndi cellulose yopanda ionic ether yopangidwa kuchokera ku thonje ndi nkhuni kudzera mu alkalization ndi etherification wa ethylene oxide. M'munda wamankhwala, HEC imagwiritsidwa ntchito makamaka ngati thickener, colloidal zoteteza wothandizila, zomatira, dispersant, stabilizer, suspending wothandizira, filimu kupanga wothandizila ndi zisathe-kumasulidwa zakuthupi, ndipo angagwiritsidwe ntchito topical emulsions, mafuta odzola, madontho a maso, Madzi amkamwa, piritsi lolimba, kapisozi ndi mitundu ina ya mlingo. Ma cellulose a Hydroxyethyl adalembedwa mu US Pharmacopoeia/US National Formulary ndi European Pharmacopoeia.

Ethyl cellulose:

Ethyl cellulose (EC) ndi imodzi mwazinthu zomwe zimagwiritsidwa ntchito kwambiri m'madzi opanda cellulose. EC ndi yopanda poizoni, yokhazikika, yosasungunuka m'madzi, asidi kapena alkali solution, ndipo imasungunuka mu zosungunulira za organic monga ethanol ndi methanol. Nthawi zambiri zosungunulira ntchito ndi toluene/ethanol monga 4/1 (kulemera) wosanganiza zosungunulira. EC imagwiritsa ntchito kangapo pokonzekera kumasulidwa kosalekeza, komwe amagwiritsidwa ntchito kwambiri ngati zonyamulira, ma microcapsules, ndi zokutira zopangira mafilimu pokonzekera kumasulidwa kosalekeza, monga zotsekera mapiritsi, zomatira, ndi zida zokutira zamafilimu, zomwe zimagwiritsidwa ntchito ngati filimu yakuthupi yamatrix kukonzekera. mitundu yosiyanasiyana ya mapiritsi otulutsa matrix, omwe amagwiritsidwa ntchito ngati zinthu zosakanikirana pokonzekera zokonzekera zotulutsidwa, zotulutsa zokhazikika, ndikugwiritsidwa ntchito ngati zida zothandizira zopangira ma microcapsules omasulidwa; itha kugwiritsidwanso ntchito ngati chonyamulira zinthu Pokonzekera zolimba dispersions; amagwiritsidwa ntchito kwambiri muukadaulo wamankhwala ngati chinthu chopanga filimu ndi zokutira zoteteza, komanso zomangira ndi zodzaza. Monga chophimba chotetezera cha piritsi, chikhoza kuchepetsa kukhudzidwa kwa piritsi ku chinyezi ndikuletsa mankhwalawa kuti asakhudzidwe ndi chinyezi, kusinthika ndi kuwonongeka; ingathenso kupanga gel osanjikiza pang'onopang'ono, microencapsulate polima, ndikuthandizira kumasulidwa kosalekeza kwa zotsatira za mankhwala.