Hydroxypropyl methylcellulose (HPMC) ndi polima wosunthika wogwiritsidwa ntchito m'mafakitale osiyanasiyana chifukwa cha mawonekedwe ake apadera. Ngakhale angagwiritsidwe ntchito kupanga ma hydrogel pansi pazifukwa zina, sikuti ndi hydrogel yokha.
1. Chiyambi cha HPMC:
Hydroxypropyl methylcellulose (HPMC) ndi polima wa semi-synthetic wotengedwa ku cellulose, polima wachilengedwe wopezeka m'makoma a cell ya zomera. Amapangidwa pochiza cellulose ndi alkali kenako ndikuchitapo kanthu ndi propylene oxide ndi methyl chloride. Polima wotsatira amawonetsa zinthu zingapo zomwe zimapangitsa kuti zikhale zofunikira m'mafakitale osiyanasiyana, kuphatikiza mankhwala, chakudya, zodzoladzola, ndi zomangamanga.
2. Katundu wa HPMC:
HPMC ili ndi zinthu zingapo zothandiza:
a. Kusungunuka kwamadzi:
HPMC ndi sungunuka m'madzi, kupanga njira viscous. Katunduyu ndiwothandiza kwambiri pazamankhwala, komwe angagwiritsidwe ntchito popanga kuyimitsidwa, ma emulsions, komanso kupanga mankhwala owongolera.
b. Luso Lopanga Mafilimu:
HPMC imatha kupanga makanema osinthika komanso owoneka bwino akataya mayankho ake amadzi. Mafilimuwa amapeza ntchito mu zokutira zamapiritsi, makapisozi, ndi mafilimu apakamwa.
c. Kusintha kwa Rheology:
HPMC imagwira ntchito ngati thickener ndi rheology modifier mu njira zamadzimadzi. Kukhuthala kwake kumatha kusinthidwa ndikusintha zinthu monga kulemera kwa maselo ndi kuchuluka kwa m'malo.
d. Biocompatibility:
HPMC ndi biocompatible ndi si poizoni, kupanga kukhala oyenera ntchito mankhwala, zodzoladzola, ndi zakudya zakudya.
3. Ntchito za HPMC:
HPMC imapeza ntchito zofala m'mafakitale osiyanasiyana:
a. Zamankhwala:
M'mapangidwe amankhwala, HPMC imagwiritsidwa ntchito ngati chomangira, chosungunula, chopaka filimu, komanso matrix omasulidwa okhazikika. Imakulitsa kukhulupirika kwa piritsi, imayang'anira kutulutsa kwamankhwala kwamankhwala, komanso kumathandizira kutsata kwa odwala.
b. Makampani a Chakudya:
M'makampani azakudya, HPMC imagwiritsidwa ntchito ngati thickener, emulsifier, stabilizer, ndi gelling agent. Zimathandizira kuti zakudyazo zikhale zokhazikika, zowoneka bwino komanso zokhazikika, monga sosi, mavalidwe, ndi zokometsera.
c. Zodzoladzola:
HPMC amagwiritsidwa ntchito mu zodzoladzola ndi mankhwala chisamaliro munthu monga thickener, suspending wothandizira, filimu wakale, ndi emulsifier. Imapatsa zokometsera zokometsera zokometsera, mafuta odzola, ndi ma gels pomwe zimathandizira kukhazikika kwawo komanso kukhudzidwa kwawo.
d. Zomanga:
M'makampani omanga, HPMC imagwiritsidwa ntchito pazida za simenti ngati chosungira madzi, chowonjezera ntchito, komanso chowonjezera. Imawongolera mawonekedwe amatope ndi pulasitala, monga kumamatira, kulumikizana, komanso kukana kwa sag.
4. Hydrogel Mapangidwe ndi HPMC:
Ngakhale HPMC payokha si hydrogel, imatha kutenga nawo gawo pakupanga kwa hydrogel pansi pamikhalidwe yoyenera. Hydrogel ndi gulu la maunyolo a polima omwe amatha kuyamwa ndikusunga madzi ambiri. Mapangidwe a HPMC ma hydrogels nthawi zambiri amaphatikizira kulumikiza maunyolo a polima kuti apange maukonde amitundu itatu omwe amatha kuyamwa madzi.
a. Crosslinking Agents:
Ma crosslinking agents monga glutaraldehyde, genipin, kapena njira zakuthupi monga kuzizira kwa thaw atha kugwiritsidwa ntchito kuphatikizira maunyolo a HPMC. Kuphatikizikaku kumapangitsa kuti pakhale netiweki ya hydrogel mkati mwa matrix a HPMC.
b. Khalidwe Lotupa:
The katundu hydrogel wa HPMC akhoza ogwirizana ndi kusintha zinthu monga mlingo wa m'malo, maselo kulemera, ndi crosslinking kachulukidwe. Madigiri apamwamba olowa m'malo ndi zolemetsa zamamolekyu nthawi zambiri zimabweretsa kuchuluka kwa kutupa kwa hydrogel.
c. Kugwiritsa ntchito HPMC Hydrogels:
Ma HPMC hydrogel amapeza ntchito popereka mankhwala, kuchiritsa mabala, uinjiniya wa minofu, ndi magalasi olumikizirana. Ma biocompatibility awo, zinthu zosinthika, komanso kuthekera kosunga madzi zimawapangitsa kukhala oyenera kugwiritsa ntchito zamankhwala osiyanasiyana.
HPMC ndi polima yosunthika yokhala ndi ntchito zosiyanasiyana pazamankhwala, chakudya, zodzoladzola, ndi zomanga. Ngakhale kuti si hydrogel mwachilengedwe, imatha kutenga nawo gawo pakupanga kwa hydrogel polumikizana ndi maunyolo ake a polima. Zotsatira za HPMC hydrogels zimawonetsa zinthu monga kuyamwa madzi ndi kusungidwa, kuwapangitsa kukhala ofunikira pakugwiritsa ntchito zamankhwala. Pamene kafukufuku akupitilira kufufuza kagwiritsidwe ntchito kake ka HPMC, kufunikira kwake m'mafakitale osiyanasiyana akuyembekezeka kukulirakulira.
Nthawi yotumiza: Mar-06-2024